44,715 papers found

This study is to estimate the diagnostic accuracy of Tokuhashi and Tomita scores that assures 6-month predicting survival regarded as a standard of surgical treatment. We searched PubMed, EMBASE, European PubMed central, and the Cochrane library for papers about the sensitivities and specificities of the Tokuhashi and/…

BACKGROUND: Delayed gastric emptying is a serious complication of pancreaticoduodenectomy. The effect of pylorus removal on delayed gastric emptying has not been well evaluated. STUDY DESIGN: We searched five databases (PubMed, EMBASE and the Cochrane Central Register of Controlled Trials, Scopus and Web of Science) u…

OBJECTIVE: To analyse evidence from randomized controlled trials (RCTs) on the prevention and control of neglected tropical diseases (NTDs) and to identify areas where evidence is lacking. METHODS: The Cochrane Central Register of Controlled Trials and PubMed were searched for RCTs and the Cochrane Database of Systema…

The objective of this systematic review was to estimate the efficacy of protraction facemask on the correction of Class III malocclusion in the short term. A systematic review of articles was performed using different electronic databases (PubMed, Ovid, Cochrane Central Register of Controlled Trials, Web of Science, LI…

OBJECTIVES: To perform a systematic up-to-date review and critical discussion of potential clinical applications of cangrelor based on its pharmacologic properties and the main findings from randomized clinical studies. METHODS: A database search (PubMed, CENTRAL and Google Scholar) by two independent investigators, i…

BACKGROUND: Venous thromboembolism (VTE) is a prevalent disease with potential serious consequences. Idraparinux and idrabiotaparinux are two kinds of long-acting pentasaccharides. Evidence has shown that idraparinux and idrabiotaparinux are effective anticoagulants. However, up to now, there is no consensus on whether…

Combining chemotherapy with preoperative radiotherapy (RT) has a sound radiobiological rationale. We performed a systematic review and meta-analysis of trials comparing preoperative RT with preoperative chemoradiation (CRT) in rectal cancer patients. The Cochrane Central Register of Controlled Trials, Web of Science, E…

OBJECTIVES: To assess how nurse to patient ratios and nurse work hours were associated with patient outcomes in acute care hospitals, factors that influence nurse staffing policies, and nurse staffing strategies that improved patient outcomes. DATA SOURCES: MEDLINE (PubMed), CINAHL, Cochrane Databases, EBSCO research…

Owing to the increasing disparity of organ demand and organ supply the search for optimal immunosuppressive strategies has become a central issue in kidney transplantation (KTX). In the focus today are modifications of the use of calcineurin-inhibitors (CNIs, Cyclosporine A/Tacrolimus) and steroids, as they are nephrot…

Inflammation is a complex biological response involved in the pathophysiology of several chronic diseases. Although conventional anti-inflammatory therapies are effective, their prolonged use can be associated with relevant adverse effects. Although non-steroidal anti-inflammatory drugs and glucocorticoids are widely u…

: Carpal tunnel syndrome is the most common entrapment neuropathy of the upper limb and an important cause of pain, sensory disturbance, and hand dysfunction. Open and endoscopic carpal tunnel release are effective, but they may be associated with scar-related pain, wound complications, and delayed return to work. Ultr…

PURPOSE: Artificial intelligence (AI)-enabled software as a medical device (SaMD) is increasingly used across clinical specialties, but its governance remains difficult because adaptive systems raise ongoing concerns about version control, subgroup performance reporting, and postmarket performance drift. This scoping r…

: Primary splenic pregnancy (PSP) is a rare and life-threatening form of extrauterine pregnancy. Evidence is limited to case reports, and detailed analyses of all aspects of PSP are lacking. The objective is to review and summarize the clinical features, diagnostic methods, management strategies, and maternal outcomes…

OBJECTIVES: This systematic review and meta-analysis aimed to assess the effect of behavioral interventions that include goal setting on pain, disability, and physical activity in people with chronic musculoskeletal pain. METHODS: Five electronic databases (PubMed, CENTRAL [Cochrane Library], PEDro, PsycINFO, and CINA…

Sickle cell disease (SCD) is a chronic inherited disorder characterized by recurrent pain, organ damage, and reduced life expectancy. Beyond its clinical burden, individuals with SCD experience significant stigma that adversely affects psychological well-being, health-related quality of life (HRQoL), and healthcare acc…

Western Canadian and U.S. communities outside urban centres remain underserved by primary, specialist, emergency, mental health, and chronic-disease services. These access problems reflect distance, weather, workforce shortages, specialist maldistribution, primary care attachment gaps, broadband limitations, and the go…

BACKGROUND: Major depressive disorder (MDD) is a global cause of disability, with many patients experiencing suboptimal response to conventional treatments. Mindful breathing exercises, a simple and scalable technique, have emerged as a promising non-pharmacological intervention for alleviating depressive symptoms and…

INTRODUCTION: Non-pharmaceutical interventions (NPIs) such as mask use, physical distancing, business or school closure, and isolation have been central to controlling respiratory viral infections, including influenza, COVID-19, and respiratory syncytial virus (RSV). Understanding the preferences of the public and stak…

BACKGROUND: Infections with liver flukes (,, and.) cause high burden. Mechanistic models have been employed to disentangle their transmission dynamics and guide the design of control strategies. However, no comprehensive review of these mechanistic models has yet been undertaken. METHODS: In this systematic review, we…

BACKGROUND: This systematic review aimed to identify perinatal risk factors associated with obesity in children aged ≤5 years. METHODS: This studyfollowed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline (via PubMed), Embase, and Cochrane CENTRAL were searched from ince…