4,999,465 papers found

OBJECTIVE: Aged care services increasingly respond to the needs of people with dementia. Non-pharmacological approaches are preferable to reduce responsive behaviours, improve/maintain functional capacity and reduce emotional disorders. This rapid review of systematic reviews aimed to consolidate the evidence for non-p…

In this review the usual methods applied in systematic reviews and meta-analyses are outlined. The ideal hypothesis for a systematic review should be generated by information not used later in meta-analyses. The selection of studies involves searching in web repertories, and more than one should be consulted. A manual…

Taking into account the rising trend of the incidence of cancers of various organs, effective therapies are urgently needed to control human malignancies. However, almost all of the chemotherapy drugs currently on the market cause serious side effects. Fortunately, several previous studies have shown that some non-toxi…

Extracranial metastases from glioblastoma (GBM) are uncommon with an estimated incidence of less than 2%. We report two cases of metastatic GBM seen within an 8-week period followed by a literature review. We attempted to identify common factors or a causative mechanism. Factors that predominated among the reviewed cas…

PURPOSE OF REVIEW: The review critically appraises the available evidence and current rationale for treating incidental intracranial aneurysms. RECENT FINDINGS: The rationale for treating incidental intracranial aneurysms uses comparisons between the so-called natural history, provided in a recent meta-analysis, and r…

BACKGROUND: Understanding of data-reporting methods is imperative for correct interpretation of the medical literature as well as for proper performance of future clinical research. Recent developments in biostatistics have greatly changed the types of statistical analyses used and the minimum quality standards that mu…

Current methods for developing practice guidelines include informal consensus development, formal consensus development, evidence-based guideline development, and explicit guideline development. Informal consensus development is the oldest and most common approach, but guidelines produced in this manner are often of po…

INTRODUCTION: With recent higher awareness of the necessity of improving healthcare workers' well-being, we aimed to overview systematic reviews dealing with interventions on well-being, occupational health, and aging of healthcare workers. METHODS: From three databases (PubMed, Embase, and Web of Science), a scoping…

Induction of labour is one of the most common interventions experienced by pregnant women. There are two overlapping components to labour induction, which include cervical ripening and the initiation of regular contractions. A large number of clinical studies have been conducted for evaluating the methods used for indu…

This paper reviews the concept of risk of bias, followed by demonstrating why assessment of risk of bias in systematic reviews should be different from that of quality of evidence, methodological quality, reporting quality, precision, and external validity. We also discuss the recent development of tools for risk of bi…

BACKGROUND: The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, sneezing, cough, malaise, sore throat, and fever (usually < 37.8 &#xba;C). Whilst the common cold is generally not harmful, it is a cause of economic burden due to school a…

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the…

PURPOSE OF REVIEW: Effective communication in cancer care requires complex communication skills of healthcare professionals (HCPs), which can be advanced by communication skills training (CST). The number of empirical studies on CST has grown steadily over the last decade. However, controversies on CST abound. The aim…

This review aimed to identify and appraise all systematic reviews of palliative care services, to examine their findings in relation to methods used, and to explore whether further methods such as meta-analysis and meta-regression may be worthwhile. Ten databases were searched and augmented by hand searching specific j…

Documenting systematic searches promotes transparency, reproducibility, and integrity in research. In recent years, various reporting guidelines have gained widespread recognition and adoption, and some journals and funders require researchers to provide a detailed account of their search strategies. Documentation of s…

Depression is a well-known co-morbidity of cancer. A possible intervention for depression is psychological treatment defined as psychotherapy provided by a psychologist. In this narrative review we investigated the effect of psychological treatment on depression for patients with cancer. Six Cochrane reviews of 38 stud…

This clinical review on the treatment of patients with gastroparesis is a consensus document developed by the American Motility Society Task Force on Gastroparesis. It is a multidisciplinary effort with input from gastroenterologists and other specialists who are involved in the care of patients with gastroparesis. To…

Three aspects of the role of clinical evidence in guiding therapy in the field of neonatology are presented: 1) what is embodied in the concept "evidence-based medicine"? 2) the contribution of the Cochrane Collaboration and its Neonatal Review Group in summarizing and disseminating evidence, in the form of systematic…

OBJECTIVE: To identify any medical or public health rationale for claims that the time to act is now. DESIGN: Pseudo-systematic review. DATA SOURCES: PubMed. STUDY SELECTION: Studies that included the claim "time is now" in the title, with or without exclamation marks. No language or date restriction was applied. R…