376,015 papers found

A meta-analysis of the controlled clinical trials comparing the efficacy of combined lithium-imipramine therapy with each drug alone in the prevention of relapse in patients with unipolar depressive illness shows the combination to be superior to lithium alone (for any relapse, p less than 0.05; for specifically depres…

The availability of highly effective ulcer-healing agents has made drug therapy the treatment of choice for the large majority of patients with peptic ulceration. Attention has now shifted from healing to reduction of the very high relapse rates still seen with most drug regimens.

A large number of reports on human protease inhibitor (PI) type frequencies in various populations have now appeared. A combination of the results of published studies shows that the observed frequencies of the M subtype homozygotes and heterozygotes differ significantly from those predicted by the Hardy-Weinberg equil…

BACKGROUND: Intravitreal aflibercept injection for wet age-related macular degeneration (AMD) was initially approved with a regimen consisting of three monthly loading doses followed by maintenance doses every 8 weeks. Alternative regimens with a reduced treatment burden have been explored. The treat-and-extend (TAE) r…

Coordinate-based meta-analyses (CBMA) allow researchers to combine the results from multiple functional magnetic resonance imaging experiments with the goal of obtaining results that are more likely to generalize. However, the interpretation of CBMA findings can be impaired by the file drawer problem, a type of publica…

Point estimation for the selected treatment in a two-stage drop-the-loser trial is not straightforward because a substantial bias can be induced in the standard maximum likelihood estimate (MLE) through the first stage selection process. Research has generally focused on alternative estimation strategies that apply a b…

BACKGROUND: Acupuncture is a clinically recognized treatment for major depressive disorder (MDD), but the associations of efficacy with dosage, treatment course, frequency, acupuncture modality, needle retention time, and manipulation remain unclear. This study evaluated the efficacy and safety of acupuncture for MDD a…

OBJECTIVES: We aimed to assess how often randomized controlled trials (RCTs) in adult cardiac surgery found significant mortality benefits for newer interventions vs older ones, whether observed treatment effect estimates changed over time and whether RCTs and nonrandomized observational studies gave similar results.…

Robotic-assisted partial nephrectomy (RAPN) is the preferred minimally invasive nephron-sparing technique, with outcomes comparable to open and laparoscopic surgery. While most evidence derives from the da Vinci system, newer robotic platforms such as Hugo, Hinotori, KangDuo and MP1000 are emerging. This systematic rev…

BACKGROUND: Antimicrobial dressings have been used to treat diabetic foot ulcers (DFU). However, no direct or indirect comparison among silver dressings, honey dressings or antibiotic-impregnated bone cement (ABC) for DFU has been performed to date. OBJECTIVE: To systematically evaluate the efficacy of the three antim…

BACKGROUND: Colonoscopy effectiveness in detecting colorectal carcinoma depends on adequate bowel preparation (ABP). This network meta-analysis assesses the efficacy and safety of various bowel preparation regimens in patients with constipation. METHODS: PubMed, Cochrane Central and ScienceDirect were searched till Ap…

OBJECTIVES: To explore the association of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on heart rate (HR) in overweight or obese patients without diabetes. METHODS: A comprehensive search of the PubMed, Web of Science, Embase, and Cochrane Library databases was conducted. Mean differences (MDs) were calculated…

A network meta-analysis of randomized controlled trials (RCTs) was conducted to establish the ranking of various bariatric surgeries in mid- and long-term follow-up durations for people with type 2 diabetes mellitus (T2DM), based on T2DM remission, HbA1c levels, and cardiometabolic outcomes. We searched PubMed, Embase,…

AIMS: To ascertain the impact of varying exercise intensities and volumes on clinical outcomes of patients with coronary artery disease (CAD) via a systematic review and meta-analysis. METHODS AND RESULTS: This study included randomized controlled trials to evaluate the effects of different intensity levels and volume…

ObjectiveThis study aimed to compare the effects of different dual-task training modalities on walking and balance in stroke patients using network meta-analysis.Data sourcesRandomized controlled trials were searched in PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and Chine…

BACKGROUND AND OBJECTIVES: Chronic subdural hematoma (cSDH) is a common neurosurgical condition, particularly in elderly patients. Middle meningeal artery embolization (MMAE) has emerged as a promising intervention, while statins have been explored for their anti-inflammatory and angiogenesis-modulating properties. Thi…

PURPOSE: In this study we gathered and analyzed the available evidence regarding 17 different imaging modalities and performed network meta-analysis to find the most effective modality for the differentiation between brain tumor recurrence and post-treatment radiation effects. METHODS: We conducted a comprehensive sys…

BACKGROUND/AIMS: Various expanded criteria (EC) for liver transplantation (LT) in patients with hepatocellular carcinoma (HCC) have been proposed to avoid the narrow nature of the Milan criteria (MC). To investigate which EC predicts more favorable outcomes in terms of overall survival (OS) and recurrence-free survival…

If meta-analysis is to provide valuable answers, then it is critical to ensure clarity about the questions being asked. Here, we distinguish two important questions concerning cognitive bias modification research that are not differentiated in the meta-analysis recently published by Cristea(2015) in this journal: (1) d…