2,530 papers found

AIM: The objective of our study is to present a rare case of two eterochronous primary gynaecological malignancies. CASE: A 65-year-old para-2, white obese female, presented in our department 4 years ago, due to a single event of vaginal spotting. Curettage revealed an endometrial cancer. A total abdominal hysterectom…

BACKGROUND: Depression is seen in many cancer patients. It occurs in approximately 25% of palliative care patients. MATERIALS AND METHODS: This study was local, prospective and cross-sectional. It was carried at Department of Clinical Oncology and Radiation Therapy of Charles University Hospital and Faculty of Medicin…

OBJECTIVES: The aim of this study was to present a systematic review of the use of three-dimensional ultrasound for the detection and evaluation of intrauterine device malposition in a patient of our department. BACKGROUND: Transvaginal sonography failed to detect IUD misplacement in about 9% of cases. Whereas the thr…

INTRODUCTION: The contractions of urinary bladder smooth muscle are evoked by parasympathetic nervous system, with its main mediator acetylcholine. These contractions can be inhibited by two basic mechanisms--inhibition of contraction (anticholinergic drugs) or inducing the relaxation (sympathomimetics, calcium channel…

The studies on experimental animals (guinea pigs, monkeys, fish) have confirmed the important role of ascorbic acid deficiency in the development of hypercholesterolemia and atherosclerosis, but the clinical experience is not quite uniform. Metaanalyses of randomized controlled trials performed on subjects without esta…

This review summarizes the current evidence on beneficial effect of statins on the atherogenesis and the preventive potential of coenzyme Q 10 to avoid statin-induced myopathy. Statins, originally discovered in molds are the most effective medication to decrease the low-density cholesterol (LDL-C) which is the key part…

OBJECTIVE: Hepatocyte growth factor (HGF) has been reported the cause of many biological events, including cell proliferation, invasiveness, morphogenesis, and angiogenesis. Elevated HGF content in tumor tissue was reported to predict a more aggressive biology in breast and gastric cancer patients. MATERIALS AND METHO…

This manuscript was in honour of Nobel Prize in chemistry "for the discovery and development of the green fluorescent protein, GFP" to Osamu Shimomura, Martin Chalfie, and Roger Y. Tsien, simultaneously a brief information about experience with GFP in experimental tumorigenesis used this study is also presented. The ex…

In the last 3 years 9 patients with gastrointestinal stromal tumors (GIST) underwent surgery at our department. All cases were with very atypical process. From these patients 3 interesting cases are described in more details. A 75-years-old woman with gastroscopically verified endoluminal tumour in the proximal third o…

Acute otitis media (AOM) is one of the most common infections in children. Recently it was noticed that there is a marked increase in relapse of severe acute otitis media in children. There is also an increase in number of hospitalized children due to severe AOM, with etiological agent resistant to antibiotics. There i…

INTRODUCTION: The diagnosis of chronic hepatitis C is based on serological, biochemical and histological parameters. However, the correlation between the activity of liver enzymes and the degree of histomorphological damage may be very poor. It has been recognised that serum aminotransferase levels do not accurately re…

The aim of this case report was to analyse the efficiency of video-assisted thoracic surgery (VATS) in the treatment of spontaneous pneumothorax. Spontaneous pneumothorax occurs subsequently to a disruption of visceral pleura and escape of air into pleural space. A retrospective study was performed in 5 patients from D…

OBJECTIVES: The authors present their first experience with a new operative method (within two years' period in 18 patients) solving pelvic prolapse in women by means of installation of polypropylene (Prolene) mesh implant. MATERIALS AND METHODS: The authors corrected various forms and stages of POP, particularly prol…

BACKGROUND: The combination of pulmonary valve atresia and ventricular septal defect accounts for about 2% of cases of congenital heart disease. Most of the cases have intracardiac anatomy of Tetralogy Fallot and present with cyanosis in neonatal age. OBJECTIVES: To report a case of a newborn with rare combination of…

In literature, there is paucity of information on the different shapes of styloid processes of the temporal bone of the skull. Textbooks of anatomy describe the styloid process to be slender, approximately 2.5 cm in length and concave on the anterior aspect only. In the present case, we observed the styloid process to…

OBJECTIVES: Determine the outcomes of first rib resection for thoracic outlet syndrome. BACKGROUND: Thoracic Outlet Syndrome is not a very frequent syndrome, affecting especially young patients, predominantly women. Its symptomatology is caused by compression of a nervous and vascular plexuses in a physiological isthm…

We consider identification and inference about mean functionals of observed covariates and an outcome variable subject to non-ignorable missingness. By leveraging a shadow variable, we establish a necessary and sufficient condition for identification of the mean functional even if the full data distribution is not iden…

Current evidence suggests a beneficial role of herbal products in free radical-induced diseases.(Burk.) F. H. Chen has long occupied a leading position in traditional Chinese medicine because of the ergogenic, nootropic, and antistress activities, although these properties are also acknowledged in the Western world. Th…

PURPOSE: We sought to measure quantitative magnetization transfer (qMT) properties of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease (PD) and healthy controls (HCs) using a full qMT analysis and determine whether a rapid single-point measurement yields equivalent results for pool size rat…

BACKGROUND: Novel approaches that complement and go beyond evidence-based medicine are required in the domain of chronic diseases, given the growing incidence of such conditions on the worldwide population. A promising avenue is the secondary use of electronic health records (EHRs), where patient data are analyzed to c…