5,086,189 papers found

Almost every aspect of myalgic encephalomyelitis (or encephalopathy) and chronic fatigue syndrome is the subject of disagreement and uncertainty -- something that has undoubtedly hampered recognition, understanding and research. Although the pathogenesis remains the subject of intense medical debate, a number of predis…

The vasculitides commonly create diagnostic and management problems, and a biopsy diagnosis of vasculitis usually does not stand alone in the proper medical management of a patient. Indeed, a conclusive diagnosis usually cannot be made without correlation with the patient's clinical history, physical findings, and/or a…

Clinicians must not simply decide that a patient with symptoms and a positive diagnostic test has a reason for a specific treatment, and likewise clinicians must not decide that a patient with symptoms and a negative test does not have a clinically important problem. We must also consider the sensitivity, specificity a…

The 1991 Consensus Development Panel was instrumental both in establishing criteria for selection of patients for surgical treatment and in recognition of operations that have been shown to be safe and reasonably effective in the long term. The Panel may have been premature in endorsement of any form of banded gastropl…

OBJECTIVE: To identify, critically evaluate and synthesize the evidence obtained from systematic reviews on the association between genetic polymorphisms and osteoarthritis (OA) development. METHODS: Considering gene polymorphisms associated with OA susceptibility (risk or protection), a comprehensive search was condu…

BACKGROUND: To explore effectiveness and acceptability of non-pharmacological interventions in mild cognitive impairment (MCI). METHODS: Overview of systematic reviews and network meta-analysis were conducted. Systematic reviews (SRs) were searched via seven databases from June 2015 to June 2020. Randomized controlled…

OBJECTIVES: Our study aimed to systematically assess and report the methodological quality used in epidemiological systematic reviews (SRs) and meta-analysis (MA) of pathogen genotypes/genogroups. STUDY DESIGN AND SETTING: Nine electronic databases and manual search of reference lists were used to identify relevant st…

Observational vaccine effectiveness (VE) studies provide essential real-world evidence but are prone to bias. Valid synthesis relies on rigorous risk-of-bias (RoB) assessment in systematic reviews of VE studies. Following JBI guidance, we mapped and described RoB assessment methodologies in systematic reviews of VE stu…

Obesity is a chronic non-communicable disease; that significantly impacts cardiovascular health via related conditions such as hypertension, diabetes, and coronary artery disease. Bariatric surgery provides effective weight loss, however exercise's cardiometabolic benefits post-surgery remain underexplored. To gain dee…

INTRODUCTION: Bone marrow aspirate concentrate (BMAC) is increasingly used in orthopaedics for its regenerative potential. As clinicians rely on systematic reviews and meta-analyses to guide clinical decision making, concerns remain regarding methodologic rigor and reporting bias (spin). This study evaluated the preval…

INTRODUCTION: Community- and population-level and policy interventions are commonly evaluated using nonrandomized studies (NRS), rather than randomized trials (RCTs). Recent Cochrane reviews of interventions for preventing childhood obesity have been restricted to RCTs, so less is known about the effectiveness of these…

PURPOSE: This guideline aimed to make evidence-based clinical practice guidelines for the primary treatment of temporomandibular disorders (TMDs) for general practitioners who do not specialize in TMD. REVIEW PROCESS: Following the principles of evidence-based medicine, a systematic review and network meta-analysis (N…

OBJECTIVES: The scientific literature contains an abundance of prediction models for hospital readmissions. However, no review has yet synthesized their predictors across various patient populations. Therefore, our aim was to examine predictors of hospital readmissions across 13 patient populations. STUDY DESIGN AND S…

To date, several systematic reviews and meta-analyses (SRMA) have investigated the effects of probiotics, but the certainty of the evidence for an effect on chemotherapy and radiotherapy-related diarrhoea has not been assessed. We conducted an overview of SRMA, searching MEDLINE, Scopus, and ISI Web of Science from inc…

AIMS: Facilitated self-management support programmes have become central to the treatment of chronic diseases including diabetes. For many children and young people with diabetes (CYPD), the impact on glycated haemoglobin (HbA) and a range of self-management behaviours promised by these programmes remain unrealised. Th…

: Consequences due to infection with SARS-CoV-2 virus can have a direct impact on skeletal muscle, due to the fact that both cardiac and skeletal muscle tissue show robust ACE2(angiotensin-converting enzyme 2) expression, suggesting a potential susceptibility to SARS-CoV-2 infection in both types of tissues. From the a…

Introduction: Armed conflicts affect the mental health of children and adolescents. Their outcomes in these populations have been documented identifying vulnerability and significant biopsychosocial damage as the most common factors. Objective: To identify and synthesize the mental health consequences of armed conflict…

Hepatitis C virus and chronic kidney disease are major public health issues all over the world and controversy persists regarding the role of Hepatitis C as a risk factor for the development of chronic kidney disease in the adult general population. Numerous studies found a relationship between positive anti-HCV antibo…

BACKGROUND: Sertoli cell tumors (SCTs) of the testes are rare, and the literature provides only weak evidence concerning their clinical course and management. The objective of this study was to summarize evidence on SCTs' clinical presentation, clinicopathological risk factors for malignancy, treatment options, and onc…