11,614,922 papers found

PURPOSE: This systematic review examines the current landscape of artificial intelligence (AI)-based Clinical Decision Support Systems (CDSS) designed to aid in the treatment of depression. With depression recognized as a complex and multifactorial condition, often differing across contexts such as postpartum, adolesce…

Lead strangulation is a dangerous complication of epicardial pacemaker insertion. This complication has been increasingly highlighted lately. Our institution has recently identified four cases over the past five years. This study's aim was to 1) identify risk factors for strangulation and 2) prospectively screen existi…

BACKGROUND: Effective public financial management (PFM) is a foundational enabler of sustainable progress toward Universal Health Coverage (UHC). Achieving UHC requires not only increased funding for the health sector but also the efficient, equitable, and accountable use of resources. In 2019, Kenya piloted a UHC init…

INTRODUCTION: Experiences by service members in recent conflicts and training environments illuminate concerns about the possible effects of blast overpressure (BOP) exposure on brain health. Section 734 of the National Defense Authorization Act for Fiscal Year (FY) 2018 (Public Law 115-91) requires that the Secre…

Liposomes are utilized as a drug delivery carrier in various fields of biomedicine. They are synthesized in the nanometer-size range and are becoming a viable drug delivery carrier for the treatment of different diseases. MicroRNAs as regulatory elements could be transferred to cells for changing their morphology or ph…

BACKGROUND: To investigate whether diabetes contributes to mortality for major types of diseases. METHODS: Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population o…

We evaluated the antiplatelet effects of two classes of ATP-sensitive potassium channel openers (K(ATP) openers) on washed human platelets, and the study's emphasis was on the role of mitochondrial K(ATP) in platelet aggregation. Collagen-induced platelet aggregation was inhibited in a dose dependent manner by lemakali…

BACKGROUND: Bile acid diarrhoea (BAD) causes chronic diarrhoea and is primarily treated pharmacologically. This systematic review aimed to evaluate the effectiveness of non-pharmacological therapies for evidence-based management of BAD in adults. METHODS: A systematic review of the medical literature was performed fro…

This study compares the kernel equating (KE) and test characteristic curve (TCC) equating methods using the nonequivalent anchor test equating design. In this Monte Carlo study, four independent variables were examined: sample size, test length, average form discrimination, anchor test reliability, and the percentage o…

Sampling is a key feature of every study in developmental science. Although sampling has far-reaching implications, too little attention is paid to sampling. Here, we describe, discuss, and evaluate four prominent sampling strategies in developmental science: population-based probability sampling, convenience sampling,…

Noonan syndrome (NS; OMIM 163950) is an autosomal dominant RASopathy with variable clinical expression and genetic heterogeneity. Clinical manifestations include characteristic facial features, short stature, and cardiac anomalies. Variants in protein-tyrosine phosphatase, non-receptor-type 11 (PTPN11), encoding SHP-2,…

INTRODUCTION: Give the significant and diverse impact of in-vehicle distractions on road crashes, this study examines the comparative impact of four inside-vehicle distractions (auditory, visual, behavioral/manual and cognitive) on driving performance. METHOD: A lab-based driving simulator study was conducted with Aus…

Clinicians across the globe face overwhelming dissatisfaction and burden with electronic health records due to poor usability and the sheer volume of data collection requirements. In the United States, electronic health records are noted to be a principal source of distress, dissatisfaction, and endless workarounds, le…

Credibility of scientific claims is established with evidence for their replicability using new data. According to common understanding, replication is repeating a study's procedure and observing whether the prior finding recurs. This definition is intuitive, easy to apply, and incorrect. We propose that replication is…

Engaging a diverse stakeholder group, including patients, clinicians, policy makers, and leadership from national professional organizations as partners in research supports the pursuit of patient-centered outcomes. Utilizing the Patient-Centered Outcomes Research (PCOR) Engagement Principles and applying adult learnin…

OBJECTIVE: This study's objective was to understand how art therapy and mindfulness meditation could be integrated together in the context of different cultures and political violence and in work with asylum seekers suffering from trauma. METHOD: We conducted a qualitative phenomenological study based on the social co…

BACKGROUND: Uncontrolled crying (UC) is a prevalent poststroke phenomenon of elderly patients, socially disabling and interfering with rehabilitation. There are many differences in opinions and nonclarity in the literature relating to UC. OBJECTIVE: To examine two basic questions regarding UC that have as yet not been…

This study investigated the influence of patient and provider gender on the outcomes of medication-history interviewing. In a previous study, 112 pharmacy students conducted medication-history interviews with 2 simulated patients. A secondary analysis was accomplished using complete data from 85 of the original 112 pha…

INTRODUCTION: Low Molecular Weight Heparins (LMWHs) and Fondaparinux have been widely used as anticoagulants. Mass prescription may lead to prescriptive inappropriateness, which causes Heparin-induced thrombocytopenia and other side effects. OBJECTIVES: The study investigates the appropriate prescription of LMWHs and…

INTRODUCTION: This study's objective was to systematically review the literature to assess analgesic outcomes of intravenous (IV) acetaminophen for acute postoperative pain in adults. METHODS: We searched Medline and the Cochrane library (January 1, 2000 to January 17, 2010, date of last search) for prospective, rando…