381,585 papers found

This review of the literature focuses on risk factors of smoking, hypertension, obesity, and family history that are associated with the development of coronary heart disease. The prevalence of these cardiac risk factors are incorporated from several Canadian health surveys. Health professionals in cardiovascular setti…

Meta-analysis enhances the power of rare variant association tests by combining summary statistics across several cohorts. However, existing methods often fail to control type I error for low-prevalence binary traits and are computationally intensive. Here we introduce Meta-SAIGE-a scalable method for rare varia…

OBJECTIVE: The aim of this study is to perform the first meta-meta-analysis on the effectiveness of parent-based interventions for children with externalizing behavior problems. Even though parent-based interventions are considered as effective treatments the effects reported in meta-analyses are heterogeneous and the…

The "information explosion" in the last 20 years has created a need for technique that synthesizes information from various sources. One of the methods for synthetasing information from various independent but similar studies is meta analysis. The aim of this study was to estimate complication rate of endomyocardial bi…

To demonstrate the advantages of various endoscopic hemostatic methods (laser photocoagulation, electrocautery, injection therapy) for bleeding gastroduodenal ulcer in patients at high risk for continued or recurrent bleeding, a critical review of published randomized clinical trials was made with meta-analytic methods…

The plasma concentration versus antihypertensive effect relationship for the calcium antagonist felodipine was investigated in 67 patients with hypertension and 21 healthy subjects by use of the Emax model. No consistent effect of felodipine on blood pressure was observed in the healthy subjects. In patients with hyper…

This paper reports findings of a subset of 91 programs, which included drug use measures, from the data base previously reported in the author's meta-analysis of 143 adolescent drug prevention programs. Treatment components of strategies successful in decreasing drug use by adolescents are discussed with regard to both…

Meta-analysis on data from 16 (two volunteer and 14 endoscopic) studies ahs been performed to investigate the prevalence of Helicobacter pylori infection in the stomachs of individuals within the Peoples Republic of China. In this survey covering 2216 cases (89 volunteers and 2127 endoscopy patients), the incidence of…

Tissue factor pathway inhibitor (TFPI) impedes early stages of the blood coagulation response, and low TFPI plasma levels increase the risk of thrombosis. TFPI plasma levels are heritable, but specific genetic determinants are unclear. We conducted a comprehensive review of genetic risk factors for TFPI plasma levels a…

PURPOSE: Physical activity (PA) is important for the prevention and management of cardiovascular (CV) disease (CVD). We aim to investigate the effect of different types of exercise on cardiometabolic risk factors in these subjects with CV risk factors but no history of CVD is lacking. METHODS: PubMed and Scopus databa…

BACKGROUND: Colorectal cancer survivors frequently experience persistent fatigue, psychological distress, and reduced health-related quality of life (HRQoL) after treatment. Exercise is increasingly recognized as an effective nonpharmacologic intervention, but the comparative efficacy of different modalities remains un…

BACKGROUND: Chronic low back pain (CLBP) is a prevalent musculoskeletal disorder. Electrotherapy modalities such as high-frequency transcutaneous electrical nerve stimulation (HF-TENS), low-frequency transcutaneous electrical nerve stimulation (LF-TENS), and interferential current (IFC) are commonly used, yet their com…

OBJECTIVE: Considering safety and effectiveness of oral antihypertensive agents when treating hypertensive disorders of pregnancy, no preference can be stated between the 3 agents currently available. Therefore, this systematic review and network meta-analysis aims to determine the effects of antenatal treatment with m…

Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor grow…

The role of the addition of anti-androgen therapy to surgical or chemical castration in metastatic prostate cancer is still unclear. The impact on time to progression and mortality of this treatment modality is, however, likely to be moderate at most. Is this therapeutic approach of real benefit? A reliable answer to t…

A review of the literature dealing with the relationship between coffee consumption and coronary heart disease revealed that most of the studies did not find coffee consumption to be a risk factor. However, many studies are plagued with methodological difficulties which operate to minimize the probability of identifyin…

80 reports of randomised clinical trials in four leading general medical journals were reviewed. The reporting of the methodology of randomisation was inadequate. In 30% of trials there was no clear evidence that the groups had been randomised. Among trials that used simple randomisation the sample sizes in the two gro…

CONTEXT: Neuromuscular training (NMT) enhances balance among recreational athletes, but the effectiveness of single- versus multicomponent NMT remains unclear. OBJECTIVE: To compare the effectiveness of single- and multicomponent NMT on balance performance among recreational athletes and explore the influence of age,…

Venous thromboembolism (VTE), including deep vein thrombosis (DVT), and pulmonary embolism (PE), is a common complication in patients with ischemic stroke. Several prophylactic strategies are used to reduce the risk of VTE. However, there is still a lack of consensus on the optimal strategy due to the lack of randomize…