44,776 papers found

OBJECTIVE: To evaluate the degree to which conservative care and failure were specifically defined in studies comparing nonoperative treatment versus surgery for low back pain (LBP) conditions in adults. DATA SOURCES: A comprehensive literature search was conducted by an experienced librarian using MEDLINE (PubMed), E…

CONTEXT: Known polymorphisms of DNA repair genes can be associated with the risk of many types of cancer. There is no consensus regarding association between XRCC1 and OGG1 with breast cancer (BC). OBJECTIVES: The aim of this study is to collect relevant published studies systematically. DATA SOURCES: Sixty-two publi…

BACKGROUND: Accumulated studies have revealed that vascular endothelial growth factor (VEGF) plays an essential role in the progression of glioma, but the prognostic significance of VEGF expression for patients with glioma remains unknown. METHOD AND MATERIAL: A literature search of public databases (PubMed, ISI Web o…

BACKGROUND: CHDs form a complex and heterogeneous group of clinical entities, with high morbidity and mortality. With the advancement of surgical and invasive techniques and clinical treatment, the survival of these patients has increased significantly, and there are reports of a high prevalence of ocular abnormalities…

INTRODUCTION: Hyaluronic acid has come to represent the most widely used injectable cosmetic product in the world. Brought into being by the Swedish company Q-Med, in 2007 Macrolane™ was authorized for use in France, and the year after, it received official European approval as a means of breast augmentation. Si…

BACKGROUND: Malignant Pleural Effusion (MPE) is common with advanced malignancy. Palliative care with minimal adverse events is the cornerstone of management. Although talc pleurodesis plays an important role in treatment, the best modality of talc application remains controversial.   OBJECTIVE: To compare rates…

PURPOSE: Targeted therapies are currently the standard of care for metastatic renal cell carcinoma (mRCC). Five VEGF pathway inhibitors (sorafenib, sunitinib, bevacizumab in combination with interferon-alpha, pazopanib, and axitinib) and two mTOR inhibitors (everolimus and temsirolimus) are now FDA approved for mRCC ba…

BACKGROUND: Operative techniques commonly used for fissure in ano include: anal stretch, open lateral sphincterotomy, closed lateral sphincterotomy, posterior midline sphincterotomy and to a lesser extent dermal flap coverage of the fissure. Reports of direct comparisons between operative techniques for anal fissure ar…

BACKGROUND: Laser treatment may serve as an alternative or adjunctive treatment to conventional mechanical therapy in periodontics. The neodymium-doped:yttrium, aluminum, and garnet (Nd:YAG) laser has been used in periodontics. Systematic reviews aid in clinical decision-making. The aim of this study was to evaluate, i…

In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides data retrieval systems and computational resources for the analysis of data in GenBank and other biological data made available through NCBI's website. NCBI resources include Entrez,…

OBJECTIVES: Prescribing errors frequently threaten patient safety, with early career doctors writing most prescriptions. Prescribing feedback interventions can improve the prescribing capabilities of early career doctors. These typically involve interactions between people and materials; however, these relations tend t…

: Concern that COVID-19 vaccination causes pulmonary nodules persists because vaccination coincided with expanded computed tomography (CT), low-dose CT (LDCT) screening, post-COVID imaging and artificial intelligence (AI)-assisted detection. This review asks whether the current literature supports causality and how vac…

OBJECTIVE: To evaluate the environmental impact and sustainability-related practices of clear aligner therapy (CAT), focusing on environmental impact, economic implications, waste management, recycling practices, manufacturing processes, and aligner materials. It further explores the alignment of clear aligner practice…

PURPOSE: To characterize the etiologic distribution of uveitis in the United States through a systematic review and meta-analysis. METHODS: A systematic search of PubMed, Scopus, PubMed Central, and Web of Science identified U.S.-based cohort and cross-sectional studies reporting uveitis etiology. Random-effects meta-…

: Ageing populations face complex challenges, yet many older adults maintain well-being despite adversity. Understanding resilience offers critical direction for health promotion. This integrative review takes a conceptual and methodological approach to resilience in older adults, with clear implications for geriatric…

BACKGROUND: Chronic non-communicable diseases (NCDs) are a major public health challenge, representing the leading cause of disability and premature mortality worldwide. Beyond direct medical expenses, NCDs generate substantial indirect costs through productivity losses and reduced workforce participation. This study a…

BACKGROUND: Incisional hernia after stoma reversal is a frequent complication, yet the optimal method for fascial closure remains uncertain. This network meta-analysis (NMA) synthesized randomized evidence comparing closure techniques and prophylactic mesh reinforcement. METHODS: A systematic search of MEDLINE (PubMed…

INTRODUCTION: Yoga training has been shown to reduce health risks associated with a sedentary lifestyle. This meta-analytical approach systematically assesses the impact of Hatha yoga on non-communicable diseases (NCDs) and cardiometabolic disorders linked to sedentary lifestyles, including type II diabetes, hypertensi…

BACKGROUND: Supply chain management (SCM) is a central function of operational strategy and provides assurance of continuous delivery of services and products across different industries. While Artificial Intelligence (AI) has transformed SCM in other industries through predictive analytics, its application within heal…

Leptospirosis, a neglected zoonotic disease caused by pathogenic Leptospira spp., poses ongoing challenges in China due to shared environmental exposure of humans and dogs. To summarize available epidemiological evidence, we conducted a PRISMA-compliant systematic review and meta-analysis of human and canine leptospiro…