4,998,788 papers found

BACKGROUND: Persistent levels of low-grade inflammation and T lymphocyte activation are associated with insulin resistance and type 2 diabetes that eventually lead to the development of cardiovascular diseases. Interestingly, increasing studies report on an emerging role of innate lymphoid cells in the development of b…

Searching multiple resources to locate eligible studies for research syntheses can result in hundreds to thousands of duplicate references that should be removed before the screening process for efficiency. Research investigating the performance of automated methods for deduplicating references via reference managers a…

BACKGROUND: Breast cancer and its treatment can have many physical and psychological effects on affected women. Women's personal goals may provide insight into their priorities and motivations in the context of breast cancer. Incorporating personal goal-setting into support and care interventions may have an effect on…

INTRODUCTION: The global burden of conduct disorder is considerable, particularly in males. Deaths were followed by conflict and terrorism increased 143·3% from 2006 to 2016. The objective of this study is to provide a protocol of systematic review and meta-analysis to update the global prevalence of conduct disor…

INTRODUCTION: The transition from hospital to home is a vulnerable stage in the patient pathway. Patients and carers often report unmet information needs regarding diagnoses, medication changes, follow-up arrangements and escalation pathways during the post-hospital discharge period. Digital information interventions-s…

BACKGROUND: Socioeconomic determinants of health (SDoH) have a significant impact on healthcare, health outcomes, and resulting health inequalities. A wealth of research relating to the adult population exists, including those with long-term health conditions. However, research is lacking on the impact of these SDoH on…

INTRODUCTION: Human actions have influenced climate changes around the globe, causing extreme weather phenomena and impacting communities worldwide. Climate change has caused, directly or indirectly, health effects such as injury and physical injuries, which impact morbidity and mortality. Similarly, there is evidence…

BACKGROUND: Because of the enormous social and economic burden of disease, the prevention of mild cognitive impairment and Alzheimer's-type dementia has become a major global public health priority. Studies show that cognitively stimulating activities during middle adulthood might have a protective effect on the brain…

The systematic review of evidence is the research method which underpins the traditional approach to evidence-based healthcare. There is currently no uniform methodology for conducting a systematic review of association (etiology). This study outlines and describes the Joanna Briggs Institute's approach and guidance fo…

Evidence synthesis is the concern of this column. Both quantitative and qualitative evidence synthesis are considered using the Cochrane and Joanna Briggs Institute protocols as a means of explanation. Finally, issues related to qualitative synthesis are entertained.

BACKGROUND: Domestic violence is one of the most significant global public health priorities. This social problem could be accelerated by global catastrophes such as the COVID-19 pandemic. The structural changes due to the imposition of health measures, combined with personal and social problems, may worsen the situati…

BACKGROUND: Stroke is a major cause of global mortality and disability. Currently, the treatment of acute ischaemic stroke through reperfusion has posed several challenges, raising the need for complementary options to protect the ischaemic penumbra. Recent investigations have indicated that certain epigenetic factors,…

BACKGROUND: Spinal cord injury (SCI) is one of the most disabling neurological conditions, afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species scavenger, is expanding its new scope in field of SCI. The objective of this systematic review is to determine the neuroprotective effects and…