44,776 papers found

INTRODUCTION: Neurosarcoidosis is a rare and severe manifestation of sarcoidosis, whose natural history still lacks a comprehensive and theoretical understanding. Therefore, we aimed to conduct a qualitative systematic review of the literature on the clinical-epidemiologic, diagnostic, and therapeutic assessment of pat…

BACKGROUND: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare but severe complication following solid organ transplantation (SOT). Currently, treatment regimens still lack clear guidelines. METHODS: A kidney transplant recipient with PCNS-PTLD was reported in this case s…

The association between central nervous (CNS) stimulants used to treat attention deficit hyperactivity disorder (ADHD) and Raynaud's phenomenon (RP) has received little attention to date. Our aim was to map the existing literature on aetiopathogenesis, clinical presentation and management of peripheral vasculopathy, wi…

PURPOSE: Spinal Cord Society (SCS) and Spine Trauma Study Group (STSG) established a panel tasked with reviewing management and prognosis of acute traumatic cervical central cord syndrome (ATCCS) and recommend a consensus statement for its management. METHODS: A systematic review was performed according to the PRISMA…

BACKGROUND: Central venous lines (CVLs) are frequently used in the management of many neonatal and pediatric conditions. Failure to remove the luminal part of the line (retained CVL) is rare. Consequently, there is lack of experience and consensus in its optimal management. AIM: To document the incidence and managemen…

BACKGROUND: Despite the efficacy of adaptive servo-ventilation (ASV) in suppressing central sleep apnea (CSA), its impact on long-term outcomes is debatable. We aim to identify subjects with specific features who might benefit from ASV therapy. METHODS: Randomized clinical trials and comparative observational studies…

OBJECTIVE: Radiation-induced sarcomas (RISs) of the central nervous system are an uncommon late risk of irradiation. We conducted a systematic review of individual patient data to characterize RISs. METHODS: We conducted a systemic search of the PubMed databases and compiled a comprehensive literature review. Student…

INTRODUCTION: The safety and effectiveness of stereotactic ablative radiotherapy (SABR) in patients with ultra-central lung tumors is currently unclear. We performed a systematic review to summarize existing data and identify trends in treatment-related toxicity and local control following SABR in patients with ultra-c…

BACKGROUND: The prevention of catheter-related bloodstream infections (CRBSI) is a critical priority in the clinical management of central venous catheters (CVCs). This meta-analysis aims to evaluate the efficacy of chlorhexidine gluconate antibacterial dressings in the context of CVC care. METHODS: A systematic liter…

BACKGROUND: Microorganisms can intraluminally access a central venous catheter via the catheter hub. The catheter hub should be appropriately disinfected to prevent central line-associated bloodstream infections (CLABSIs). However, compliance with the time-consuming manual disinfection process is low. An alternative is…

INTRODUCTION: A number of studies have reported an association between peripheral hearing impairment, central auditory processing and Alzheimer's disease (AD) and its preclinical stages. Both peripheral hearing impairment and central auditory processing disorders are observed many years prior to the clinical manifestat…

This document represents the American Society for Parenteral and Enteral Nutrition (ASPEN) clinical guidelines to describe best practices in the selection and care of central venous access devices (CVADs) for the infusion of home parenteral nutrition (HPN) admixtures in adult patients. The guidelines targeted adults >1…

OBJECTIVE: This systematic review aimed to evaluate the long-term outcomes of infants who had undergone fetal endoscopic tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH). METHODS: PubMed, MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception to…

INTRODUCTION: Root canal treatment (RCT) performed by undergraduate dental students is associated with procedural errors that may compromise outcomes. With the increasing use of rotary nickel-titanium (Ni-Ti) instrumentation, understanding these errors has become important; however, existing evidence remains fragmented…

Why are most hospitals or buildings of a rectangular design only? Compared to the standard rectangular Nightingale nursing unit design, why has a circular/elliptical nursing unit or hospital design not been developed to date? This study reexamines the concept of circular hospital building design. It aims to understand…

INTRODUCTION: The association between hallux valgus and pes planus remains controversial with debate focussing largely on the postulated pivotal role of 1st tarsometatarsal joint. This is the first systematic review to evaluate the importance of 1st TMT joint instability in the development, or recurrence, of hallux val…

: Traumatic spinal cord injury (SCI) frequently results in permanent motor and sensory deficits. Tumor necrosis factor-α is rapidly upregulated after SCI and contributes to secondary injury cascades, including microglial activation, cytokine amplification, and blood-spinal cord barrier disruption. Etanercept, a T…

OBJECTIVE: This study systematically evaluated and analysed existing evidence regarding the effectiveness of tinnitus retraining therapy (TRT) in treating tinnitus at different follow-up periods and the factors that influence the choice of treatment. DATABASES REVIEWED: Medline, OpenAIRE, Cochrane Central Register of…

: Many probiotic strains have been studied in relation to irritable bowel syndrome (IBS). The aim of this study was to identify probiotic strains demonstrating efficacy in the management of IBS based on meta-analyses of randomized placebo-controlled trials (RPCTs).: This systematic review was registered in the PROSPERO…

Enhanced Recovery After Surgery (ERAS) programmes have revolutionised perioperative care by integrating evidence-based, multimodal strategies aimed at minimising surgical stress, accelerating recovery, and reducing postoperative morbidity. This systematic review evaluates the impact of ERAS implementation on postoperat…