382,842 papers found

Researchers often seek to synthesize results of multiple studies on the same topic to draw statistical or substantive conclusions and to estimate effect sizes that will inform power analyses for future research. The most popular synthesis approach is meta-analysis. There have been few discussions and applications of ot…

The hierarchical metaregression (HMR) approach is a multiparameter Bayesian approach for meta-analysis, which generalizes the standard mixed effects models by explicitly modeling the data collection process in the meta-analysis. The HMR allows to investigate the potential external validity of experimental results as we…

We undertook a systematic review (incorporating meta-analysis) of the literature concerning the neurotoxicity of cumulative low level occupational exposure to organophosphate pesticides, which was published online by the journal Critical Reviews in Toxicology in 2012. As far as we are aware, we were the first research…

Estimators for the variance between treatment effects from randomized clinical trials (RCTs) in a meta-analysis may yield divergent or even contradictory results. In a sequential meta-analysis (SMA), their properties are even more important, as they influence the point in time at which definite conclusions are drawn. I…

Systematic reviews have become a key strategy to identifying evidence-based practice guidelines in infection prevention. They are considered the highest level of evidence providing the most effective answers to practice questions. Infection preventionists need to become familiar with reading systematic reviews and lear…

Participating in a scholarly activity is one of the training requirements for cardiology fellows. However, it can be very challenging to complete a research project during such a busy period of clinical training. To help the cardiology fellows in choosing and starting off a research project, a light has been shed on th…

Endometrial scratching or injury was first suggested a decade ago as a simple intervention to improve endometrial receptivity in patients undergoing ART. More than a decade later, based on weak evidence some doctors have adopted this strategy, although there is not yet agreement about its real benefit. In this opinion…

As in other disciplines in medicine, systematic reviews (SR) and meta-analyses (MA) in infectious diseases are an important aid to clinical decision-making. In the present article we review features important to SRs in infectious diseases that should be addressed in most SRs and MAs. We stress the need to include in th…

Peñaherrera-Carrillo et al. recently presented a systematic review and meta-analysis in the Journal of Robotic Surgery (2026) reporting a pooled periprosthetic fracture incidence of 0.11% following tracker pin placement in 13,217 robotic- and navigation-assisted TKA procedures. Although the article highlights an i…

INTRODUCTION: With the rapid ageing of the global population, the number of persons with dementia (PwDs) is increasing, placing substantial psychological and physical burdens on family caregivers. Acceptance and commitment therapy (ACT), a mindfulness and values-based psychological intervention, has shown potential in…

BACKGROUND: With the exponential growth of public RNA-seq datasets, meta-analysis has become a crucial tool for integrating studies to increase statistical power and identify consistent biological patterns. However, conventional p value combination methods were not designed for large-scale integration and exhibit a cri…

Accurate assessment of adverse event (AE) incidence is critical in clinical research for drug safety. While meta-analysis serves as an essential tool to comprehensively synthesize the evidence across multiple studies, incomplete AE reporting in clinical trials remains a persistent challenge. In particular, AEs occurrin…

BACKGROUND: In a meta-analysis where the effect size varies substantially between studies it is important to report the extent of the variation. Critically, we want to know if the treatment is always helpful or sometimes harmful. The statistic that addresses this is the prediction interval (PI), which gives the range o…

Genome-wide association studies (GWASs) have highlighted the importance of pleiotropy in human diseases, where one gene can impact 2 or more unrelated traits. Examining shared genetic risk factors across multiple diseases can enhance our understanding of these conditions by pinpointing new genes and biological pathways…

BACKGROUND: Component network meta-analysis (CNMA) enables disentangling individual component effects from multicomponent treatments. However, no established methods exist to quantify the contribution of evidence from constituent comparisons to the disentangled component effect estimates in CNMA, hindering the interpre…

Network meta-analysis (NMA) is an extension of pairwise meta-analysis that facilitates the estimation of relative effects for multiple competing treatments. A hierarchy of treatments is a useful output of an NMA. Treatment hierarchies are produced using ranking metrics. Common ranking metrics include the Surface Under…

BACKGROUND: Atypical Haemolytic Uremic Syndrome (aHUS) is a rare but life-threatening thrombotic microangiopathy. If inadequately managed, aHUS can lead to progressive kidney failure, cardiovascular complications and multiorgan dysfunction, resulting in high healthcare costs and a substantial impact on patients' qualit…

The accessibility of individual participant-level data (IPD) enhances the evaluation of moderation effects of patient covariates. It facilitates the provision of accurate estimation of intervention effects and confidence intervals by incorporating covariate correlations across multiple clinical trials. With a time-to-e…

INTRODUCTION: Life satisfaction is a key indicator of successful ageing and reflects well-being. There is evidence of the association between life satisfaction and health behaviours among older adults. Therefore, this systematic review and meta-analysis protocol seeks to determine the strength and direction of the asso…

The development of methods for the meta-analysis of diagnostic test accuracy (DTA) studies is still an active area of research. While methods for the standard case where each study reports a single pair of sensitivity and specificity are nearly routinely applied nowadays, methods to meta-analyze receiver operating char…