44,776 papers found

OBJECTIVE: This scoping review will map the existing literature on neurophysiological measures used to assess exercise-induced fatigue in athletes. INTRODUCTION: Exercise-induced fatigue, defined as a transient reduction in physical performance resulting from central and peripheral mechanisms, is a critical factor inf…

BACKGROUND: Non-small cell lung cancer (NSCLC) patients often develop brain metastases (BMs), with an incidence rate of 25-40%. These metastases are associated with a poor prognosis. Although immune checkpoint inhibitors (ICIs) have revolutionized NSCLC treatment, their effectiveness against BMs remains not well-establ…

BACKGROUND: Primary central nervous system T-cell lymphoma (PCNSTL) is an exceptionally rare central nervous system lymphoma with limited clinical data. We present a large case review series of PCNSTL to summarise the clinical characteristics of this disease. METHODS: This study integrated 4 new cases of PCNSTL from o…

BACKGROUND: Cochlear implantation (CI) has emerged as a promising intervention for children with auditory neuropathy spectrum disorder (ANSD). Several studies have investigated the efficacy of CIs in children with ANSD, demonstrating improvements in auditory performance and language skills following implantation. Wheth…

INTRODUCTION: Adrenergic neurotransmitter reuptake inhibitors are gaining attention in treatment for attention-deficit hyperactivity disorder (ADHD). Due to their effects on norepinephrine, dopamine, and serotonin neurotransmission, they benefit both ADHD and comorbid disorders and have some other advantages including…

Dedifferentiated chondrosarcoma (DDCS) is a high-grade subtype of chondrosarcoma with the bimorphic histological appearance of a conventional chondrosarcoma component with abrupt transition to a high-grade, non-cartilaginous sarcoma. DDCS can be radiographically divided into central and peripheral types. Wide resection…

OBJECTIVE: The purpose of this study was to evaluate the role of anti-vascular endothelial growth factor (anti-VEGF) treatment on the functional and structural parameters of chronic central serous retinopathy (CSR). METHODS: PubMed was used to systematically review literature published from 1 January 2009 to 1 July 20…

BACKGROUND: Primary central nervous system (CNS) sarcomas represent a heterogeneous group of rare neoplasms with unclear etiology. Available data on clinical characteristics, treatment strategies, and survival are scarce. We comprehensively reviewed management strategies and outcomes of primary CNS sarcomas in adults.…

BACKGROUND: Interposition arthroplasty of the first MTP joint has recently experienced renewed interest as a treatment for hallux rigidus. The purpose of this study was to systematically review the rapidly expanding literature on PRO following interposition arthroplasty of the first MTP joint. METHODS: PubMed Central,…

OBJECTIVE: Primary central nervous system lymphoma (PCNSL) is a specific type of non-Hodgkin lymphoma with poor prognosis. The rare incidence of this disease and difficulty to obtain sufficient tissue material impede deep research into PCNSL. However, application of modern molecular techniques makes it possible to find…

Decades of alcohol research have established the health risks and pharmacodynamic profile of oral alcohol consumption. Despite isolated periods of public health concern, comparatively less research has evaluated exposure to alcohol vapor. Inhaled alcohol initially bypasses first-pass metabolism and rapidly reaches the…

OBJECTIVE: This scoping review will map and characterize the systemic interventions used in family nursing across different health care settings and family types. INTRODUCTION: The family is considered a dynamic and complex system, in which changes to a single element influence the whole. Nurses adopt systemic interve…

Adults aged 75 years or older are increasingly considered for neurosurgical treatment of primary central nervous system tumors, yet the evidence guiding treatment selection remains fragmented. We conducted a scoping review of PubMed/MEDLINE, Ovid Embase, Scopus, and Web of Science from database inception through July 2…

OBJECTIVE: The objective of this review is to evaluate the effect of revision surgical strategies compared on functional outcomes, health-related quality of life, and postoperative complications in patients aged 65 years and older with failed primary fixation of trochanteric femoral fractures. INTRODUCTION: Trochanter…

BACKGROUND: To systematically evaluate the efficacy and safety of honey dressing compared to conventional dressings in the treatment of DFUs. METHODS: We conducted a systematic review and meta-analysis following PRISMA guidelines. PubMed, BIOSIS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Go…

BACKGROUND: Acute postoperative pain is one of the most common and painful complications of lung cancer patients undergoing video-assisted thoracoscopic surgery, which seriously affects the health and quality of life of patients. Although using medication for analgesia is the standard, their risk of adverse events stil…

BACKGROUND/OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome characterized by predisposition to tumors of parathyroid, pituitary, and enteropancreatic cells. Multiple studies previously showed increased prevalence of insulin resistance and incidence of cardiovascular diseases, decreased lif…

Antiretroviral therapy (ART) is an intervention aimed at preventing the development and spread of HIV. The persistence of proviruses in the CD4 + memory T cells, which are transcriptionally inactive and other drug-resistant reservoirs, makes treatment of chronic HIV-1 infection through pharmacological mea…

BACKGROUND: Adolescents are in a critical stage of development and represent a high-risk population for depression. Various studies have demonstrated the efficacy of acupuncture therapies in the treatment of adolescent depression. However, trials directly comparing the efficacy and safety of different acupuncture thera…

BACKGROUND: This study aims to evaluate the effectiveness of nasal conformers in patients with unilateral cleft lip and palate (UCLP) following primary cheiloplasty. METHODS: We conducted a comprehensive search in PubMed, EMBASE, the Cochrane Central Register of Clinical Trials (CENTRAL), and EBSCO Open Dissertation f…