44,715 papers found

: Non-contact anterior cruciate ligament (ACL) injury is common and disabling, often requiring reconstruction and predisposing individuals to early post-traumatic osteoarthritis, making scalable, exercise-based prevention a clinical and public health priority. Excessive peak vertical ground reaction force (vGRF) during…

BACKGROUND: Lung transplantation (LTx) is performed in approximately 4500 patients worldwide each year. Postoperatively, patients are at high risk of muscle catabolism due to Intensive Care Unit (ICU)-acquired weakness, potentially compromising functional recovery. While post-LTx rehabilitation is usually initiated aft…

BACKGROUND: Workplace learning is essential for preparing undergraduate nursing students for complex healthcare environments. Despite its central role in developing competence and professional identity, the theoretical foundations of workplace curricula remain poorly articulated. A clearer understanding of how theory i…

INTRODUCTION: Huntington disease (HD) is a progressive neurodegenerative disorder caused by CAG repeat expansion in the HTT gene. It typically presents with choreiform movements, cognitive decline, and executive dysfunction. Moreover, psychiatric symptoms such as depression, psychosis, and disinhibition are common. Cat…

BACKGROUND: Extended reality (XR) simulation offers repeatable, risk-free practice for ophthalmic training. We conducted a systematic review and meta-analysis to quantify its effects on training outcomes. METHODS: We searched MEDLINE (PubMed), Embase, Web of Science Core Collection, and Cochrane CENTRAL from inception…

Dysphagia and aspiration are common complications in tracheostomized critically ill patients. The Modified Evan's Blue Dye Test (MEBDT) is a non-invasive, bedside, adjunctive rule-in signal for aspiration when positive. However, its diagnostic accuracy compared to the gold standard Fiberoptic Endoscopic Evaluation of S…

PURPOSE: This study aimed to evaluate the clinical impact of preoperative carbohydrate loading in elective colorectal surgery. METHODS: The review followed the Cochrane Handbook for Systematic Reviews of Interventions and PRISMA guidelines. A systematic search was conducted in MEDLINE (via PubMed), Scopus and Cochrane…

BACKGROUND: Radiofrequency microneedling (RFMN) is a prominent minimally invasive treatment for facial rejuvenation. While individual studies report positive outcomes, a comprehensive synthesis of evidence across efficacy, safety, and patient satisfaction is lacking. OBJECTIVES: To synthesize evidence on the aesthetic…

INTRODUCTION: In medical education research, the transfer of knowledge depends heavily on the visibility of scientific publications. Whether Open Access (OA) actually increases this visibility through a citation advantage (Open Access Citation Advantage, OACA) is still unclear for the field of medical education. This s…

OBJECTIVES: To synthesise evidence on prognosis, functional outcomes, and prognostic factors across functional neurological disorder (FND) subtypes and age groups. DESIGN: Systematic review with structured narrative synthesis (PRISMA 2020). DATA SOURCES: MEDLINE (PubMed), Embase, PsycINFO, CINAHL, CENTRAL, Web of Sci…

BACKGROUND: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor, associated with an exceedingly poor prognosis. The gut microbiota, a complex community of microorganisms, critically regulates host physiological homeostasis and communicates bidirectionally with the central nervous system v…

BACKGROUND: Self-regulation is central to adolescent emotional and cognitive development, and deficits in self-regulation may associate with depression and anxiety. This scoping review maps the use of the Emotional Go/No-Go (EGNG), Delay Discounting Task (DDT), and Balloon Analogue Risk Task and Youth version (BART) in…

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects joints and causes mobility problems. RA is associated with high mortality and morbidity as a result of the increased prevalence of cardiovascular disease (CVD) and cardiovascular (CV) risk factors, such as blood pressure (BP),…

BACKGROUND: Kangaroo mother care (KMC) is an effective care practice for preterm infants, based on early and continuous skin-to-skin contact between mother and newborn, with benefits on physiological stability, reduction of mortality, and promotion of lactation. However, the optimal timing for early initiation of KMC i…

AIM: This review systematically evaluated the impact of enzyme replacement therapy (ERT) on audiological outcomes in Fabry disease, focusing on the nature of audiological findings, therapeutic effects on hearing function, and factors influencing treatment response. METHOD: The systematic review was conducted following…

INTRODUCTION: To address the high prevalence and significant burden of overweight and obesity, surveillance through sentinel networks should be considered. The aim of this review is to identify the sentinel surveillance networks in relation to overweight and obesity and to describe their characteristics and methodology…

BACKGROUND: Perioperative hypoparathyroidism (hypoPT) represents a prevalent complication of thyroid surgery. Reported risk factors remain inconsistent, and identical factors may exert different effects depending on whether hypoPT is defined by serum calcium concentration or parathyroid hormone (PTH) levels. A comprehe…

PURPOSE: Multiple, nonharmonised classification systems exist for posterior medial meniscus root tears (PMMRT), yet their diagnostic accuracy and observer reliability remain unclear. This PRISMA-2020 systematic review aimed to catalogue available PMMRT classifications and to summarise accuracy and reliability metrics.…

Central nervous system (CNS) tumors are the most common solid tumors in pediatric patients and the leading cause of childhood cancer-related mortality. Their rarity compared to adult cancers has made enrolling sufficient cases for clinical trials challenging. Consequently, pediatric CNS tumors were long treated with ad…

BACKGROUND: Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive memory degradation and language and behavior disorders. Apart from curative pharmacological therapies, music therapy (MT) has been diffusely used as an efficient and economical non-pharmacological t…