Evaluating and improving real-world evidence with Targeted Learning.
Gruber Susan, Phillips Rachael V, Lee Hana, +2 more·BMC medical research methodology
BACKGROUND: The Targeted Learning roadmap provides a systematic guide for generating and evaluating real-world evidence (RWE). From a regulatory perspective, RWE arises from diverse sources such as randomized controlled trials that make use of real-world data, observational studies, and other study designs. This paper…