375,970 papers found

With the use of data published during the period from 1966 through 1988, a pooled analysis (meta-analysis) of 5-year mortality rates among patients who had an eye enucleated for choroidal melanoma was performed to provide a more robust estimate of this rate than could be obtained from any single study. The literature c…

Lactitol (beta-galactosido-sorbitol) has been recently compared with lactulose for the treatment of chronic hepatic encephalopathy in a few studies, each comprising a small number of patients. The results are controversial. We studied the efficiency and tolerance of both compounds by using a meta-analysis on the basis…

Bleeding from oesophageal or gastric varices is a major complication of portal hypertension, and a leading cause of death in patients with liver cirrhosis. The efficacy of oral beta-blockers in preventing recurrence of gastrointestinal haemorrhage in these patients is debatable. A recent meta-analysis showed benefits i…

This study was intended to answer two questions: 1) whether the prognosis of patients with dilated cardiomyopathy and myocardial inflammatory changes, and 2) whether immunosuppressive agents may modify survival. The meta-analysis technique was employed as a tool in order to homogenize the results of several reports tha…

Despite numerous controlled clinical trials, the indications for parenteral nutritional support of cancer patients undergoing chemotherapy remain controversial. The results of the published trials have therefore been subjected to meta-analysis. The pooled data show that total parenteral nutrition (TPN) has a detrimenta…

BACKGROUND: To evaluate the effectiveness of virtual reality (VR) devices with different immersion levels on procedure-related pain in children through network meta-analysis. METHODS: We systematically searched multiple databases for randomized controlled trials comparing VR interventions versus standard care for mana…

BACKGROUND: Multiple randomized controlled trials (RCTs) of biologics for chronic rhinosinusitis with nasal polyps (CRSwNP) have expanded treatment options. This network meta-analysis (NMA) aimed to synthesize available evidence to compare the efficacy of these biologics. METHODS: A systematic literature search was co…

OBJECTIVE: To compare and rank the effects of different mind-body exercise interventions on psychological and physical outcomes in individuals with type 2 diabetes mellitus using a network meta-analysis. METHODS: This study systematically searched PubMed, Embase, Web of Science, and the Cochrane Library, and conducted…

OBJECTIVE: The effects of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) on the motor symptoms in Parkinson's disease (PD) were evaluated using a network meta-analysis (NMA). METHODS: Studies (1 January 2003-1 January 2025) from four databases were screened for analyses. A Bayesi…

OBJECTIVE: To evaluate the effectiveness and safety of multiple acupuncture therapies in the treatment of allergic rhinitis (AR) using a network Meta-analysis. METHODS: This network Meta-analysis adhered to the PRISMA-NMA guideline. Eight databases were systematically searched from inception to December 31, 2023, and…

OBJECTIVE: This study aims to evaluate and compare the relative efficacy and safety of acupuncture and moxibustion interventions for the recovery of gastrointestinal function and the incidence of adverse reactions after gastrointestinal cancer (GIC) surgery. METHODS: Eight databases were retrieved up to July 2025. The…

Multiple exercise modalities are recommended for older adults, yet their comparative effectiveness remains uncertain. We conducted a Bayesian network meta-analysis of randomized trials to compare common exercise modes on cardiorespiratory fitness and metabolic health in adults aged ≥55 years. Trials rando…

OBJECTIVE: This study aimed to synthesize existing evidence comparing telemedicine with usual care and to examine the relative effectiveness of different telemedicine strategies in the management of asthma among adults. METHODS: A systematic search of MEDLINE/PubMed, Cochrane Library, Web of Science, and Scopus identi…

BACKGROUND: Plantar fasciitis (PF) is the most common cause of heel pain, often causing significant disruptions to daily life due to severe discomfort. Multiple clinical investigations have attested to the efficacy of injection therapies. This network meta-analysis aimed to evaluate and compare the therapeutic effects…

BACKGROUND AND OBJECTIVES: As biologic therapy is increasingly being utilized in the treatment of paediatric psoriasis, we aim to perform a systematic review and network meta-analysis to compare the efficacy and safety of available biologic treatments for moderate to severe paediatric plaque psoriasis. METHODS: Releva…

BACKGROUND: HIV transmission and disease progression may be driven by associations HIV risk behaviors have with a constellation of alcohol, other substance, and mood-related conditions (CASM). However, observational study-based measures of these associations are often prone to unmeasured confounding. While meta-analysi…

BACKGROUND: There is currently no recommendation regarding preferred drugs for active eosinophilic oesophagitis (EoE) because their relative efficacy is unclear. We conducted an up-to-date network meta-analysis to compare proton pump inhibitors, off-label and EoE-specific topical steroids, and biologics in EoE. METHOD…

BACKGROUND: Non-pharmacological interventions (NPIs) have been shown to be effective in reducing fatigue, depression, and improving quality of life (QoL) in patients with lung cancer. However, given the diversity of NPIs, the most effective intervention remains to be confirmed. OBJECTIVES: To compare the efficacy of d…

OBJECTIVE: Post-stroke depression (PSD) is a common complication following stroke and is associated with increased mortality risk. Evidence suggests that exercise has a beneficial effect on depression. However, the optimal modality and dose of exercise interventions remain unclear. Therefore, this study aims to explore…

The relationship between exercise and anxiety has been extensively examined over the last 15 years. Three separate meta-analysis were conducted to quantitatively review the exercise-anxiety literature for state anxiety, trait anxiety and psychophysiological correlates of anxiety. Such a procedure allows tendencies of t…