44,621 papers found

BACKGROUND AND PURPOSE: Opioids are potent analgesics. Opioids exert effects after interaction with opioid receptors. Opioid receptors are present in the peripheral- and central nervous system (CNS), but the analgesic effects are primarily mediated via receptors in the CNS. Objective methods for assessment of opioid ef…

BACKGROUND: Transdermal scopolamine (TDS) is a potential long-acting prophylactic antiemetic initially developed to prevent motion sickness. TDS is a centrally acting anticholinergic agent that was approved in 2001 by the US Food and Drug Administration for the prevention of postoperative nausea and vomiting (PONV). Al…

It is with great pleasure and proud that we can announce that Diagnostics is now indexed and searchable in PubMed.[...].

BACKGROUND: While several publications have focused on the intuitive role of augmented reality (AR) and virtual reality (VR) in neurosurgical planning, the aim of this review was to explore other avenues, where these technologies have significant utility and applicability. METHODS: This review was conducted by searchi…

OBJECTIVE: By analyzing high readership articles from the() in the PubMed Central (PMC) database, this study aims to identify research hotspots and trends in the field of pediatrics. METHODS: Articles from theranked by annual readership in PMC from 2021 to 2023 were collected. Using word frequency analysis and co-word…

BACKGROUND: This study aimed to evaluate the clinical efficacy of Chinese medicine for the treatment of centrally mediated abdominal pain syndrome (CAPS) using a meta-analysis system. METHODS: Six databases, including China National Knowledge Infrastructure, Vendor Information Pages, Chinese Biomedical Database, Wanfa…

INTRODUCTION: Liposarcoma of the bone is an extremely rare and aggressive primary bone tumor. We aimed to review all liposarcoma cases in the literature and present our new young female patient with liposarcoma. METHODS: of literature review and case presentation: Electronic databases (PubMed, Scopus, Web of Science (…

INTRODUCTION: The National Library of Medicine (NLM) launched a Pilot in June 2020 to: 1) explore the feasibility and utility of adding preprints to PubMed Central (PMC) and making them discoverable in PubMed, and 2) to support accelerated discoverability of National Institutes of Health (NIH)-supported research withou…

This PDF receipt will only be used as the basis for generating PubMed Central (PMC) documents. PMC documents will be made available for review after conversion (approx. 2-3 weeks time). Any corrections that need to be made will be done at that time. No materials will be released to PMC without the approval of an author…

BACKGROUND: Jupyter notebooks facilitate the bundling of executable code with its documentation and output in one interactive environment, and they represent a popular mechanism to document and share computational workflows, including for research publications. The reproducibility of computational aspects of research i…

The multidrug resistance P-glycoprotein (P-gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This poly-specificity is imparted by at least four pharmacologically distinct binding sites within the transmembrane domain. Whether or not these sites are spatially distinct has remain…

Viral infections of the central nervous system such as meningitis, encephalitis or meningoencephalitis, are important causes of significant morbidities and mortality worldwide. Early diagnosis and prompt treatment will lead to better outcomes, but any delay may results in high fatality with serious neurologic sequelae…