5,085,625 papers found

This report serves as a summary of a 2-day public workshop sponsored by the US Food and Drug Administration (FDA) to discuss the safety of drugs and biological products used during lactation. The aim of the workshop was to provide a forum to discuss the collection of data to inform the potential risks to breastfed infa…

This article summarizes recommendations reached following a systematic literature review and expert consensus on the diagnosis and management of cutaneous squamous cell carcinomas in people with epidermolysis bullosa. The guidelines are intended to help inform decision making by clinicians dealing with this complex com…

Wound care is a classic example of a surgical realm with a great variation in care. The diversity in wounds and wound treatments, the limited amount of convincing evidence, and the diverging opinions among doctors and nurses involved in wound care contribute to this undesirable variation in care. For chronic wounds, su…

PURPOSE: To provide clinicians with an evidence-based overview of all topics related to ultrasound vascular access. METHODS: An international evidence-based consensus provided definitions and recommendations. Medical literature on ultrasound vascular access was reviewed from January 1985 to October 2010. The GRADE and…

UNLABELLED: Sensory relearning (SR) first described in the 1970s by Wynn-Parry and Dellon has evolved over the last 20 years as a result of new insights into cortical plasticity. It has eluded precise definition, and a detailed description of its "key ingredients" is rarely documented in published studies investig…

The consensus conference on intracranial atherosclerosis provides a comprehensive review of the existing literature relevant to the epidemiology, diagnosis, prevention, and treatment of intracranial atherosclerosis, and identifies principles of management and research priorities. Patients who have suffered a stroke or…

SSRIs have achieved a high usage rate in the treatment of depression because of a similar efficacy to TCAs and a favourable safety and tolerability profile. However, SSRI use has been associated with bleeding. We reviewed the epidemiological evidence on the association between SSRI use alone and the risk of upper gastr…

To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) established the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS conse…

Many barriers to learning are present when teaching research methods. Developing, within students of nursing, the skills of reading and interpreting research reports is vital if the profession is to contribute to the general aim of achieving a sound basis for all health care interventions. This paper overviews the curr…

BACKGROUND: Perioperative oxygen administration has been proposed as a strategy to reduce postoperative complications. However, uncertainty exists as to which strategies are the most clinically effective. OBJECTIVES: To provide an overview on the effectiveness of perioperative oxygen therapy and formulate recommendati…

BACKGROUND: Stroma areactive invasion front area (SARIFA) was recently defined and introduced as a histomorphological, prognostic biomarker for various carcinomas. QUESTION: Current state of research and prospects for future developments. Report on the results of the consensus meeting. MATERIALS AND METHODS: Eva…

Since its release, ChatGPT, which is a novel artificial intelligence (AI) tool, has become a global phenomenon with its utilization in various fields of life. In particular, ChatGPT has many potential uses in the medical field, and its evidence base is expanding momentously. We thus aimed at synthesizing the evidence o…

OBJECTIVE: To summarize the use of Chinese Herbal Medicines (CHMs) for Idiopathic Pulmonary Fibrosis (IPF) and provide high-level evidence for clinical decisions. METHODS: We analyzed systematic reviews (SRs). Two English-language and three Chinese-language electronic databases were searched from inception to July 1,…

Several editions of the World Health Organization (WHO) classifications of lympho-hemopoietic neoplasms in 2001, 2008, and 2016 served as the international standard for diagnosis. Since the 4th WHO edition, here referred as WHO-HAEM4, significant clinico-pathological, immunophenotypic, and molecular advances have been…

BACKGROUND: Stroke is one of the leading causes of death and disability in the industrialized world and a large part of stroke survivors is of working age. A very important goal for these people is to return to work after stroke as it facilitates independent living and guarantees a high level of self-esteem and life sa…

AIM: To evaluate the effectiveness of non-pharmacological interventions for eating difficulties in people with dementia (PWD). BACKGROUND: Eat difficulties are common problems in PWD. Prolonged eating difficulties may lead to inadequate/excessive food and drink intake and other adverse outcomes. DESIGN: Overview of s…

PURPOSE: Testis cancer is the most common solid malignancy in young males. The purpose of this guideline is to provide a useful reference on the effective evidence-based treatment of early stage testicular cancer. METHODS: The systematic review utilized to inform this guideline was conducted by a methodology team at t…

BACKGROUND: The treatment of degenerative meniscal lesions has received increased attention since the publication of several Level 1 studies over the last few years. The following review of literature including the consensus statement given by ESSKA reports on the management of patients with degenerative meniscal…

Rapid and accurate diagnosis is critical for timely initiation of anti-tuberculosis (TB) treatment, but many people with TB (or TB symptoms) do not have access to adequate initial diagnosis. In many countries, TB diagnosis is still reliant on sputum microscopy, a test with known limitations. However, new diagnostics ar…

OBJECTIVE: Our objective was to develop a framework to identify research gaps from systematic reviews. STUDY DESIGN AND SETTING: We reviewed the practices of (1) evidence-based practice centers (EPCs), and (2) other organizations that conduct evidence syntheses. We developed and pilot tested a framework for identifyin…