44,713 papers found

RATIONALE: Violence and drug use are significant public health challenges that are strongly linked. It is known that alcohol plays a major role in the causation of unnatural deaths and that stimulants like cocaine and amphetamine are often implicated in aggressive acts or violence. However, a clear causal relationship…

Central line-associated bloodstream infection (CLABSI) and catheter-associated urinary tract infection (CAUTI) are costly and morbid. Despite evidence-based guidelines, Some intensive care units (ICUs) continue to have elevated infection rates. In October 2015, we performed a systematic search of the peer-reviewed lite…

BACKGROUND: Noninvasive hemoglobin (Hb) monitoring devices are available in the clinical setting, but their accuracy and precision against central laboratory Hb measurements have not been evaluated in a systematic review and meta-analysis. METHODS: We conducted a comprehensive search of the literature (2005 to August…

BACKGROUND: The use of antimicrobial-impregnated central venous catheters (CVCs) for the prevention of CVC microbial colonization and catheter-related bloodstream infection (CRBSI) remains controversial. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) evaluating CRBSI and colonization of C…

BACKGROUND: Chronic opioid use has been associated with the development of sleep-disordered breathing (SDB) such as central sleep apnea (CSA). Patients receiving chronic opioids may suffer from unrecognized sleep apnea that contributes to opioid-overdose death. Currently, information regarding the perioperative managem…

BACKGROUND: Neuromodulation is increasingly used for chronic neuropathic pain, but the comparative efficacy of invasive and non-invasive techniques remains unclear. This systematic review and network meta-analysis compared different neuromodulation interventions for chronic central and peripheral neuropathic pain. MET…

PURPOSE: This study systematically reviewed the fatigue mechanisms that constrain trail running performance and examined the influence of sex and event distance on these responses. PRISMA guidelines were followed. PubMed, Web of Science, and Dimensions AI databases were searched up to August 10, 2025 for studies involv…

BACKGROUND: Inhibitory control is a key component of executive function, influencing academic achievement, behavior, and long-term outcomes in children and adolescents. Physical activity (PA) has been identified as a potential intervention to improve inhibitory control, but the optimal type and dosage remain uncertain.…

OBJECTIVES: To evaluate the long-term clinical efficacy of dentin desensitizing agents with mechanisms of action by tubular occlusion, neural effect or both, for the treatment of dentin hypersensitivity (DH). DATA AND SOURCES: Following electronic databases: Pubmed (MEDLINE), Cochrane Central Register of Controlled Tr…

BACKGROUND: Tibial eminence fractures are common injuries that can cause significant functional limitations and require timely and effective treatment. Arthroscopic screw fixation and suture fixation are the primary methods used for managing displaced fractures. This study aimed to compare the functional and clinical o…

BACKGROUND/AIMS: Preoperative serum hypoalbuminemia (<3.5&#xa0;g/dL) is the blanketed referenced threshold associated with postoperative readmission, reoperation, and mortality among medical and surgical patients. This systematic review and meta-analysis evaluates the specific role of preoperative serum albumin and rea…

INTRODUCTION: &#xa0;Lung transplant candidates (LTC) and recipients (LTR) frequently suffer from impaired exercise capacity and reduced quality of life. Telerehabilitation (TR) offers a viable alternative for patients with limited access to center-based rehabilitation. METHODS: This systematic review assessed TR's cli…

Left ventricular thrombus (LVT) is a serious complication associated with myocardial infarction and cardiomyopathy. While vitamin K antagonists (VKAs) have been the standard treatment, direct oral anticoagulants (DOACs) offer potential advantages. This meta-analysis compares the efficacy and safety of DOACs versus VKAs…

INTRODUCTION: The reported incidence of pediatric facial fractures is relatively low, within age limits of up to 5&#xa0;years, whereas prevalence increases in children and adolescents. Considering the active growth that takes place in children, maxillofacial trauma can have deleterious effects if it involves growth cen…

BACKGROUND: To determine and review the currently available literature behind the staging capabilities of 18F-PSMA-1007 PET/CT in the setting of initial staging and detection of recurrent disease for patients with prostate cancer. Prostate cancer (PCa), one of the most diagnosed malignancies affecting adult men worldwi…

BACKGROUND: This systematic review aims to provide an updated summary of the available evidence on the role of platelet-rich fibrin (PRF) in the treatment of alveolar osteitis. MATERIAL AND METHODS: Searches were conducted in several electronic databases, including PubMed, EBSCO, Cochrane Central Register of Controlle…

BACKGROUND: Considerable interindividual variability for the pharmacokinetics of caffeine in preterm infants has been demonstrated, emphasizing the importance of personalized dosing. This study aimed to develop and apply a repository of currently published population pharmacokinetic (PopPK) models of caffeine in preter…

UNLABELLED: Liver cirrhosis is a chronic condition of the liver and is the 14th most common cause of death around the world; yet it remains an incurable disease. Probiotics have gained significant popularity as a potential treatment option for liver cirrhosis. METHODS: A systematic review and meta-analysis was conduct…

INTRODUCTION: Alcoholic liver disease (ALD) encompasses a spectrum of liver conditions, including liver steatosis, alcoholic hepatitis (AH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). microRNAs (miRNAs) have garnered significant interest as potential biomarkers for ALD. METHODS: We searched PubMed, Embas…

Several studies have indicated that miRNAs play crucial roles in adipogenesis, insulin resistance, and inflammatory pathways associated with obesity and change after metabolic bariatric surgery (MBS). This systematic review explores and maps the existing literature on how miRNAs are expressed and investigates the uniqu…