5,087,135 papers found

Histopathological classification schemes provide the underpinnings for separating idiopathic interstitial pneumonias into clinically meaningful groups. An interdisciplinary classification system based on a combination of evidence and expert opinion was published in 2002 and set the stage for controversy in several area…

In recent years, bariatric surgery has enjoyed a high level of approval. There are several technical and surgical options. Most of the departments of obesity surgery perform usually the same procedure, when just in a few center the procedure can be adapted depending on the patient need. In this paper the most popular t…

A growing body of evidence suggests that there is a close correlation between good glucose control and improved clinical outcomes in hospitalized diabetic patients. Until recently, however, no established standards have existed for caring for people with diabetes in the hospital. At a recent consensus conference, exper…

(1) Acupuncture has been assessed in hundreds of published comparative trials involving thousands of patients in a variety of situations. (2) Most of these trials are handicapped by their poor methodological quality. (3) Systematic reviews have found evidence of specific benefit in the treatment of nausea and vomiting,…

High blood pressure is frequently seen in family practice. In response to recent surveys and clinical trials, the Canadian Hypertension Society has changed its recommendations on the management of HBP. This article reviews family physicians' approach to HBP according to the recent report of the Canadian Hypertension So…

Effectiveness research aims to base medical decision making more on rigorous evidence than on intuition and anecdote. The methods used to generate new data include, in order of decreasing rigor, clinical trials, observational studies, claims data analysis, and anecdotal studies. The methods that synthesize existing dat…

OBJECTIVE: To critically evaluate published and unpublished systematic reviews and meta-analyses on the safety and efficacy of methylenedioxymethamphetamine-assisted psychotherapy for post-traumatic stress disorder. METHODS: Six bibliometric databases and grey literature were searched from inception to 9 May 2024 for…

UNLABELLED: WHAT IS KNOWN ON THE SUBJECT?: Reminiscence therapy is a common psychosocial intervention in mental health nursing. Numerous secondary studies have explored the effects of reminiscence therapy interventions in older adults, and while the effects are significant, conflicting results remain. WHAT THIS PAPER A…

OBJECTIVES: We developed the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up of germ cell tumours (GCT) of the testes in adult patients. We present the guideline content in 2 separate publications. The present second part summarizes therecommendations for the treatme…

Clubfoot is one of the most common congenital anomalies, affecting every 1 of 1000 live births in the UK. Historically, clubfeet have been managed with a variety of conservative and operative techniques. Over the last two decades, the Ponseti serial casting method has become the gold standard of treatment. In July 2021…

PURPOSE: To define unmet needs in ophthalmology that can realistically be addressed in the next 5 years (2019-2025) and describe potential avenues for research to address these challenges. METHODS: Outcomes of a consensus process within the European Vision institute (Brussels) are outlined. Disease areas that are disc…

Optimistic predictions that genetic and genomic testing will provide health benefits have been tempered by the concern that individuals who receive their results may experience negative psychosocial outcomes. This potential ethical and clinical concern has prompted extensive conversations between policy-makers, health…

Following the release of the Ministerial Taskforce on Nursing in August 1998 and the withdrawal of the New Zealand Nurses Organisation from the Taskforce membership, a 'decision-making' workshop was held to further advance nursing practice roles in New Zealand. Momentum about advanced nursing roles had been gathering s…

LEARNING OBJECTIVES: After studying this article, the participant should be able to: 1. Understand and describe the physiology of pressure sore development. 2. Understand and describe population risk factors. 3. Understand and describe examination and classification. 4. Understand and describe common surgical treatment…

Effector mechanisms in anaphylaxis were reviewed. Current approaches to confirmation of the clinical diagnosis were discussed. Improved methods for distinguishing between allergen sensitization (which is common in the general population) and clinical risk of anaphylaxis (which is uncommon) were deliberated. Innovative…

Clopidogrel combined with aspirin is the mainstay of antiplatelet therapy for patients who present with acute coronary syndromes as well as following either bare metal or drug-eluting stent placement. Limitations of clopidogrel therapy include the relatively long time course required to achieve maximal inhibition of pl…

Increasingly, individuals are turning to complementary therapies to reduce or cope with chronic pain. Acupuncture, one of the oldest complementary therapies, originated from China more than 2500 years ago. It has steadily gained popularity in the United States over the last few decades as a modality for pain relief amo…