44,726 papers found

OBJECTIVE: Circadian rhythm disturbances, like sundowning, are seen in dementia. Because the circadian rhythm is regulated by the biological clock, melatonin might be effective in the treatment of these disturbances. We systematically studied the effect of melatonin treatment in patients with dementia. In addition, we…

Complex regional pain syndrome (CRPS), formerly known as "reflex sympathetic dystrophy," is a chronic neurological disorder characterized by disabling pain, swelling, vasomotor instability, sudomotor abnormality, and impairment of motor function. The disorder usually develops after minor trauma or surgery. No specific…

OBJECTIVE: To map the controlled-trial evidence on photobiomodulation (PBM) for temporomandibular disorders (TMDs), chart the laser dosimetric parameters, quantify reporting completeness, and identify standardization priorities. METHODS: Scoping review per JBI methodology, reported per PRISMA-ScR, and registered on th…

PURPOSE: Primary pulmonary nuclear protein in testis (NUT) carcinoma is a rare, aggressive malignancy driven byrearrangement. AlthoughF-FDG PET/CT is used in clinical management, its imaging features and value have not been systematically evaluated. METHODS: This PRISMA 2020 systematic review was registered with PROSP…

Sepsis-associated coagulopathy (SIC) and disseminated intravascular coagulation (DIC) are major determinants of organ failure and mortality in sepsis. While traditionally viewed as disorders of coagulation and fibrinolysis, emerging evidence highlights the roles of iron metabolism, oxidative stress, and regulated cell…

: Chronic pain represents a major global health burden and significantly impacts quality of life and functional capacity. Physiotherapy plays a central role in its management, yet the rapid growth of research in this field makes it difficult to identify current trends and emerging directions. The aim of this study was…

INTRODUCTION: Heatstroke is a life-threatening condition defined by a core body temperature exceeding 40° C and central nervous system dysfunction. Its onset is potentiated by high heat and humidity, especially if superimposed upon high thermal loads due to exertion or to impaired ability to sweat as associated wi…

Probiotics and postbiotics are essential components of modern dietary supplements, recognized for their beneficial effects on human health. While probiotics positively influence gut microbiota, digestion, and immune responses, their safety remains a concern, particularly in immunocompromised individuals, due to risks s…

INTRODUCTION: Tinnitus is the perception of sound without an external source. Various treatments and therapeutic strategies for tinnitus have been used. More recently, this includes music therapy (MT), which aims to mask tinnitus using specific musical elements such as rhythm, melody, harmony, and tempo. OBJECTIVE: To…

: This study's primary goals are to evaluate the effects of physical therapy on motor delays in children with Down Syndrome, identify the most successful interventions, look at current trends in the field, and suggest future directions for clinical and research development by reviewing the scientific literature publish…

The endoplasmic reticulum (ER) is a central hub of cellular proteostasis, coordinating protein folding, lipid metabolism, calcium signaling, and inter-organelle communication. Disruptions in ER function activate the unfolded protein response (UPR), an evolutionarily conserved signaling network mediated by PERK, IRE1&#x…

OBJECTIVE: This systematic review aimed to synthesize and critically appraise human studies on coding and non-coding RNA expression in cumulus cells (CCs) from women with Polycystic Ovary Syndrome (PCOS), to map consistently dysregulated pathways, evaluate links to oocyte competence, and identify key methodological lim…

BACKGROUND: Temporomandibular disorders (TMDs) and chronic orofacial pain are multifactorial conditions influenced by complex neurobiological and systemic mechanisms. Recent findings emphasise the gut-brain axis as a central modulator of pain, neuroinflammation, and immune signalling. Nevertheless, the role of the gut…

Rheumatologic disorders affecting the central nervous system (CNS) can cause significant neurological and psychiatric morbidity. Early detection of CNS involvement is essential to prevent irreversible damage. This study aims to systematically review cerebrospinal fluid (CSF) autoantibody profiles in rheumatologic disor…

Obstructive sleep apnea (OSA) and olfactory dysfunction have a reciprocal relationship, where each condition exacerbates the other. This review aims to systematically explore the key mechanisms underlying the association between OSA and olfactory impairment, offering a detailed analysis of these interrelated phenomena.…

BACKGROUND: Neuropsychiatric toxicity is a common adverse effect of antibiotics. Advanced age, renal insufficiency, high drug doses, and prolonged therapy are relevant risk factors, suggesting that this event might be caused due to the accumulation of antibiotics in the central nervous system. In this review, the autho…

OBJECTIVE: Although SARS-CoV-2 primarily targets the respiratory system, there is evidence that it can also infect the central nervous system, especially in children, leading to neurological symptoms and long-term consequences. It is imperative to summarize the possible mechanisms, main symptoms, and treatments of neur…

INTRODUCTION: Experimental evidence supports the hypothesis of reciprocal influence between neural systems involved in cognition and central pain processing circuits. Furthermore, studies have demonstrated bidirectional communication between central pain processing areas and the immune system, leading to changes in beh…

Long-term stability and recurrent ptosis are among the most debated topics in endoscopic brow lifts. Although there are many publications on endoscopic brow lifts, more research is needed on long-term brow elevation and stability. In this systematic review we aimed to evaluate the amount of elevation and stability achi…

PURPOSE: To assess the effectiveness of applying digital health palliative care to improve symptoms, mood, and quality of life in patients with advanced cancer. METHODS: We searched PubMed, Embase, Web of Science, Cochrane Library (CENTRAL), and CINAHL databases on November 16, 2023, to identify randomized controlled…