43,327 papers found

Major depressive disorder (MDD) and treatment-resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor-level treatment strategies beyond monoamine reuptake. The serotonin 5-HT2B receptor (5-HT2BR) is uniquely positioned at the interface of central-antidepressant mechanisms and…

INTRODUCTION: Persistent breathlessness is a debilitating symptom that is prevalent in the community, particularly in people with chronic and life-limiting illnesses. Treatment includes different steps, including pharmacological treatment aiming to improve the symptom and optimize people's wellbeing. AREAS COVERED: Pu…

To assess centrally mediated analgesic mechanisms in clinical trials with pain patients, objective standardized methods such as electroencephalography (EEG) has many advantages. The aim of this review is to provide the reader with an overview of present findings in analgesics assessed with spontaneous EEG and evoked br…

CXCR3 is a well-known receptor involved in immune cell recruitment and inflammation. Pathological inflammation leads to pain stimulation and hence nociception. Therefore, we decided to review the recent research on CXCR3 to identify its precise role in the modulation of pain in a variety of clinical conditions targetin…

BACKGROUND: In infants, apneas can be centrally mediated, obstructive or both and have been proposed to be gastroesophageal reflux (GER) induced. Evidence for this possible association has never been systematically reviewed. PURPOSE: To perform a systematic review using PubMed, EMBASE and Cochrane databases to determi…

CONTEXT: Flavones, the key active components in Traditional Chinese Medicine (TCM), have demonstrated antidepressant activity. Given the numerous animal studies conducted, a systematic analysis is essential to provide a valuable reference for future research. OBJECT: This study investigated the antidepressant activity…

Stereotactic body radiotherapy (SBRT) enables high-precision, high-dose treatment of liver lesions with acceptable toxicity. With the introduction of flattening filter-free (FFF) beams and the use of different photon energies, there is potential for improved dosimetry and treatment efficiency; however, the optimal sele…

Does PubMed Central--a government-run digital archive of biomedical articles--compete with scientific society journals? A longitudinal, retrospective cohort analysis of 13,223 articles (5999 treatment, 7224 control) published in 14 society-run biomedical research journals in nutrition, experimental biology, physiology,…

It is with great pleasure and proud that we can announce that Diagnostics is now indexed and searchable in PubMed.[...].

OBJECTIVE: Cerebral arteriovenous malformations (AVMs) are vascular lesions whose pathogenesis, although not fully elucidated, is likely multifactorial. Recent research investigating vessel development suggests a potential hierarchical model in which capillary sprouts from higher-flow arteries give rise to lower-flow v…

BACKGROUND: The incidence of colon cancer is increasing in Norway and about 2200 new cases are now diagnosed each year. This paper presents accepted principles of the surgical treatment of the disease. MATERIAL AND METHODS: The article is based on literature retrieved from the PubMed and Cochrane databases, guidelines…

Mohs micrographic surgery (MMS) is a highly effective treatment for skin cancers, such as squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), especially in cosmetically sensitive areas. Despite its high cure rates, the procedure's impact on psychosocial outcomes, influenced by demographic, clinical, psycholog…

Oocyte morphology assessment is easy to implement in any laboratory with possible quality grading prior to fertilization. At present, comprehensive oocyte morphology scoring is not performed as a routine procedure. However, it may augment chances for successful treatment outcomes if a correlation with certain dysmorphi…

Eye tracking has emerged as a reliable neuroscience tool indexing the eye movements' correlates of impairments resulting from alcohol-use disorders, ranging from perceptive abilities to high-level cognitive functions. This systematic review, following PRISMA guidelines, encompasses all human studies using eye tracking…

: Gastroparesis is a chronic disorder of the stomach characterized by delayed gastric emptying without mechanical obstruction. Diabetes is the most commonly known cause of gastroparesis. Management of diabetic gastroparesis involves lifestyle modifications, glycemic control, pharmacological drugs, and for refractory ca…