382,703 papers found

Genome-wide association studies (GWAS) have been used to establish thousands of genetic associations across numerous phenotypes. To improve the power of GWAS and generalize associations across ethnic groups, transethnic meta-analysis methods are used to combine the results of several GWAS from diverse ancestries. The g…

INTRODUCTION: Adverse events following the injection (AEFIs) of human papillomavirus vaccine (HPVv) among female adolescents are still a major public health concern. METHODS: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension statement for systematic reviews incorporating net…

Calls for empirical investigations of the Common Core standards (CCSSs) for English Language Arts have been widespread, particularly in the area of text complexity in the primary grades (e.g., Hiebert & Mesmer Educational Research, 42(1), 44-51, 2013). The CCSSs mention that qualitative methods (such as Fountas and Pin…

BACKGROUND: A child's risk of dying is highest in the neonatal period, i.e. the first 28 days of life. Newborn death accounts for nearly half of under-five death. More than 80% of newborn deaths are the result of preventable and treatable conditions. Ethiopia has made significant progress towards reducing under-…

Small-study effects are a common threat in systematic reviews and may indicate publication bias. Their existence is often verified by visual inspection of the funnel plot. Formal tests to assess the presence of funnel plot asymmetry typically estimate the association between the reported effect size and their standard…

Theta burst stimulation (TBS) has been proposed as a novel treatment for major depression (MD). However, randomized and sham-controlled trials (RCTs) published to date have yielded heterogeneous clinical results and we have thus carried out the present systematic review and exploratory meta-analysis of RCTs to evaluate…

INTRODUCTION: Osteoporotic vertebral compression fractures (OVCFs) commonly cause both acute and chronic back pain, substantial spinal deformity, functional disability and decreased quality of life and increase the risk of future vertebral fractures and mortality. Percutaneous vertebroplasty (PVP), balloon kyphoplasty…

In meta-analyses, where a continuous outcome is measured with different scales or standards, the summary statistic is the mean difference standardised to a common metric with a common variance. Where trial treatment is delivered by a person, nesting of patients within care providers leads to clustering that may interac…

BACKGROUND: Converging evidence demonstrates the important role of the neuropeptide hormone oxytocin (OT) in human behaviour and cognition. Intranasal OT administration has been shown to improve several aspects of social communication, such as the theory of mind performance and gaze to the eye region, and reduce anxiet…

BACKGROUND: Cytomegalovirus (CMV) reactivation in critically ill patients is a well-recognized phenomenon with an incidence as high as 71 %. A number of studies have investigated the association between CMV reactivation and outcomes in critically ill patients with conflicting results. We propose to conduct a syste…

BACKGROUND: Systematic review and meta-analysis (SRMA) are increasingly employed in environmental health (EH) epidemiology and, provided methods and reporting are sound, contribute to translating science evidence to policy. Ambient air pollution (AAP) is both among the leading environmental causes of mortality and morb…

Evidence based medicine has preferably been based on prospective randomized controlled trials (PRCT's) and subsequent meta-analyses in many fields including nutrition and metabolism. These meta-analyses often yield convincing, contradictory or no proof of effectiveness. Consequently recommendations and guidelines of va…

In genome-wide association studies of binary traits, investigators typically use logistic regression to test common variants for disease association within studies, and combine association results across studies using meta-analysis. For common variants, logistic regression tests are well calibrated, and meta-analysis o…

Using a metascience framework for improving meta-analyses, Jansen et al. (2025) tested the accuracy and efficiency of data extraction from primary studies used in meta-analyses with a range of large language models. Efficiency was impressive: Across thousands of studies and hundreds of variables, eight large language m…

Kalhor et al. (2025) conducted a systematic review and meta-analysis on predictors of exclusive breastfeeding, offering valuable insights but facing methodological challenges. Despite a robust search strategy, PROSPERO registration, and use of the Newcastle-Ottawa Scale, heterogeneity remained high (I² >85%), with…

Meta-analysis assigns more weight to studies with smaller standard errors to maximize the precision of the overall estimate. In observational settings, however, standard errors are shaped by methodological decisions. These decisions can interact with publication bias and p-hacking, potentially leading to spuriously pre…

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary To assess the comparative benefits and harms of immunomodulators and immunosuppressants for people with generalised myasthenia gravis through a network meta-analysis. Secondary To estimate the relative ranking of immunomodul…

BACKGROUND: Lung ultrasound has been used more and more in clinical diagnosis of acute heart failure (AHF) in recent years. The purpose of this paper is to evaluate the diagnostic value of lung ultrasound in AHF by meta-analysis. METHODS: PubMed, Cochrane Library, Web of Science, and Embase were searched. The time lim…

PURPOSE: This tutorial will provide speech-language pathologists with practical considerations and pragmatic tools for interpreting and critically evaluating a meta-analysis. Meta-analysis, which is a statistical procedure that involves combining research data across multiple high-quality research studies, is often con…

. Cultural meta-analysis 2: the after Covid-19. Against the background of the promises-expectations of an ethically and ecologically renewed and resilient world (declared needed to compensate and to avoid the repetition of the pandemic tragedy), the same methodology proposed in the heart of the Covid scenario has been…