44,715 papers found

: Vitamin D plays an important role in immune regulation, and vitamin D deficiency has been increasingly associated with susceptibility to infection and adverse outcomes in critically ill patients. Numerous systematic reviews and meta-analyses have examined the relationship between vitamin D status, vitamin D receptor…

BACKGROUND: The aim of this systematic review was to evaluate the survival rates of computer-aided design/computer-aided manufacturing ceramic dental restorations. METHODS: The study followed PRISMA guidelines and the study protocol was pre-registered on the PROSPERO platform (registration number: CRD42024599053). Ran…

STUDY OBJECTIVES: Fetal sleep is a vital yet underexplored aspect of prenatal neurodevelopment. Its cyclic organization reflects the maturation of central neural circuits, and disturbances in these patterns may offer some of the earliest detectable signs of neurological compromise. This is the first review to integrate…

Non-pharmacological therapies have demonstrated efficacy in alleviating dementia-related symptoms in residential aged care settings; however, their uptake remains limited. This systematic review aimed to identify the barriers and facilitators influencing the implementation of non-pharmacological therapies for people wi…

BACKGROUND: Frailty is a prevalent geriatric syndrome associated with risk of disability, hospitalization, and mortality. Despite nutrition and exercise playing central roles in maintaining muscle mass and function, the specific effects of nutritional guidance, distinct from supplementation, remain unclear. OBJECTIVE:…

BACKGROUND: Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders, yet concerns about their long-term effects on cognitive function persist. Emerging evidence suggests a possible association between prolonged PPI use and increased dementia risk, though findings remain inconclusive. This narrati…

BACKGROUND: In recent years, evidence has increasingly highlighted the relationship between auditory processing and vocal function, suggesting that impairments in central auditory mechanisms may influence both the perception and regulation of voice production. Considering this relationship, mapping how auditory process…

INTRODUCTION: Systemic mastocytosis (SM) is a heterogeneous clonal disorder characterized by the accumulation of abnormal mast cells in various tissues, predominantly the bone marrow. Given the rarity of the disease, the available data in Romania are extremely limited. It is estimated that the total number of diagnosed…

INTRODUCTION: Artificial intelligence (AI) technologies are increasingly being developed and deployed to support clinical decision-making, care delivery and patient monitoring in healthcare. However, the adoption of AI-driven solutions by nurses, who comprise the largest segment of the healthcare workforce and are cent…

Neurological conditions including stroke, multiple sclerosis, and Parkinson's significantly contribute to disability and mortality globally. A significant proportion of these cases are found in Low and Middle Income Countries (LMICs). Telerehabilitation has emerged as a promising approach to overcome the geographical,…

PURPOSE: This systematic review aimed to investigate differences in chronic pain and foreign body sensation based on mesh placement, with recurrence as a secondary outcome. METHODS: The review was registered in PROSPERO (ID: CRD42024592114), and searches were conducted in MEDLINE (PubMed), Embase Ovid, and Cochrane CE…

Data on the genetics and molecular biology of diabetes are accumulating rapidly. This poses the challenge of creating research tools for a rapid search for, structuring and analysis of information in this field. We have developed a web resource, GlucoGenes®, which includes a database and an Internet portal of gene…

BACKGROUND: New approaches for the management of obesity, a worldwide problem and a major determinant of disability and mortality, are needed. Mastication influences appetite and satiety mechanisms via actual food or sham feeding. However, the effect of mastication of chewing gum, a type of sham feeding, on appetite re…

OBJECTIVE: This study aimed to investigate the most effective methods in controlling pain during debonding procedures. MATERIAL AND METHODS: Electronic searches in published and unpublished studies were performed. Restricted to the English language and publication date up to 23/3/2024, the searches in published litera…

INTRODUCTION: The aim of this systematic review was to determine the best treatment alternatives for patients with maxillary lateral incisor agenesis (MLIA) by comparing orthodontic space closure, implant and tooth supported dental prostheses by assessing studies that evaluated their periodontal, occlusal (function) an…

OBJECTIVE: To systematically review, summarize and appraise evidence on the factors determining quality of life (QoL) after total knee arthroplasty (TKA) in individuals with knee osteoarthritis. METHODS: We searched six databases (PubMed, Scopus, Web of Science, CINAHL, EMBASE, and ProQuest) using appropriate search t…

INTRODUCTION: In recent decades, there has been a proliferation of mobile health (mHealth) interventions to address public health challenges such as HIV/AIDS. Hence, there is a need for standardizing the report of mHealth interventions and frameworks to enable effective knowledge sharing and promote developments. This…

INTRODUCTION: Primary health care is a key element in the structuring and coordination of health systems, contributing to overall coverage and performance. PHC financing is therefore central in this context, with variations in sufficiency and regularity depending on the "political dimension" of health systems. Research…

INTRODUCTION: Over the recent years, scientific community has increased its interest on solving problems of female fertility pathology. Many factors acting separately or in combination affect significantly the reproductive life of a woman. This review summarizes current evidence regarding the direct and/or indirect act…

INTRODUCTION: Urethral multiplicity is a rare congenital anomaly characterized by the presence of two or more urethral channels. It is more common in males and can cause double urinary stream, incontinence, obstruction, and recurrent urinary infections. Diagnosis is difficult due to diverse clinical manifestations. Imp…