42,458 papers found

BACKGROUND: Under the background that diffusion kurtosis imaging (DKI) has become a research hotspot of central nervous system diseases, there are no studies with large sample size evaluating the value of DKI in diagnosing Parkinson's disease (PD). Moreover, the diagnostic efficacy of DKI in PD is not consistent. There…

BACKGROUND: Rapid sequence intubation (RSI) is a crucial step in the resuscitation process for critically ill patients, and the judicious use of sedative drugs during RSI significantly influences the clinical outcomes of patients. Ketamine is a commonly used anesthetic sedative; however, its impact on the mortality of…

INTRODUCTION: Obesity is a global public health concern that is now on the rise, especially in low- and middle-income nations. Despite the fact that there are several studies reporting the prevalence of central obesity among adults in Ethiopia, there is a lack of a systematic review and meta-analysis synthesizing the e…

BACKGROUND: Hormone therapy is widely used for contraception, disease treatment, and as hormone replacement therapy in women. Many studies have attempted to establish the relationship between the use of exogenous hormones and the development of CNS tumors; however, the results remain inconclusive. OBJECTIVES: The objec…

UNLABELLED: Central nervous system disorders represent a major global cause of mortality and disability, with limited effective treatments available. Traditional Chinese Medicine theory posits a close link between kidney and brain function. Curculigoside, the primary bioactive phenolic glycoside and chemical marker of…

BACKGROUND: Central venous catheters (CVCs) are widely used in pediatric care; however, their indwelling procedure can lead to severe complications such as catheter-associated infections and thrombosis. These complications significantly increase the suffering of pediatric patients, prolong hospitalization, and pose lif…

BACKGROUND: Despite the ongoing discussion around complete mesocolic excision (CME) during right colectomy, it remains a poorly defined concept, and its oncologic role in the treatment of right-sided colon cancer remains unclear. Since its original description, CME has been interpreted inconsistently, with multiple tec…

Fibromyalgia (FM) syndrome is characterised by constant and pervasive musculoskeletal pain and may be comorbid with obesity. Glucagon Peptide-1 Receptor Agonists (GLP-1RAs) are relatively new pharmacotherapies developed for the treatment of type 2 diabetes mellitus (T2DM) and have been repurposed for the treatment of o…

BACKGROUND: Interspinous process devices (IPDs) have been widely promoted as a minimally invasive alternative to traditional decompressive surgery for lumbar spinal stenosis (LSS). However, their clinical durability, safety, and comparative effectiveness have remained controversial. This review aims to review and synth…

OBJECTIVE: Candida auris (C. auris) is a multidrug-resistant yeast capable of causing invasive infections in both immunocompromised and immunocompetent hosts. While bloodstream and wound infections are well described, central nervous system (CNS) involvement remains rare and poorly characterized. We present a case of C…

OBJECTIVES: Eosinophilic granulomatosis with polyangiitis (EGPA) involves systemic inflammation of small to medium vessels, with central nervous system (CNS) involvement being rare. While CT (computed tomography) and MRI (magnetic resonance imaging) are standard for diagnosing CNS involvement, digital subtraction angio…

INTRODUCTION: The best management strategy still remains strong controversy for acute nonarteritic central retinal artery occlusion (CRAO). We thus performed a meta-analysis to determine the efficacy of intra-arterial thrombolysis (IAT) for visual improvement according to different times from symptom onset. METHODS: W…

PURPOSE: To review retinal vein occlusion (RVO) and its relationship with retinal oxygen saturation via automated retinal oximetry in eyes with RVO. METHODS: A literature review was performed in PubMed and Medline until October 2021 utilizing specific keywords and cross-matched reference lists. RESULTS: This review f…

BACKGROUND: Complete mesocolic excision (CME) for colonic cancer offers a surgical specimen of higher quality, with higher number of lymph nodes compared to conventional colectomy. However, evidence on oncological outcomes is limited. The aim of the present study is to review recent literature and provide more informat…

AIMS: To examine the rates of hamstring graft salvage with arthroscopic debridement of infected anterior cruciate ligament (ACL) reconstruction as reported in the literature and discuss functional outcomes. MATERIALS AND METHODS: A search was performed without language restriction on PubMed, EMBASE, Ovid, CINAHL and C…

BACKGROUND: The aim of this study was to assess the impact on quality of life from informing patients with cancer of their diagnosis and disease status. METHOD: We searched the follow databases, PubMed, CENTRAL (Cochrane Central Register of Controlled Trials), PsycINFO, WEB OF SCIENCE, Embase, CBM (Chinese Biomedical…

PURPOSE: This study aims to provide a systematic review and meta-analysis of Pulse Indicator Continuous Cardiac Output (PICCO) compared with conventional central venous pressure (CVP) monitoring in the treatment of traumatic shock. METHODS: A systematic literature retrieval was conducted in databases including PubMed,…

BACKGROUND: Catheter associated bloodstream infections (CLABSI) are the most frequently reported healthcare-associated infections in pediatric intensive care units (PICUs). Largely preventable, CLABSI have prompted the global implementation of care bundles aimed at reducing infection rates, healthcare costs, length of…

: Nailfold videocapillaroscopy (NVC) is a non-invasive method for visualizing systemic micro-circulation, primarily used in rheumatology. Many ocular diseases (e.g., glaucoma, diabetic retinopathy (DR), and central serous chorioretinopathy (CSC)) involve microvascular disturbances. Since microangiopathies are often sys…

BACKGROUND AND OBJECTIVE: Tracheal stenosis is a potentially life-threatening condition whose symptoms including dyspnea, wheezing and cough, are frequently misdiagnosed, leading to a delay in the diagnosis. The more frequent causes of stenosis are iatrogenic: prolonged intubation (producing a circumferential ischemic…