5,011,552 papers found

Since 1986, published from the P. Pignoli's group in Italy, the measurement by B-Mode Ultrasound of the carotid Intima Media Thickness is considered a very important tool for the assessment of cardiovascular risk in epidemiological trials but also for pharmacological studies. After more than 20 years the improvement of…

In 2003, The National Academy of Clinical Biochemistry published a consensus monograph on thyroid tests (available via Internet from 2002). The document, a result of international collaboration, describes the pathophysiological background and clinical application of the measurements as well as principles for their tech…

Results from many randomized trials of adjuvant breast cancer therapy have been presented in several overviews and at subsequent meetings. This manuscript reviews the current status of both chemo- and endocrine therapy and the prospects for combination therapy, as summarized at the NIH and St Gallen Consensus meetings.…

The first episode of nephrolithiasis provides an opportunity to advise patients about measures for preventing future stones. Low fluid intake and excessive intake of protein, salt and oxalate are important modifiable risk factors for kidney stones. Calcium restriction is not useful and may potentiate osteoporosis. Dise…

The report of the Canadian Cardiovascular Society's Consensus Conference on the diagnosis and management of heart failure was published in 1994. Focusing on the chronic medical treatment of patients with systolic left ventricular dysfunction, we summarize and update the consensus recommendations in the light of the res…

BACKGROUND: Antibiotics provide only modest benefit in treating sore throat, although their effectiveness increases in people with positive throat swabs for group A beta-haemolytic streptococci (GABHS). It is unclear which antibiotic is the best choice if antibiotics are indicated. This is an update of a review first p…

BACKGROUND: Ventricular arrhythmias (VAs) are a significant contributor to morbidity and mortality in patients with acute heart failure (AHF), yet their management has been underrepresented in current guidelines. OBJECTIVE: To highlight and critically evaluate the key recommendations of the 2024 ACVC-EHRA-HFA consensu…

An overview of reviews aims to collect, assess, and synthesize evidence from multiple systematic reviews (SRs) on a specific topic using rigorous and reproducible methods. An important methodological challenge in conducting an overview of reviews is the management of overlapping data due to the inclusion of the same pr…

It seems paradoxical that facts, data and science are still considered controversial despite the harrowing death of a multitude of people from coronavirus disease 2019 (COVID-19), an unparalleled health care crisis of our lifetime. In addition, while scientists are desperately attempting to produce a vaccine for COVID-…

The analysis of publications devoted to the Russian Consensus on the Diagnostic and Treatment of Autoimmune Hepatitis (AIH), which was considered at the 43rd annual Scientific Session of the CNIIG From Traditions to Innovation (March 4, 2017) is carried out. The presence of clear algorithms and recommendations for the…

UNLABELLED: Despite extensive use of the term 'standard of care' (SOC), there is no such medical definition. How are neonatal therapies accepted as SOC with huge centre-to-centre variation? What defines SOC? We will consider paths to acceptance of multiple therapies (antenatal corticosteroids, preventing GBS, others).…

2001 French guidelines on the modalities of post-detoxification care for alcohol-dependent patients recommend life-long abstinence from alcohol. Though experts of this conference have used a methodological tool based on the analysis of the literature for each specific issue, the recommended goal of abstinence only foll…

In 2006, a task force of 50 specialists sponsored by the European Society for Paediatric Endocrinology (ESPE) and the Lawson Wilkins Pediatric Endocrine Society (LWPES) devised a Consensus Statement outlining the recommendations for the management of disorders of sex development (DSDs; then referred to as 'intersex' di…

Breast cancer detection and staging are constantly evolving as technologies improve. Breast cancer surgery is also undergoing continuous refinement, with the objective being to achieve optimal cosmetic results. Surgery has been combined with intraoperative radiation therapy to achieve the best local-disease control wit…

Different standards and levels of evidence for evaluating the effectiveness of psychological interventions for managing distress in cancer patients are presented and discussed. We conclude that the strongest evidence comes from systematic qualitative and quantitative (i.e., meta-analyses) reviews of the relevant litera…

Shoulder involvement is usually inconspicuous in patients with rheumatoid arthritis, and the clinical manifestations are nonspecific. Nevertheless, shoulder involvement should be sought routinely and detected early. Range of motion at the shoulder should be evaluated. Although normal radiographic findings do not rule o…

Purpose To review published literature on the clinical efficacy, use, and accuracy of the 31-gene expression profiling (31-GEP) test for prognostic information in invasive melanoma. Methods A comprehensive literature search used keywords "31-gene expression profiling," "melanoma," "prognosis," "clinical efficacy," and…

Emotional symptoms, particularly anxiety and depression, are common in COPD patients but are often under-managed. This study aimed to synthesize evidence on non-pharmacological interventions for these symptoms in COPD. An umbrella review of guidelines, systematic reviews, and expert consensus was conducted. Literature…

BACKGROUND AND OBJECTIVES: Numerous studies have assessed the adherence of published systematic reviews to the PRISMA 2020 statement. We aimed to summarize the characteristics and methods of development of the tools used to assess adherence in these studies. METHODS: MEDLINE, Embase, and PsycINFO (all via Ovid) were s…

In allogeneic haematopoietic stem cell transplantation (HSCT), important clinical decisions depend upon assessment of chimerism, including immunosuppressant dosing and donor lymphocyte infusions (DLI), which in turn can have major impacts on disease control, graft-versus-host disease (GVHD), immunity and ultimately pat…