382,278 papers found

The presence and impact of heterogeneity in the standard one-way random effects model in meta-analysis are often assessed using the Q statistic due to Cochran. We derive the exact distribution of this statistic under the assumptions of the random effects model, and also suggest two moment-based approximations and a sad…

Meta-analysis of receiver operating characteristic (ROC)-curve data is often done with fixed-effects models, which suffer many shortcomings. Some random-effects models have been proposed to execute a meta-analysis of ROC-curve data, but these models are not often used in practice. Straightforward modeling techniques fo…

OBJECTIVE: The study aimed to review the conclusion of a previously published meta-analysis which quantified distinct superiority of cognitive therapy to antidepressant drug-therapy (P < 0.0001). METHOD: We sought to include all studies used in the original meta-analysis. Adopting both that study's inclusion criteria…

In meta-analysis of clinical trials, often meta-regression analyses are performed to explain the heterogeneity in treatment effects that usually exist between trials. A popular explanatory variable is the risk observed in the control group, the baseline risk. The relationship between the treatment effect and the baseli…

We explored the power and consistency to detect linkage and association with meta-analysis and pooled data analysis using Genetic Analysis Workshop 14 simulated data. The first 10 replicates from Aipotu population were used. Significant linkage and association was found at all 4 regions containing the major loci for Ko…

OBJECTIVE: To examine the results of meta-analyses in otolaryngology and compare these results with the individual component studies that constitute each meta-analysis. DESIGN: A retrospective review of the literature. MAIN OUTCOME MEASURES: Studies that conducted pooled statistical systematic analyses indexed on MED…

International experiences reveal the important role played by scientific research and systematic study a problems, in effectively tackling change in the health sector. Meta-analysis was introduced to address the problem of synthesizing the large quantity of information on a particular subject. It is viewed, only as a s…

Recently, 3 different meta-analytic reviews of the literature concerning the effects of extrinsic rewards on intrinsic motivation have appeared, including that by Deci, Koestner, and Ryan (1999) in this issue. Interestingly, despite their common focus, these reviews have offered dramatically opposed bottom-line conclus…

Meta-analysis has seen increasing use as a tool in epidemiology over the past five years. Although this method is relatively well accepted for use in clinical trials, its use has proved somewhat more controversial in epidemiology. If meta-analysis is viewed as an evolutionary improvement over the review article, it may…

To elucidate potential bias sources in meta-analyses, I studied whether the effect of nonsteroidal, anti-inflammatory drugs on joint count in patients with rheumatoid arthritis was related to trial design (active or placebo control), sample size, duration of treatment, drop-out rate, the existence of a wash-in period,…

The research design and methods utilized by the Collaborative Alcohol-Related Longitudinal Project are described. The project design addresses the critical need to develop procedures to assess the replicability of research results in alcohol studies. Key features of the research plan include: re-analysis of original da…

Publication bias may exist when nonsignificant findings remain unpublished, thereby artificially inflating the apparent magnitude of an effect. This concern is not new, but it is particularly current in relation to genetic association studies. Data from a recent meta-analysis of association studies of personality were…

A number of epidemiological studies have addressed the risk of pleural mesothelioma from environmental (household and neighborhood) exposure to asbestos, but no overall risk estimate is available. We reviewed the epidemiological studies on risk of pleural mesothelioma and household or neighborhood exposure to asbestos.…

BACKGOUN: Asthma and dry eye disease are common clinical diseases. Studies have shown that asthma is related to dry eye, but there is no high-quality evidence-based medical evidence. METHOD: This protocol and final study will be conducted in accordance with the Preferred Reporting Items for Systematic review and Meta-…

INTRODUCTION: Accumulating neuroimaging studies have found abnormal cerebral activity in migraine patients. However, the findings of studies exist many differences. Hence, this protocol aims to investigate concurrence across the neuroimaging studies to verify the functional cerebral alterations based on the latest evid…

BACKGROUND: Hematoma expansion (HE) is related to clinical deterioration and unfavorable prognosis in intracerebral hemorrhage (ICH). Some studies have revealed that low serum magnesium level is associated with larger hematoma volume at admission, HE, and unfavorable outcomes. However, the conclusions remain unsettled.…

BACKGROUND: Pulmonary arterial hypertension (PAH) is an incurable disease with high mortality. Although most studies recommend anticoagulation treatment for idiopathic pulmonary arterial hypertension (IPAH), the survival benefits are uncertain. Therefore, the present paper provides a protocol to investigate this issue…

This letter provides a review of the meta-analysis by Rong et al. comparing transperitoneal (TPPN) and retroperitoneal (RPPN) robotic partial nephrectomy. While the study offers valuable insights into perioperative outcomes, such as operating time, hospital stay, blood loss, and complications, there are several methodo…

INTRODUCTION: Postoperative cardiac injury, encompassing myocardial infarction (MI) and myocardial injury after non-cardiac surgery (MINS), is a major perioperative complication associated with substantial morbidity and mortality. While numerous prediction models have been developed using traditional statistical and ma…

INTRODUCTION: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects reproductive-age women, impairing their ability to conceive and sustain fertility. The efficacy of conventional therapies varies among individuals and is often accompanied by multiple side effects. Acupuncture has shown potenti…