44,768 papers found

BACKGROUND: A liver resection under low central venous pressure (CVP) has become standard practice; however, the benefits beyond a reduction in blood loss are not well reported. Moreover, the precise method to achieve CVP reduction has not been established. A systematic review and meta-analysis of randomized controlled…

INTRODUCTION: Ultrasound guidance has emerged as an adjunct for central vein catheterization in both adults and children. However, the use of ultrasound guidance for radial arterial catheterization has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of ultrasound g…

Radiation necrosis is a devastating complication following radiation to the central nervous system. The purpose of this study was to perform a comprehensive analysis of cases in the literature using bevacizumab, a monoclonal antibody against vascular endothelial growth factor, as treatment for radiation necrosis. A MED…

OBJECTIVE: Review the current evidence-based pharmacotherapy for phantom limb pain (PLP) in the context of the current understanding of the pathophysiology of this condition. DESIGN: We conducted a systematic review of original research papers specifically investigating the pharmacologic treatment of PLP. Literature w…

AIM: A systematic review was carried out to analyse continence at 2 years or more after lateral internal sphincterotomy (LIS) for chronic anal fissure (CAF). METHOD: PubMed, MEDLINE, Scopus, Embase, Ovid, SCI, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar were used to search the lite…

TOPIC: There is an ongoing debate among prescribers concerning the risk of inadvertently contributing to the initiation of substance abuse (SA) in children and adolescents through the use of stimulants in the treatment of attention-deficit/hyperactivity disorder (ADHD). Psychiatric nurses at all levels of practice must…

OBJECTIVE: The objective of the study was to obtain reliable data from recent surveys carried out in Italy on the prevalence of overweight (OW) and obesity (OB) in children. DESIGN: We searched in MEDLINE/Pubmed and Scopus. The keywords included "overweight ", "obesity", "children", "aged 6-11 years", "Italy", associa…

Recurrent urinary tract infections (rUTIs) are a common clinical problem affecting women worldwide. These infections significantly impair the quality of life, impacting social and sexual relationships, self-esteem, and work productivity. The escalating global threat of antimicrobial resistance necessitates a shift from…

INTRODUCTION: Methylphenidate is the most commonly prescribed first-line stimulant for managing Attention-Deficit/Hyperactivity Disorder (ADHD, yet concerns remain regarding its safety and potential impact on neurodevelopment during critical growth periods. AIM: To systematically review the literature in order to eval…

OBJECTIVE: This study aimed to assess the effectiveness of 12 interventions for postherpetic neuralgia (PHN) through direct and indirect comparisons using a network meta-analysis. These interventions included pulsed radiofrequency (PRF), high-voltage pulsed radiofrequency (HPRF), Long-Term PRF (LPRF), selective nerve b…

OBJECTIVES: Primary: To evaluate the diagnostic accuracy of point-of-care ultrasound for the identification of elbow fractures in pediatric patients. METHODS: We searched MEDLINE, PubMed, CINAHL, and Cochrane Central Register of Controlled Trials (CENTRAL) up until December 1, 2025 for studies involving pediatric pati…

BACKGROUND: Pain is a common and clinically relevant symptom during chemotherapy for breast cancer, negatively affecting quality of life. Although physical exercise is recommended and considered safe during chemotherapy, it may acutely exacerbate pain while potentially reducing it in the long term. Therefore, this stud…

To assess available evidence on the association between anxiety and caffeine consumption in healthy individuals. A high-sensitivity electronic search was performed, as recommended by the Cochrane Handbook, which underwent peer review according to the PRESS Guide, in March 2021 in the following databases: Cochrane Libra…

PURPOSE: The objective of this study was to systematically review the effectiveness of thoracic-focused interventions, including breathing exercises and thoracic manual techniques (mobilization, high-velocity low-amplitude manipulation, and release techniques), on pain and disability in patients with low back pain (LBP…

Research on female subjects in sports science remains insufficient, particularly regarding how plyometric training affects adult female athletes' jumping, sprinting, and change-of-direction (COD) performance. This gap has prevented definitive conclusions about the magnitude and characteristics of such performance effec…

Microneedling, a minimally invasive dermatologic procedure, has expanded beyond cosmetic use to treat conditions such as vitiligo, hyperhidrosis, melasma, acne vulgaris, and actinic keratoses. This systematic review, conducted in accordance with PRISMA guidelines, included 15 randomized controlled trials involving appr…

This systematic review evaluates the impact of intraoperative imaging on surgical outcomes in combined neurosurgical and reconstructive procedures. A comprehensive literature search was conducted across four databases, including PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials (CEN…

OBJECTIVE: To better understand the relationship between traumatic brain injury (TBI) and obstructive sleep apnea (OSA). DATA SOURCES: PubMed, Web of Science, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched in May 2025 for studies reporting sleep-apnea data from sleep studies in a tr…

Anticoagulant therapy plays a pivotal role in preventing stroke and thromboembolic complications in elderly patients with atrial fibrillation, a population at increased risk for both ischemic and bleeding events. This systematic review evaluates the comparative efficacy and safety of direct oral anticoagulants (DOACs)…

PURPOSE: The aim of the present review was to critically evaluate recent studies to determine the optimal combination of anaesthetic technique and agent for achieving effective anaesthesia in molar incisor hypomineralisation (MIH) patients, thereby addressing a significant need in evidence-based clinical practice. The…