42,458 papers found

INTRODUCTION: Numerous articles have examined the pattern of traumatic deaths. Most of these studies have aimed to improve trauma care and raise awareness of avoidable complications. The aim of the present review is to evaluate whether the distribution of complications and mortality has changed. MATERIALS AND METHODS:…

Complex regional pain syndrome (CRPS), formerly known as "reflex sympathetic dystrophy," is a chronic neurological disorder characterized by disabling pain, swelling, vasomotor instability, sudomotor abnormality, and impairment of motor function. The disorder usually develops after minor trauma or surgery. No specific…

With increasing life expectancy, the quest for skin rejuvenation has gained prominence among individuals of diverse age groups. The popularity of nutricosmetics, notably dietary supplements, has garnered significant attention in recent years. Many scientific investigations have amassed compelling evidence highlighting…

Chikungunya virus (CHIKV) is vectored byandmosquitoes and is found throughout tropical and sub-tropical regions. While most infections cause mild symptoms such as fever and arthralgia, there have been cases in which cardiac involvement has been reported. In adults, case reports include symptoms ranging from tachycardia…

BACKGROUND:: The concept 'encounter' occurs in caring literature as a synonym for dialogue and relation describing deeper levels of interaction between patient and nurse. In nursing and caring research, the concept 'caring encounter' is often used without further reflection on the meaning of the concept. Encounters are…

INTRODUCTION: Heatstroke is a life-threatening condition defined by a core body temperature exceeding 40° C and central nervous system dysfunction. Its onset is potentiated by high heat and humidity, especially if superimposed upon high thermal loads due to exertion or to impaired ability to sweat as associated wi…

Probiotics and postbiotics are essential components of modern dietary supplements, recognized for their beneficial effects on human health. While probiotics positively influence gut microbiota, digestion, and immune responses, their safety remains a concern, particularly in immunocompromised individuals, due to risks s…

INTRODUCTION: Tinnitus is the perception of sound without an external source. Various treatments and therapeutic strategies for tinnitus have been used. More recently, this includes music therapy (MT), which aims to mask tinnitus using specific musical elements such as rhythm, melody, harmony, and tempo. OBJECTIVE: To…

: This study's primary goals are to evaluate the effects of physical therapy on motor delays in children with Down Syndrome, identify the most successful interventions, look at current trends in the field, and suggest future directions for clinical and research development by reviewing the scientific literature publish…

The endoplasmic reticulum (ER) is a central hub of cellular proteostasis, coordinating protein folding, lipid metabolism, calcium signaling, and inter-organelle communication. Disruptions in ER function activate the unfolded protein response (UPR), an evolutionarily conserved signaling network mediated by PERK, IRE1&#x…

OBJECTIVE: This systematic review aimed to synthesize and critically appraise human studies on coding and non-coding RNA expression in cumulus cells (CCs) from women with Polycystic Ovary Syndrome (PCOS), to map consistently dysregulated pathways, evaluate links to oocyte competence, and identify key methodological lim…

BACKGROUND: Temporomandibular disorders (TMDs) and chronic orofacial pain are multifactorial conditions influenced by complex neurobiological and systemic mechanisms. Recent findings emphasise the gut-brain axis as a central modulator of pain, neuroinflammation, and immune signalling. Nevertheless, the role of the gut…

Rheumatologic disorders affecting the central nervous system (CNS) can cause significant neurological and psychiatric morbidity. Early detection of CNS involvement is essential to prevent irreversible damage. This study aims to systematically review cerebrospinal fluid (CSF) autoantibody profiles in rheumatologic disor…

Obstructive sleep apnea (OSA) and olfactory dysfunction have a reciprocal relationship, where each condition exacerbates the other. This review aims to systematically explore the key mechanisms underlying the association between OSA and olfactory impairment, offering a detailed analysis of these interrelated phenomena.…

OBJECTIVE: The objective of this systematic review is to explore the experiences of help-seeking among adolescents with depression, with a specific focus on understanding the experiences and exploring the facilitators and barriers to seeking help for depression. INTRODUCTION: Depression is recognized as a serious ment…

BACKGROUND: Neuropsychiatric toxicity is a common adverse effect of antibiotics. Advanced age, renal insufficiency, high drug doses, and prolonged therapy are relevant risk factors, suggesting that this event might be caused due to the accumulation of antibiotics in the central nervous system. In this review, the autho…

OBJECTIVE: Although SARS-CoV-2 primarily targets the respiratory system, there is evidence that it can also infect the central nervous system, especially in children, leading to neurological symptoms and long-term consequences. It is imperative to summarize the possible mechanisms, main symptoms, and treatments of neur…

INTRODUCTION: Experimental evidence supports the hypothesis of reciprocal influence between neural systems involved in cognition and central pain processing circuits. Furthermore, studies have demonstrated bidirectional communication between central pain processing areas and the immune system, leading to changes in beh…

PURPOSE OF REVIEW: Baclofen, a muscle relaxant that reduces the release of excitatory neurotransmitters in the pre-synaptic neurons stimulating inhibitory neuronal signals in post-synaptic neurons, has been around for over 5 decades. Baclofen is used primarily for spasticity and since 1982, has had a role as an intrath…

Long-term stability and recurrent ptosis are among the most debated topics in endoscopic brow lifts. Although there are many publications on endoscopic brow lifts, more research is needed on long-term brow elevation and stability. In this systematic review we aimed to evaluate the amount of elevation and stability achi…