376,015 papers found

OBJECTIVE: This study performed a network meta-analysis of randomized and matched controlled trials to evaluate the effects of digital interventions on social functioning in children with autism spectrum disorder (ASD), compare the relative efficacy across digital modalities, and generate evidence to inform clinical de…

BackgroundAgitation in Alzheimer's disease significantly impacts patient outcomes and caregiver burden. Brexpiprazole has emerged as a promising treatment option, but optimal dosing remains unclear.ObjectiveTo evaluate the comparative efficacy and safety of different brexpiprazole doses in treating agitation associated…

AIM: Noninvasive neuromodulation techniques, including transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound stimulation (tFUS), are promising interventions for acute treatment of depressive episodes. However, the comparative efficacy and acceptabil…

BACKGROUND: Melasma is a prevalent, persistent hyperpigmentation disorder that negatively affects the psychological health of patients. However, the treatment outcome remains unsatisfactory due to the complexity of pathogenesis, recurrence characteristics, and relatively high morbidity. OBJECTIVES: To compare the perf…

BACKGROUND: Cancer risk has been associated with certain gene variations in microRNA (miRNA), but conflicting evidence warrants re-assessing of significant results in meta-analyses. We summarized published meta-analyses that assess the associations between miRNA polymorphism and cancers to show the validity of the find…

PURPOSE: Long-term effects of ventilatory strategies/adjunctive therapies received in the intensive care unit on mortality of patients with acute respiratory distress syndrome (ARDS) is uncertain. To explore 180-day mortality in adult patients with ARDS, we conducted a network meta-analysis (NMA) comparing the effects…

INTRODUCTION: The aim of the study was to systematically compare the accuracy of artificial intelligence and traditional intraocular lens (IOL) calculation formulas in cataract eyes after vitrectomy with silicone oil tamponade. METHODS: PubMed, Cochrane, Embase, and Web of Science databases were searched to select rel…

BACKGROUND: Therapeutic exercise is the only intervention with strong evidence for fibromyalgia, yet the most effective modality remains uncertain. OBJECTIVE: To determine which modality of therapeutic exercise is the most effective in reducing the impact of fibromyalgia in women, as assessed by the Fibromyalgia Impac…

Elucidating the genetic components of plant genotype-by-environment interactions is of key importance in the context of increasing climatic instability, diversification of agricultural practices and pest pressure due to phytosanitary treatment limitations. The genotypic response to environmental stresses can be investi…

PURPOSE: Meta-analyses are considered to provide level I-II evidence. Based on this premise, several statements have been developed to standardize guidelines and optimize results. The purpose of this study was to investigate the quality of the information delivered by meta-analyses. METHODS: Meta-analyses published in…

The efficacy of fish oil in decreasing restenosis following percutaneous transluminal coronary angioplasty (PTCA) remains controversial despite seven published reports of randomized trials involving 951 patients. We performed a meta-analysis to determine whether these trials, viewed in aggregate, demonstrate a signific…

OBJECTIVE: Insurance companies, legislators, and funding agencies have become increasingly concerned with efficacy and accountability in regard to psychotherapy, and psychodynamic therapy is a primary target of concern because it is widely practiced in outpatient settings. This paper is a meta-analytic review of recent…

This meta-analysis is based on 106 evaluations of response from 77 clinical studies about 5-fluorouracil (5FU) treatment with or without leucovorin (LV) in metastatic colorectal carcinoma. Overall, in naive patients, LV is associated with a median response rate of 31% as compared with a 12% figure with 5FU alone. Using…

In this study all available clinical trials of antibiotic prophylaxis in biliary tract surgery, published from 1965 to 1988, were examined. Results of 42 randomized, controlled trials (4129 patients), in which a group of patients treated with antibiotics was compared with a group of patients not treated with antibiotic…

This review focuses on the results of well-designed studies that have been completed on populations of nuclear workers in the U.S. and the U.K. An attempt is made to introduce a quantitative component to this review, an approach previously described as metaanalysis. Such a method requires designation of eligibility cri…

OBJECTIVE: To examine whether a policy of home visits reduces the amount of antenatal care provided by hospital maternity units. DESIGN: A meta-analysis of three randomized controlled trials. SETTING: 9 maternity units in France. SUBJECTS: 1410 women with pregnancy complications. INTERVENTION: 1 or 2 home visits a…

A meta-analysis was performed on the response times (RTs) of Alzheimer patients and normal subjects for 61 experimental conditions. Regression of the RTs of Alzheimer patients against those of young normals yielded a linear function: Alzheimer (time) = A+B Young (time), where B was a constant proportion of 2.3. As deme…

The efficacy of prophylactic sclerotherapy is unclear because published studies of prophylactic sclerotherapy have reached conflicting conclusions. Meta-analysis was used to determine the efficacy of prophylactic sclerotherapy of esophageal varices. The meta-analysis included all English-language articles reporting res…

The efficacy of azathioprine in the treatment of multiple sclerosis was assessed by meta-analysis of the results of all published blind, randomised, controlled trials. 793 patients were enrolled in 5 double-blind and 2 single-blind studies. After 1 year of treatment, the increase in Kurtzke disability status score was…