42,426 papers found

INTRODUCTION: Extant literature suggests that anhedonia, defined as a loss of the ability to feel pleasure or interest, is subserved by dysregulation of reward processing in the central nervous system. Dextromethorphan (DXM), an uncompetitive N-Methyl-d-Aspartate (NMDA) receptor antagonist and sigma-1 (σ1) recept…

BACKGROUND AND AIM: Superficial musculoaponeurotic system (SMAS) rhytidectomy techniques are widely used in facelift surgery to achieve long-lasting facial rejuvenation. Nonetheless, variations in technique lead to differences in complication rates, aesthetic outcomes, and longevity of results. Current literature lacks…

BACKGROUND: Incontinence is a widespread and socially taboo phenomenon worldwide. Incontinence, with its various manifestations, is one of the most common illnesses in outpatient medical care and represents a serious health problem for those affected of all ages. As part of the second update of the German expert standa…

BACKGROUND: Food cravings (FCs) are well-established as a significant factor in obesity. Despite their critical importance, mainstream anti-obesity interventions, including dietary programs and anti-obesity medications, often overlook FCs. While several studies have explored the impact of decentering on FCs, a comprehe…

BACKGROUND AND PURPOSE: Auriculotherapy for cancer-related fatigue has been investigated in various clinical trials; nonetheless, their conclusions remain inconsistent. In this systematic review and meta-analysis, the efficacy and safety of auriculotherapy for cancer-related fatigue were investigated. METHODS: Randomi…

PURPOSE: Individuals with advanced dementia often endure high symptom burden and receive limited specialized palliative care. Nurses play a central role in delivering end-of-life care, yet the impact of nurse-led interventions remains underexplored. This review synthesizes available evidence on nursing-led approaches,…

INTRODUCTION AND AIMS: Denture biofilm is associated with various oral and systemic diseases. Therefore, an effective denture-cleaning method should be adopted by denture wearers. This systematic review aimed to evaluate the efficacy of ultrasonic denture cleaning in reducing plaque quantity and microbial load and chan…

BACKGROUND: Direct-to-implant (DTI) breast reconstruction has become a widely accepted approach for postmastectomy breast reconstruction. Traditionally, implants were placed in the subpectoral (SP) plane to maximize soft tissue coverage; however, recent advances in surgical technique and implant materials, such as acel…

BACKGROUND: The vascular endothelium regulates capillary permeability and inflammation; its function predicts cardiovascular risk and mortality. Low-intensity therapeutic ultrasound (LITUS) may influence endothelial function, but the effects remain uncertain. OBJECTIVE: This systematic review with meta-analysis of cli…

BACKGROUND: Mobile health (mHealth) is an accessible strategy to deliver health information and is becoming increasingly popular as a form of follow-up among medical staff. However, the effects of mobile health on the physical and mental health outcomes of patients with prostate cancer after discharge from the hospital…

Coronary artery disease and atherosclerosis are a very significant and widespread problem in modern medicine. The development of current diagnostics and treatment of atherosclerotic lesions is moving towards minimally invasive methods. The purpose of this article is to present selected novel methods of treating coronar…

BACKGROUND: Glutamate is implicated in playing a crucial role in modulating the complex pathophysiological mechanisms of migraines, including central or peripheral sensitization, cortical spreading depression, and pain transmission. With expanding knowledge over the last three decades, glutamate receptors have become f…

OBJECTIVE: To systematically evaluate the effectiveness of respiratory training interventions in the rehabilitation of patients with rib fractures through a meta-analysis, aiming to provide robust evidence for clinical practice. METHODS: A comprehensive search was conducted in multiple databases (Pubmed, Embase, Web o…

BACKGROUND: Despite a global drop of under-five mortality by 59% between 1990 and 2019, it remains high in Low- and Middle- income Countries (LMICs)with a preponderance in Sub-Saharan Africa (SSA), Southern and Central Asia. Besides preterm and intrapartum complications, undernutrition contributes 45% of the deaths in…

OBJECTIVES: Urinary catheterization is a common procedure in the perioperative management of patients with hip fracture. However, decisions on its insertion or removal are often variable. This systematic review aimed to synthesize current evidence on urinary catheterization management in older patients with hip fractur…

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major global non-communicable disease, leading to increased morbidity and mortality. Its prevalence in Nigeria is driven by various risk factors. This review assesses the national and regional prevalence and risk factors of T2DM in Nigeria. METHODS: Following PRISMA gui…

Alzheimer's disease, a progressive neurodegenerative pathology, is characterized by the accumulation of Amyloid-β plaques in the brain. Lecanemab (BAN2401), a humanized IgG1 monoclonal antibody, binds with high affinity to Amyloid-β protofibrils. It is the first monoclonal antibody for Alzheimer's disease t…

Acute ischemic stroke (AIS) is a common cause behind a significant number of people who develop disabilities or die worldwide. Most of the strokes that occur globally are attributed to AIS as a result of large vessel occlusions that typically occur in arteries like the internal carotid and middle cerebral arteries. Pri…

Lipoprotein(a), or Lp(a), was identified in the early 1960. Its role as an independent risk factor for atherosclerotic cardiovascular disease (ASCVD) became widely recognized by the late 20th century, regardless of other traditional risk markers such as low-density lipoproteins and high-density lipoproteins. This…

One of the most prevalent childhood illnesses in the world, acute otitis media (AOM), is mainly brought on by, which has resulted in a significant increase in the use of antibiotics and the emergence of antibiotic-resistant (ABR) strains. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2…