42,457 papers found

BACKGROUND AND AIM: Pancreatitis is the most common and serious complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). Prevention strategies targeting risk factors could be important to reduce the rate of post-ERCP pancreatitis. However, the risk factors for post-ERCP pancreat…

OBJECTIVE: To analyse evidence from randomized controlled trials (RCTs) on the prevention and control of neglected tropical diseases (NTDs) and to identify areas where evidence is lacking. METHODS: The Cochrane Central Register of Controlled Trials and PubMed were searched for RCTs and the Cochrane Database of Systema…

OBJECTIVES: To perform a systematic up-to-date review and critical discussion of potential clinical applications of cangrelor based on its pharmacologic properties and the main findings from randomized clinical studies. METHODS: A database search (PubMed, CENTRAL and Google Scholar) by two independent investigators, i…

BACKGROUND: Venous thromboembolism (VTE) is a prevalent disease with potential serious consequences. Idraparinux and idrabiotaparinux are two kinds of long-acting pentasaccharides. Evidence has shown that idraparinux and idrabiotaparinux are effective anticoagulants. However, up to now, there is no consensus on whether…

Combining chemotherapy with preoperative radiotherapy (RT) has a sound radiobiological rationale. We performed a systematic review and meta-analysis of trials comparing preoperative RT with preoperative chemoradiation (CRT) in rectal cancer patients. The Cochrane Central Register of Controlled Trials, Web of Science, E…

OBJECTIVES: To assess how nurse to patient ratios and nurse work hours were associated with patient outcomes in acute care hospitals, factors that influence nurse staffing policies, and nurse staffing strategies that improved patient outcomes. DATA SOURCES: MEDLINE (PubMed), CINAHL, Cochrane Databases, EBSCO research…

Owing to the increasing disparity of organ demand and organ supply the search for optimal immunosuppressive strategies has become a central issue in kidney transplantation (KTX). In the focus today are modifications of the use of calcineurin-inhibitors (CNIs, Cyclosporine A/Tacrolimus) and steroids, as they are nephrot…

PURPOSE: This systematic review and meta-analysis aimed to characterize etiological patterns of uveitis in individuals aged 60 years or older. METHODS: Following the PRISMA 2020 and MOOSE reporting guidelines, we searched PubMed/MEDLINE, Scopus, PubMed Central (PMC), and Web of Science (January 1, 2005-January 1, 2025…

INTRODUCTION: Methoxyflurane (MOF) is a low-dose inhaled analgesic with rapid onset, patient-controlled titration, and an established safety profile at sub-anesthetic doses. Its potential role in oral and maxillofacial surgery (OMFS) has not been comprehensively mapped. OBJECTIVE: To map and characterize available evi…

Western Canadian and U.S. communities outside urban centres remain underserved by primary, specialist, emergency, mental health, and chronic-disease services. These access problems reflect distance, weather, workforce shortages, specialist maldistribution, primary care attachment gaps, broadband limitations, and the go…

BACKGROUND: Major depressive disorder (MDD) is a global cause of disability, with many patients experiencing suboptimal response to conventional treatments. Mindful breathing exercises, a simple and scalable technique, have emerged as a promising non-pharmacological intervention for alleviating depressive symptoms and…

BACKGROUND: Depressive disorders are clinically heterogeneous and mechanistically complex psychiatric conditions. Transcranial direct current stimulation (tDCS), a key non-invasive neuromodulation technique, has expanded rapidly in both therapeutic application and mechanistic research. However, the field is marked by r…

BACKGROUND: Infections with liver flukes (,, and.) cause high burden. Mechanistic models have been employed to disentangle their transmission dynamics and guide the design of control strategies. However, no comprehensive review of these mechanistic models has yet been undertaken. METHODS: In this systematic review, we…

BACKGROUND: This systematic review aimed to identify perinatal risk factors associated with obesity in children aged ≤5 years. METHODS: This studyfollowed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Medline (via PubMed), Embase, and Cochrane CENTRAL were searched from ince…

BACKGROUND: Diabetes mellitus is a global health challenge characterized by oxidative stress (OS) and persistent inflammation, which contribute to the progression of complications. Melatonin, a multifaceted hormone known for its potent antioxidant and anti-inflammatory properties, has emerged as a potential therapeutic…

BACKGROUND/OBJECTIVES: Early childhood caries (ECC) and saliva have been studied across disparate domains, including microbiome, fluoride, immune, oxidative-stress, and neuroendocrine research. However, the ECC-saliva literature has not previously been mapped as a connected system using modern natural language processi…

BACKGROUND: Irritable bowel syndrome (IBS) is a chronic functional disorder that significantly impacts patient health, causing physical discomfort and diminished quality of life. We aimed to compare various acupoint stimulation modalities for treating IBS using network meta-analysis (NMA). METHODS: We conducted a syst…

This paper explores the role of metrology in the assessment of image quality in the field of radiomics. Image Quality Assessment (IQA) is central to ensuring the reliability and reproducibility of radiomic analyses, as it directly affects the accuracy of feature extraction and segmentation, ultimately impacting diagnos…

To synthesize and critically appraise applications of machine learning (ML) in pediatric cardiac intensive care, focusing on algorithm performance, validation rigor, and readiness for clinical decision-support integration. Scoping review of studies applying ML to congenital heart disease (CHD) or pediatric cardiac inte…

OBJECTIVE: This systematic review will examine the association between pesticide use and cancer incidence among farm workers. INTRODUCTION: Farmers are the most essential part of many countries' agriculture-based economies. Several studies have identified acute and chronic hazards associated with pesticide use, includ…