Change in erythropoietin pharmacokinetics following hematopoietic transplantation.
Widness J A, Schmidt R L, Hohl R J, +4 more·Clinical pharmacology and therapeutics
Pre-clinical studies have demonstrated that bone marrow ablation has a profound effect in decreasing erythropoietin (EPO) elimination. The study's objective was to determine in humans if EPO pharmacokinetics (PKs) are perturbed following bone marrow ablation. EPO PK studies were performed in eight subjects, aged 4 to 6…