43,306 papers found

Spectacle lens design has evolved from spherical lenses to aspheric lenses (ASL) and freeform lenses (FFL) to improve peripheral optics and wearer comfort. In this review, we compare ASLs and FFLs across optical performance, visual function, patient-reported outcomes, and practical considerations. We synthesized eviden…

BACKGROUND: Acute pain in hospitalized pediatric patients is prevalent. Recent shifts in the paradigm of pediatric acute pain management focus less on reliance on opioids, due to their adverse side effects and risk of dependence, and more on multimodal pain management. OBJECTIVE: We sought to review the most recent st…

BACKGROUND: Vasomotor symptoms are the most common complaints for which menopausal women seek medical care. Eighty per cent of all menopausal women will have hot flushes and night sweats, and of these 9% will have severe symptoms impacting their quality of life. Ideally, treatment should target the group most severely…

PURPOSE: To summarize the state of knowledge on kisspeptin, a factor that alters the migration properties of some types of cancer cell and also plays an important role in the control of the reproductive axis. METHODS: PubMed search, identifying the most recent relevant information. RESULTS: This review describes the…

The objective of the authors is to highlight the historical complexities for the diagnosis and treatment of hypoactive sexual desire disorder (HSDD) with a focus on Flibanserin. A systematic review of the medical literature published in PubMed using the search terms HSDD and Flibanserin was conducted. Each author revie…

Prazosin, a centrally acting α1 adrenoceptor antagonist, has been included in two published algorithms amongst the list of medications that may be used in the management of behavioural and psychological symptoms of dementia (BPSD). However, a review of PubMed, Ovid and Cochrane Collaboration found that there was…

The aim of this review was to characterise the clinical features of basal cell carcinomas (BCCs) occurring on the lips. A review of the literature was performed using PubMed to identify reports of BCCs of the lips. Additionally, a retrospective search of the archives of our diagnostic oral pathology service was perform…

AIMS: Brain injuries based on their causes are divided into two categories, TBI and NTBI. TBI is caused by damages such as head injury, but non-physical injury causes NTBI. Prolactin is one of the blood factors that increase during brain injury. It has been assumed to play a regenerative role in post-injury recovery.…

Stereotactic body radiotherapy (SBRT) enables high-precision, high-dose treatment of liver lesions with acceptable toxicity. With the introduction of flattening filter-free (FFF) beams and the use of different photon energies, there is potential for improved dosimetry and treatment efficiency; however, the optimal sele…

As of April 8, 2016, articles in Neurology® Genetics can be searched using PubMed. Launched in 1996, PubMed is a search engine that accesses citations and abstracts of more than 26 million articles. Its primary sources include the MEDLINE database, which was started in the 1960s, and biomedical and life sciences j…

(JMIS) is the official journal of the Korean Society of Endo-Laparoscopic & Robotic Surgery (formerly the Korean Society of Endoscopic and Laparoscopic Surgeons). The editorial board of JMIS has been trying steadily for several years to be indexed by the international literature databases. As a first step, JMIS has bee…

Major depressive disorder (MDD) and treatment-resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor-level treatment strategies beyond monoamine reuptake. The serotonin 5-HT2B receptor (5-HT2BR) is uniquely positioned at the interface of central-antidepressant mechanisms and…

CONTEXT: Flavones, the key active components in Traditional Chinese Medicine (TCM), have demonstrated antidepressant activity. Given the numerous animal studies conducted, a systematic analysis is essential to provide a valuable reference for future research. OBJECT: This study investigated the antidepressant activity…

INTRODUCTION: Persistent breathlessness is a debilitating symptom that is prevalent in the community, particularly in people with chronic and life-limiting illnesses. Treatment includes different steps, including pharmacological treatment aiming to improve the symptom and optimize people's wellbeing. AREAS COVERED: Pu…

To assess centrally mediated analgesic mechanisms in clinical trials with pain patients, objective standardized methods such as electroencephalography (EEG) has many advantages. The aim of this review is to provide the reader with an overview of present findings in analgesics assessed with spontaneous EEG and evoked br…

OBJECTIVE: Cerebral arteriovenous malformations (AVMs) are vascular lesions whose pathogenesis, although not fully elucidated, is likely multifactorial. Recent research investigating vessel development suggests a potential hierarchical model in which capillary sprouts from higher-flow arteries give rise to lower-flow v…

BACKGROUND: The incidence of colon cancer is increasing in Norway and about 2200 new cases are now diagnosed each year. This paper presents accepted principles of the surgical treatment of the disease. MATERIAL AND METHODS: The article is based on literature retrieved from the PubMed and Cochrane databases, guidelines…

CXCR3 is a well-known receptor involved in immune cell recruitment and inflammation. Pathological inflammation leads to pain stimulation and hence nociception. Therefore, we decided to review the recent research on CXCR3 to identify its precise role in the modulation of pain in a variety of clinical conditions targetin…