44,715 papers found

: Endometriosis and lipedema are chronic female-predominant disorders characterized by persistent pain that is frequently disproportionate to anatomical lesion burden. Although traditionally interpreted within distinct lesion-centered frameworks, both conditions exhibit striking clinical and epidemiological parallels,…

BACKGROUND: Chronic central serous chorioretinopathy (cCSC) can lead to irreversible visual impairment. Traditional treatment methods are limited by their efficacy and the risk of complications. Subthreshold micropulse laser (SML) therapy has emerged as a promising treatment option. OBJECTIVE: This study systematicall…

: The central vein sign (CVS) is a radiological feature proposed as a multiple sclerosis (MS) imaging biomarker able to accurately differentiate MS from other white matter diseases of the central nervous system. In this work, we evaluated the pooled proportion of the CVS in brain MS lesions and to estimate the diagnost…

PURPOSE: To identify the most effective dressing for covering long-term central venous catheter exit site to prevent catheter-related infections and skin irritation in patients undergoing hematopoietic stem cell transplantation. METHODS: Systematic Review. The search was performed in the following electronic databases…

BACKGROUND: The lack of a standard treatment approach has contributed to poor outcomes of patients with recurrent central nervous system (CNS) mixed malignant germ cell tumors (MMGCT). There are no data in the literature supporting optimal re-induction chemotherapy regimens that should be used for patients with recurre…

BACKGROUND: HIV and tuberculosis (TB) co-infection poses a significant health challenge, particularly when involving the central nervous system (CNS), where it leads to severe morbidity and mortality. Current treatments face challenges such as drug resistance, immune reconstitution inflammatory syndrome (IRIS), and per…

The term "pharmacovigilance" defines the activities related to the collection, detection, assessment, monitoring, and prevention of adverse reactions occurring with medications. Recently, the spectrum of "-vigilance" has broadened to include safety of herbal products and cosmetic products as well. "Cosmetovigilance" wa…

The scope of the article is to review the different approaches that have been used for HIV vaccines. The review is based on articles retrieved by PubMed and clinical trials from 1990 up to date. The article discusses virus complexity, protective and non-protective immune responses against the virus, and the most import…

Symptomatic epigastric hernia is rare in pregnant women. A case history, management of which prompted a systematic review of the literature and proposed plan for treatment of such cases, is hereby presented. There is paucity of information on management of this condition in the standard literature as searches in Pubmed…

INTRODUCTION: A proportion of patients hospitalised for COVID-19 acquire the disease during their hospital stay, underscoring the risk of hospital-acquired COVID-19 (HA-COVID-19). This risk is presumed to be high, given how commonly and intensely air and surfaces within hospitals are reportedly contaminated with SARS-C…

BACKGROUND: Stroke is a leading cause of disability, with upper limb dysfunction affecting the majority of survivors. Non-immersive virtual reality (NIVR) has emerged as an accessible and engaging adjunctive therapy that may address the limitations of conventional rehabilitation and promote motor recovery. METHODS: Th…

BACKGROUND: Glioblastoma (GBM) is a highly aggressive, invasive, and growth factor-independent grade IV glioma. Survival following the diagnosis is generally poor, with a median survival of approximately 15 months, and it is considered the most aggressive and lethal central nervous system tumor. Conventional treatments…

BACKGROUND: Artificial intelligence (AI), conceived in the 1950s, has permeated numerous industries, intensifying in tandem with advancements in computing power. Despite the widespread adoption of AI, its integration into medicine trails other sectors. However, medical AI research has experienced substantial growth, at…

OBJECTIVE: To evaluate the pooled prevalence and identify risk factors of congenital anomalies among neonates in Africa. METHODS: The pooled birth prevalence of congenital anomalies was the first outcome of this review, and the pooled measure of association between congenital anomalies and related risk factors in Afri…

BACKGROUND: Standard diagnostic and monitoring methods for glycemic status involve invasive sample collection through venous puncture or fingerstick. Recent attention has been focused on exploring noninvasive methods through oral biofluids. Specifically, serum fructosamine has been established as a short-term (2- to 3-…

BACKGROUND: Central nervous system (CNS) injury remains a severe neurological condition with limited regenerative capacity. NG2-glia are abundant and functionally versatile glial cells that have attracted increasing attention in CNS repair research. However, their roles are complex and context-dependent, ranging from e…

INTRODUCTION: Tension-Type Headaches (TTH), particularly in its chronic form, constitutes a persistent pain syndrome that can substantially impair physical, cognitive, emotional, and social functioning. Although this is the most common type of headache, there is a lack of clear consensus on the optimal long-term treatm…

OBJECTIVES: To provide a narrative overview of popliteal artery injury (PAI) associated with orthopedic knee surgery, focusing on its mechanisms, risk factors, diagnostic challenges, treatment strategies, and medico-legal appraisal within the Italian civil healthcare liability framework. METHODS: A non-systematic lite…

UNLABELLED: The number of older adults worldwide has increased significantly, and by 2030 one in six people will be aged 60 years or older. Population aging is a central issue in global health agendas. The Decade of Healthy Ageing (2021-2030) aims to improve the quality of life of older adults. OBJECTIVE: To identify…

Food additives are consumed as mixtures in ultra-processed foods, but their independent contribution to glucose dysregulation is difficult to separate from diet quality and food matrix. PubMed/MEDLINE, Embase, Web of Science Core Collection, Scopus, and CENTRAL were searched from inception to 30 April 2026, followed by…