11,356,020 papers found

BACKGROUND: Recent results from the Dutch NELSON study have rekindled debates about the benefit-to-harm ratio of lung cancer screening and the comprehension of this by physicians. METHODS: This research surveyed the perception and understanding of 136 Austrian physicians regarding the advantages and risks of lung canc…

Nationally, the 18-49 years old age group are less likely to be vaccinated compared to those 50 years and older. Data describing the risk of COVID-19 severe illness that requires hospitalization among younger healthy adults is limited. In an effort to underscore the importance of vaccination and provide data…

BACKGROUND: The opioid epidemic remains a public health crisis and most people with opioid use disorder (OUD) do not receive effective treatment. The emergency department (ED) can be a critical entry point for treatment. EDs are developing and implementing ED-based efforts to address OUD to improve access to OUD treatm…

In this cross-sectional study, we evaluated data from the 2014 Bangladesh Demographic and Health Survey (BDHS), which consisted of 7,707 married women aged 15-49 years who lived with at least one child younger than 5 years. This study's primary aim was to examine the relationship between maternal high-risk fertility be…

BACKGROUND: Apathy is a common and debilitating symptom accompanying many neurological disorders including non-traumatic subarachnoid hemorrhage (SAH). OBJECTIVES: The aim of this systematic review was to identify and critically appraise all published studies that have reported the prevalence, severity, and time cours…

Long-term cancer survivorship care is a crucial component of an efficient healthcare system. For numerous reasons, there has been an increase in the number of cancer survivors; therefore, healthcare decision-makers are tasked with balancing a finite budget with a strong demand for services. Decision-makers require clea…

STUDY DESIGN: Randomized-controlled trials (RCTs), prospective cohort, case-control, pre-post studies, and case reports that assessed pharmacological and non-pharmacological intervention for the management of the neurogenic bowel after spinal cord injury (SCI) were included. OBJECTIVE: To systematically review the evi…

Human S-adenosylmethionine decarboxylase is synthesized as a proenzyme that undergoes an autocatalytic cleavage reaction generating the alpha and beta subunits and forming the pyruvate prosthetic group, which is derived from an internal Ser residue (Ser-68). The mechanism of this processing reaction was studied using s…

The expression of most Staphylococcus aureus virulence factors is controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr-encoded autoinducing peptide (AIP). A polymorphism in the amino acid sequence of the AIP and of its corresponding receptor divides S. aureus st…

Cardiovascular disease is a worldwide epidemic in terms of mortality. It is especially serious in Western countries with heart disease, surpassing even cancer in mortality. Although our understanding of how to prevent and treat the traditional cardiovascular risk factors is largely known, cardiovascular disease still r…

BACKGROUND: Resource allocation and access to comprehensive treatment in the public healthcare sector are always under pressure. This pressure takes the form of staff shortages, treatment models and the holistic care of patients, compromising basic healthcare in South Africa. OBJECTIVES: The study's aim was to determi…

Early diagnosis and access to behavioral health services can improve the health outcomes for young children suffering from mental illness. Often, children and their families' behavioral health needs are not met due to a broken local system of care. Developing a deep understanding of the situation by exploring all stake…

Obesity has become a significant global health issue. This multifaceted condition is influenced by genetic, environmental, and lifestyle factors, significantly influenced by nutrition.: The study's objective is to elucidate the relationship between obesity-related genes, nutrient intake, and the development of obesity…

Failures of inhibitory control can severely affect everyday life in healthy individuals and represent a common feature of many neuropsychiatric conditions, particularly disorders with dopaminergic disturbances implicated. This study's aim was to examine the interacting influences of three common and functional gene var…

PURPOSE: To comprehensively map the types of assistive devices implemented for children with developmental coordination disorder (DCD), regardless of setting, and clarify the methodologies used in these interventions. Specifically, we sought to answer the following questions: (1) What types of assistive devices are ava…

INTRODUCTION: Both type 2 diabetes mellitus (T2DM) and schizophrenia are known to be associated with cognitive deficits. The impact of the comorbidities of T2DM or prediabetes (PD) on cognition among people with schizophrenia has been poorly researched. We evaluated the cognitive functioning of patients with schizophre…

OBJECTIVES: To elucidate changes in depressive symptoms after bereavement and the impact of pre-loss resilience on such changes and on the extent of complicated grief and posttraumatic growth. METHODS: Prospective cohort surveys were provided to family caregivers of patients with cancer in four palliative care units (…

OBJECTIVE: This study's objective was to investigate whether use of an electronic dietary recording system improves nutrition knowledge, eating attitudes and habitual physical activity levels compared to use of a food diary and no self-monitoring. METHODS: Sixty adults aged 20-60 with a body mass index ≥25 were…

This research investigates the critical, under-examined nexus of geopolitical risk, environmental quality (CO2 emissions), and public health in BRICS countries. Employing pooled and quantile regression estimators for panel data, the study reveals that geopolitical risk is positively associated with environmental qualit…

Mass-produced tourism souvenirs often dilute the cultural integrity of heritage sites, yet the mechanisms by which design philosophy and ethics sustain authenticity remain underexplored. This study investigates how designers' philosophical stances and ethical practices shape authentic Dunhuang souvenirs. Adopting a qua…