5,011,235 papers found

Helicobacter pylori is a recognized cause of a variety of gastroduodenal pathology. The high prevalence of both H pylori infection and related diseases within the community warrants its consideration as a public health care issue. The availability of reliable and safe noninvasive diagnostic techniques coupled with the…

Although hemovigilance is not a word used commonly in the United States, the concept of monitoring morbidity associated with blood transfusion is accepted widely. Currently, quality management focuses on error avoidance rather than error detection in both the "manufacturing" and "clinical" aspects of blood banking. "Ma…

BACKGROUND: Mental health problems contribute significantly to the overall disease burden worldwide and are major causes of disability, suicide, and ischaemic heart disease. People with bipolar disorder report lower levels of physical activity than the general population, and are at greater risk of chronic health condi…

BACKGROUND: Heavy menstrual bleeding (HMB) is excessive menstrual blood loss that interferes with women's quality of life, regardless of the absolute amount of bleeding. It is a very common condition in women of reproductive age, affecting 2 to 5 of every 10 women. Diverse treatments, either medical (hormonal or non-ho…

Immune-mediated rheumatologic and musculoskeletal diseases (RMDs) comprise a heterogeneous group of systemic conditions that affect the connective tissues of the musculoskeletal system and internal organs. Immune-mediated RMDs are driven by chronic autoimmune responses and typically require continuous or repeated admin…

BACKGROUND: A EULAR taskforce was convened to develop recommendations for lifestyle behaviours in rheumatic and musculoskeletal diseases (RMDs). The aim of this paper was to review the literature on the relationship between smoking and alcohol consumption with regard to RMD-specific outcomes. METHODS: Two systematic r…

IMPORTANCE: Breast cancer is a leading cause of premature mortality among US women. Early detection has been shown to be associated with reduced breast cancer morbidity and mortality. OBJECTIVE: To update the American Cancer Society (ACS) 2003 breast cancer screening guideline for women at average risk for breast canc…

IMPORTANCE: The protocol of a randomized trial is the foundation for study planning, conduct, reporting, and external review. However, trial protocols vary in their completeness and often do not address key elements of design and conduct. The SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) s…

Vitamin D deficiency is common in patients with chronic kidney disease (CKD) and associates with poor outcomes. Current clinical practice guidelines recommend supplementation with nutritional vitamin D as for the general population. However, recent large-scale clinical trials in the general population failed to demonst…

OBJECTIVES: To update the EULAR points to consider (PtCs) on the use of immunomodulatory therapies in COVID-19. METHODS: According to the EULAR standardised operating procedures, a systematic literature review up to 14 July 2021 was conducted and followed by a consensus meeting of an international multidisciplinary ta…

The incidence of coronary artery disease (CAD) has dramatically increased in India during the recent years. There are two facets of CAD: stable CAD and unstable CAD which includes patients with acute coronary syndrome (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction). The tre…

Despite major advancements in liver transplantation, graft dysfunction remains a key challenge for long-term success. The use of extended criteria donors, including donation after circulatory death, grafts with prolonged warm ischemia, steatotic grafts, and older donors, is often associated with delayed function or pri…

Advanced practice providers (APPs), including nurse practitioners (NPs) and physician assistants (PAs), play a vital role in emergency medicine (EM), addressing workforce shortages and enhancing patient care. Despite their growing presence, position statements from the American College of Emergency Physicians (ACEP) an…

BACKGROUND: Two vaccines have been licensed to prevent chikungunya, a live attenuated vaccine (IXCHIQ) manufactured by Valneva and a virus-like particle chikungunya vaccine (VIMKUNYA) manufactured by Bavarian Nordic. One or both vaccines are now available in many countries globally, including Brazil, Canada, United Kin…

The International Liaison Committee on Resuscitation conducts continuous reviews of new, peer-reviewed, published cardiopulmonary resuscitation science and publishes more comprehensive reviews every 5 years. The Education, Implementation, and Teams chapter of thedescribes all published resuscitation evidence reviewed b…

INTRODUCTION: Neurosonology is a medical discipline that utilizes ultrasound techniques to study the nervous system, with its applications progressively increasing. The indications and methodology for applying these techniques in patients with headaches are not well defined, thus there is a need for a consensus guideli…

Chronic kidney disease (CKD) is a common clinical condition with significant health risks for patients and is widely recognised as a major public health concern. Laboratory medicine plays a crucial role in both diagnosing and managing CKD, as diagnosis and staging rely on estimated glomerular filtration rate (GFR) and…

BACKGROUND: This overview of systematic reviews (SRs) and meta-analysis (MAs) aimed to systematically collate, appraise and synthesize evidence of probiotics for functional constipation (FC) in children. METHODS: SRs/MAs of probiotics for FC in children were systematic identified by searching Cochrane Library, PubMed,…

OBJECTIVES: Working Group 5 was convened to discuss and find consensus on the topics of implant placement and loading protocols associated with single missing teeth in the anterior maxilla (aesthetic zone). Consensus statements, clinical recommendations, patient perspectives and future research suggestions were develop…

UNLABELLED: High blood pressure causes 45% of deaths from heart diseases and 51% of deaths from stroke. OBJECTIVE: To conduct systematic search and summarize the systematic reviews and/or meta-analyses about impact of isometric training on blood pressure. MATERIAL AND METHODS: Systematic search for publications in Pu…