Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years.
Vercellati Cristina, Zaninoni Anna, Marcello Anna P, +6 more·British journal of haematology
We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011-2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressiv…