Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 5,441–5,460 · 2627 ms
Raich W A, Rickels K, Raab E·Current therapeutic research, clinical and experimental
Abstract not available
Bergh N P, Dottori O, Löf B A, +2 more·Acta anaesthesiologica Scandinavica. Supplementum
Abstract not available
Kurland A A, Richardson J H·Psychopharmacologia
Abstract not available
Virieux C, Delachaux A·Praxis
Abstract not available
Gerner E W, Meyskens F L, Goldschmid S, +2 more·Amino acids
Polyamine metabolic genes are downstream targets of several genes commonly mutated in colon adenomas and cancers. Inhibitors of ornithine decarboxylase, such as difluoromethylornithine (DFMO), and agents that stimulate polyamine acetylation and export, such as non-steroidal anti-inflammatory drugs (NSAIDS), act at leas…
Koonings P P, Moyer D L, Grimes D A·Obstetrics and gynecology
Recent publications have suggested that use of the Pipelle endometrial suction curette is a safe and effective method by which to obtain samples of endometrial tissue. To address this issue, we performed a randomized clinical trial comparing the Pipelle to the Tis-u-trap in 156 patients. The Pipelle was as effective as…
Sand B B, Marner K, Norn M S·Acta ophthalmologica
The effect of sodium hyaluronate eye drops in the treatment of severe keratoconjunctivitis sicca (KCS) was evaluated in a double masked crossover trial, comparing the effect of a 0.1% solution, a 0.2% solution and placebo in 20 patients. We found significantly decreased rose bengal staining and increased break-up time…
Kinch A P, Taylor H, Warltier R, +2 more·American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
A clinical trial was conducted to compare bond failure when 15-second or 60-second acid etch times were used for the direct bonding of metal edgewise brackets. Bonds totaling 1174 were studied over a period of 6 to 13 months. Analysis of failure rate, bond survival time, and cement remaining after failure showed no sta…
Allegra J C, Bertino J, Bonomi P, +7 more·Seminars in oncology
Hormonal therapy is very effective in the treatment of patients with metastatic breast cancer. Response to various therapies leads to improved quality of life and prolonged survival. This clinical trial compared two commonly utilized additive hormonal agents, tamoxifen citrate and megestrol acetate (Megace). Preliminar…
Fine P D·The Journal of hospital infection
A trial was made comparing the effects of efficient and thorough removal of plaque and debris alone, and with a daily antiseptic mouthwash. The results showed considerable variation but no significant difference in gingival inflammation between hygienic treatment and a daily mouthwash with chlorhexidine-gluconate or po…
Pandhi P, Aslam S, Sharma B K, +2 more·International journal of clinical pharmacology, therapy, and toxicology
The efficacy and safety of labetalol was compared in a double-blind crossover design with propranolol in 27 patients suffering from essential hypertension with a supine diastolic blood pressure of more than 100 mm Hg. Twelve patients completed the trial. Both the drugs significantly reduced the blood pressure as compar…
Wethington J F·Clinical therapeutics
Forty-four patients with sore throat participated in a placebo-controlled, double-blind clinical trial of benzydamine hydrochloride administered as a gargle. After medical evaluation and throat culture, 21 patients were treated with a solution containing benzydamine and 23 patients with a placebo solution. Statistical…
Steardo L, Leo A, Marano E·European neurology
Baclofen (beta-4-chlorophenyl-gamma-aminobutyric acid) shows analgesic properties in rats and resembles carbamazepine and phenytoin in its effects on the spinal trigeminal nucleus of cats. We have, therefore, conducted a clinical trial in 25 subjects, 16 suffering from trigeminal neuralgia, and 9 patients were affected…
Rounsaville B J, Klerman G L, Weissman M M·Archives of general psychiatry
Although pharmacotherapy and psychotherapy are frequently used in combination as treatment for depression, speculations about possible negative interactions of the two treatments remain. This occurs despite growing research evidence demonstrating the greater efficacy of combined treatment. In this report six hypotheses…
El Hennawi M·The British journal of ophthalmology
An open assessment study was carried out during the summer of 1972 in which 2% sodium cromoglycate eyedrops were evaluated in the treatment of patients with vernal keratoconjunctivitis. A highly significant number of patients found the eyedrops effective, while a marked improvement was recorded in mild and moderate cas…
Abengowe C U·The Journal of international medical research
A randomized clinical trial in sixty-two adult patients suffering from typhoid fever, proved by blood and marrow culture, showed that amoxycillin in a dosage schedule of 1 g 8-hourly orally for fourteen days was better than chloramphenicol with regard to clinical and temperature response and in respect of carriers and…
O'Connor T P, Labandter H P, Hiles R W, +1 more·British journal of plastic surgery
A preliminary analysis of a controlled trial of BCG immunotherapy as an adjunct to surgery in the treatment of primary malignant melanoma has been carried out. The length of follow-up varied from 5 years to 6 months. No obvious benefit from BCG immunotherapy has been found so far. On the other hand the treatment is pai…
Woggon B·International pharmacopsychiatry
During an open clinical trial, 51 schizophrenic patients were treated with Penfluirdol, 34 for 1 year and 17 for a shorter time. The mean dosage of Penfluirdol was 22 up to 28 mg per week. Assessments were made on days 0, 14, 28, 56, 90, 180, 270, and 365 using the AMP system and the EPRS scale of Simpson and Angus. Th…
Frith C D, Johnston E C, Joseph M H, +2 more·Journal of neurology, neurosurgery, and psychiatry
5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significa…
Stensrud P, Sjaastad O·Acta neurologica Scandinavica
Propranolol penetrates the blood brain barrier, whereas mainly the racemic form, Inderal, possesses beta-receptor blocking properties. A comparison between d-propranolol and Inderal might therefore indicate the relative importance of the beta blocking properties and possible "central" effects mediated by propranolol an…