42,426 papers found

BACKGROUND AND OBJECTIVES: Neuroplasticity evidence from animals favors an early enriched environment for promoting optimal brain injury recovery. In infants, systematic reviews show environmental enrichment (EE) improves cognitive outcomes but the effect on motor skills is less understood. The objective of this review…

OBJECTIVES: Injury surveillance in the pediatric emergency department (PED) has the potential to be an important part of program planning and clinical management. However, a lack of data has been identified as one of the critical limitations in the field of pediatric emergency services research. The aims of this articl…

INTRODUCTION: The objective of this systematic review was to assess the short- and long-term release of components of orthodontic adhesives and polycarbonate brackets in the oral environment. METHODS: Electronic database searches of published and unpublished literature were performed. The following electronic database…

BACKGROUND: It has been reported that sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have been more effective than bare-metal stents in reducing restenosis and cardiac events in a broad range of patients with coronary artery disease. However, it is unknown whether there might be differences between…

CONTEXT: Emerging evidence suggests that sedentary behavior (i.e., time spent sitting) may be negatively associated with health. The aim of this study was to systematically review the evidence on associations between occupational sitting and health risks. EVIDENCE ACQUISITION: Studies were identified in March-April 20…

BACKGROUND AND PURPOSE: The optimal treatment for isolated patellofemoral osteoarthritis is unclear at present. We systematically reviewed the highest level of available evidence on the nonoperative and operative treatment of isolated patellofemoral osteoarthritis to develop an evidenced-based discussion of treatment o…

In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through the NCBI web site. NCBI resources include Entrez, the Entrez Programming Util…

BACKGROUND: Explosive growth of hospital-based medicine specialists, termed hospitalists, has occurred in the past decade. This was fueled by pressures within the American health care system for timely, cost-effective, and high-quality care and by the growing chasm between inpatient and outpatient care. In this article…

The public health sector is undergoing sustained change, shaped by complex health challenges, constrained resources, and evolving employment conditions that may affect the availability of stable and fulfilling career pathways for public health professionals. Within this context, the integration of entrepreneurial compe…

BACKGROUND: With improving survival in breast cancer, supportive care has increasingly focused on long-term, treatment-related symptom clusters (e.g., pain, fatigue, vasomotor symptoms, insomnia, and anxiety) that impair quality of life and adherence. Within integrative oncology, non-pharmacological Traditional Chinese…

BACKGROUND AND OBJECTIVES: Patient engagement is central in managing chronic conditions. Engagement may be particularly challenging for older adults with their age-related changes. However, the concept and strategies for promoting patient engagement among older adults remain underdeveloped. We conducted a scoping revie…

Male stress urinary incontinence (UI), particularly after radical prostatectomy, remains a clinically relevant condition with a detrimental impact on patients' quality of life. Non-adjustable male slings are widely used for the treatment of this condition. Although baseline UI severity is an established predictor of sl…

BACKGROUND: Unhealthy lifestyles are associated with gut microbiota dysbiosis through complex inflammatory and immune-related pathways. Despite extensive primary research, comprehensive big-data syntheses mapping this field remain limited. This study systematically analyzes the research landscape, related pathophysiolo…

INTRODUCTION: A subset of patients with acute appendicitis presents with complicated disease characterized by periappendiceal abscess. Although appendiceal neoplasms are rare in uncomplicated appendicitis, recent evidence suggests a higher incidence in patients with appendicitis complicated by abscess, particularly in…

BACKGROUND: Monkeypox, a zoonotic viral disease caused by the monkeypox virus (MPXV), was first identified in captive monkeys in 1958 and in humans in 1970. Although historically limited to Central and West Africa, the unprecedented 2022–2025 multi-country outbreaks exposed its ability for sustained human-to-hum…

: Vitamin D plays an important role in immune regulation, and vitamin D deficiency has been increasingly associated with susceptibility to infection and adverse outcomes in critically ill patients. Numerous systematic reviews and meta-analyses have examined the relationship between vitamin D status, vitamin D receptor…

BACKGROUND: Pharmacology plays a central role in linking biomedical science concepts with their application in clinical practice across medical and healthcare education. Globally, the pharmacological curriculum has evolved, just like other disciplines, through the integration of case-based, problem-based, and hybrid te…

BACKGROUND: The aim of this systematic review was to evaluate the survival rates of computer-aided design/computer-aided manufacturing ceramic dental restorations. METHODS: The study followed PRISMA guidelines and the study protocol was pre-registered on the PROSPERO platform (registration number: CRD42024599053). Ran…

Non-pharmacological therapies have demonstrated efficacy in alleviating dementia-related symptoms in residential aged care settings; however, their uptake remains limited. This systematic review aimed to identify the barriers and facilitators influencing the implementation of non-pharmacological therapies for people wi…

BACKGROUND: Proton pump inhibitors (PPIs) are widely prescribed for acid-related disorders, yet concerns about their long-term effects on cognitive function persist. Emerging evidence suggests a possible association between prolonged PPI use and increased dementia risk, though findings remain inconclusive. This narrati…