97,490 papers found

In the last few years there has been a veritable explosion of knowledge about cyclic nucleotide phosphodiesterases. In particular, the accumulating data showing that there are a large number of different phosphodiesterase isozymes have triggered an equally large increase in interest about these enzymes. At least seven…

The rapid development of nanotechnology during the last two decades has created new opportunities to design and generate more advanced nanotheranostics with diversified capabilities for diagnosis, drug delivery, and treatment response monitoring in a single platform. To date, several approaches have been employed in or…

In vitro maturation (IVM) is one of the most important steps in in vitro embryo production (IVEP). It is a complicated procedure in which nuclear and cytoplasmatic changes in oocytes appear. In order to carry out the in vitro maturation procedure correctly, it is necessary to provide the oocytes with as close to a natu…

Adenosine, a widely distributed modulator, regulates many physiological functions through specific cell membrane G-protein-coupled receptors classified as A(1), A(2A), A(2B) and A(3). An intense medicinal chemistry effort made over the last 20 years has led to a variety of selective adenosine receptor agonists and anta…

Time series analysis of out-patients at Urban Health Centre, Suraj Kund, Meerut, was done using the out-patient attendance of last five years, with the aim to find out the values to help in coping up with the problem of health administration and management. The least square method and ratio-to-trend method were adopted…

INTRODUCTION: Research and scholarly output are integral parts of residency training for both residents and faculty. With the transition to a single accreditation system, scholarly activity and output of osteopathic physicians have garnered significant interest. Previous research has shown that osteopathic physicians i…

: Elevated intraocular pressure (IOP) is the most prevalent risk factor for glaucoma. Prostaglandin analogs are a first-line therapy for glaucoma due to their ability to reduce IOP, once-daily dosing, efficacy, and minimal side-effect profile. Many compounds targeting different PG receptors have been developed in the l…

Little was known about the cancer burden for the last 40 years in middle-income province in China. This study aimed to assess the overall, cause-specific mortality cancer trend and disability-adjusted life years (DALYs) between 1973-1975 and 2011-2013 in North China (Hebei Province). The collected data were stratified…

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular mechanisms underlying the powerful actions of IL-5 finalized to the ind…

OBJECTIVE: Real-world data from adolescents treated with perampanel in a routine clinical setting are lacking in Japan. We evaluated the safety and efficacy of perampanel for adolescent patients (aged 12-17 years) with drug-resistant, refractory epilepsy in real-world settings. METHODS: This was a large-scale, prospec…

Visual snow is a persistent visual disturbance in which small dots of light appear across the visual field of both eyes, like snowfall. The condition is not widely known, but an increasing number of cases have been described in the last 5 - 6 years. Many patients have consulted a number of specialists without…

•More than 70% of all deaths in the BRICS countries are attributable to noncommunicable diseases.•There have been marked changes in physical activity levels, time use, and energy expenditure in these nations over the last 20 years.•There are marked gender differences in physical activity in 4 of th…

Applications of conducting polymers to biosensors have recently aroused much interest. This is because these molecular electronic materials offer control of different parameters such as polymer layer thickness, electrical properties and bio-reagent loading, etc. Moreover, conducting polymer based biosensors are likely…

Heart failure is a common clinical problem, affecting at least 5 million Americans. There have been substantial advances in the understanding and treatment of heart failure in the last several years. We review current concepts for the evaluation and treatment of the various manifestations of patients with heart failure…

The authors presented 6 cases of malignant neoplasms of intestine. Five of them were undergone emergency surgery, while one elective, due to complaints notified previously for a longer time. In all cases a segmental resection of intestine was done. Two patients were complementarily treated using chemiotherapeutics. Thr…

In the last 5 years we have performed 14 phase I studies in our department. Eight of these trials involved evaluation of both the clinical and the pharmacokinetic behaviour of novel anti-cancer agents. The remainder investigated various aspects of drug delivery, targetting or resistance modification with existing anti-…

A case of massive chronic fetomaternal transfusion with a loss of 500 ml blood is reported. A review of 24 cases covering the last 10 years shows that chronic fetomaternal transfusions do not lead to intrauterine dystrophy. During birth there is a danger of acute decompensation, which led to an irreversible shock and d…

The benign systemic disorders with involvement of the spleen are divided into haematologic diseases, thesaurismosis, collagenosis, morbus Boeck, infectious diseases, parasitosis and others. 4/5 of the cases are haematologic diseases of the erythrocytic, the thrombocytic and lymphatic system as well as myeloproliferativ…