44,621 papers found

CXCR3 is a well-known receptor involved in immune cell recruitment and inflammation. Pathological inflammation leads to pain stimulation and hence nociception. Therefore, we decided to review the recent research on CXCR3 to identify its precise role in the modulation of pain in a variety of clinical conditions targetin…

BACKGROUND: In infants, apneas can be centrally mediated, obstructive or both and have been proposed to be gastroesophageal reflux (GER) induced. Evidence for this possible association has never been systematically reviewed. PURPOSE: To perform a systematic review using PubMed, EMBASE and Cochrane databases to determi…

The open access (OA) or the idea of a free access to scholarly literature published in electronic form has been already well established in the field of medicine. Medline has already been free for a decade, PubMed Central has been growing steadily. The global crisis of the scientific publishing, becoming increasingly d…

This article discusses the environment leading to the founding of the Pubmed Central database, and its likely effects on publishing as we know it.

The launch of, which is fully compliant with Plan S, has extended our author base and allowed readers worldwide to access the content for free. PubMed Central (PMC) has recently approved the journal for indexing (including indexing by PubMed), which will further improve visibility and access. Because authors retain cop…

BACKGROUND: Many bibliographic databases index research studies evaluating the effects of health care interventions. One study has concluded that the Physiotherapy Evidence Database (PEDro) has the most complete indexing of reports of randomized controlled trials of physical therapy interventions, but the design of tha…

INTRODUCTION: Female sexual dysfunction (FSD) at menopause is a group of prevalent and multifactorial conditions that significantly impair quality of life and well-being. Hormonal decline, particularly estrogen and androgen deprivation, along with aging-related changes, contribute to genitourinary syndrome of menopause…

INTRODUCTION: Clomiphene citrate (CC) is a selective estrogen receptor modulator that has been used for the treatment of hypogonadism in men since the 1970s. It acts centrally to increase secretion of luteinizing hormone and follicle-stimulating hormone, thereby increasing testosterone production and serum levels. Unli…

Mohs micrographic surgery (MMS) is a highly effective treatment for skin cancers, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), especially in cosmetically sensitive areas. Despite its high cure rates, the procedure's impact on psychosocial outcomes, influenced by demographic, clinical, psycholog…

Oocyte morphology assessment is easy to implement in any laboratory with possible quality grading prior to fertilization. At present, comprehensive oocyte morphology scoring is not performed as a routine procedure. However, it may augment chances for successful treatment outcomes if a correlation with certain dysmorphi…

Eye tracking has emerged as a reliable neuroscience tool indexing the eye movements' correlates of impairments resulting from alcohol-use disorders, ranging from perceptive abilities to high-level cognitive functions. This systematic review, following PRISMA guidelines, encompasses all human studies using eye tracking…

: Gastroparesis is a chronic disorder of the stomach characterized by delayed gastric emptying without mechanical obstruction. Diabetes is the most commonly known cause of gastroparesis. Management of diabetic gastroparesis involves lifestyle modifications, glycemic control, pharmacological drugs, and for refractory ca…

WHAT IS KNOWN AND OBJECTIVE: The increasing prevalence of obesity and associated morbidity present unmet medical needs for safe and effective new drug therapies. Our aim is to review the diverse targets and compounds that are in clinical development. METHODS: Literature searches were conducted using the PUBMED databas…

Thiocolchicoside is a colchicoside compound that is partly synthetic and is most known for its characteristics of centrally acting muscle relaxants. It has been widely used in the management of musculoskeletal disorders due to its ability to modulate inhibitory neurotransmission. Recent research has shown potential in…

Metastasis of ovarian cancer to the breast (MOCB) is a rare event. Clinical presentations of MOCB vary and surgery is the mainstay of treatment. The current study presents two cases of MOCB in women with recurrent ovarian cancer first diagnosed in April 2011 and October 2013, respectively. The patients presented to the…

OBJECTIVE: International and societal conflicts and natural disasters can leave physical and mental scars in people who are directly affected by these traumatic experiences. Posttraumatic stress disorder (PTSD) is the clinical manifestation of these experiences in the form of re-experiencing the trauma, avoidance of tr…

Does PubMed Central--a government-run digital archive of biomedical articles--compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology,…

BACKGROUND: Systematic literature searches are the cornerstone of systematic reviews. In this study, we evaluated database coverage of randomized clinical trials for central serous chorioretinopathy (CSC). METHODS: We searched 12 databases (BIOSIS Previews, CINAHL, the Cochrane Central, Current Contents Connect, Data…