44,713 papers found

BACKGROUND: Virtual reality (VR) technologies are increasingly applied in neurorehabilitation, but most research has focused on their therapeutic applications rather than assessment potential. OBJECTIVE: The aim of this scoping review was to map the evidence on VR-based assessment tools in neurorehabilitation, includin…

Spinal cord injury and traumatic brain injury result in significant functional loss and neurological deficits. Since the central nervous system in mammals has limited regeneration ability, treatment options are limited. To advance understanding of the molecular and cellular mechanisms underlying CNS injury and repair,…

PURPOSE: To review cadaveric studies evaluating the maximum load to failure after proximal hamstring repair with various numbers and sizes of anchors. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used when conducting this systematic review. PubMed, Cochrane C…

INTRODUCTION: Stabilisation splint therapy (SST) is one of the treatment options for patients with temporomandibular disorder (TMD) and has strong evidence supporting its benefits. However, there is still limited scientific understanding of the unintended consequences of SST that may lead to alterations of the surround…

BACKGROUND: The macula is located at the center of the retina and is crucial for high-resolution color vision. Its complex anatomical structure supports a dense array of cone photoreceptors and specialized neuronal pathways essential for central vision. A thorough understanding of macular microanatomy is vital for accu…

Incisional hernia is a common surgical complication that often requires mesh-based repair. Among the various techniques, sublay (retrorectus) and onlay mesh placements are frequently employed, but their relative effectiveness in terms of surgical outcomes remains debated. This meta-analysis aimed to compare sublay and…

OBJECTIVE: To analyze the effectiveness of intrathecal baclofen in the treatment of spasticity of different aetiologies in the upper limbs, lower limbs, and both children and adults. DESIGN: Meta-analysis. SUBJECTS/PATIENTS: People with spasticity of different aetiologies in treatment with intrathecal baclofen. METH…

Osteoarthritis (OA) is a prevalent condition that significantly impacts the quality of life due to pain and associated disability. Platelet-rich plasma (PRP) injections have emerged as a promising alternative treatment, though their efficacy and safety remain debatable. This systematic review aims to evaluate the…

OBJECTIVES: Patients with fibromyalgia syndrome (FM) often suffer from sleep disorders, adversely affecting their prognosis. Active non-pharmacological therapies are considered the mainstay of treatment for FM, but the optimal treatment choice remains contentious. We aimed to compare and rank community-based non-pharma…

A substantial number of patients with intracranial dural arteriovenous fistula (dAVF) suffer from coexistent cerebral venous sinus thrombosis (CVST), yet this clinical relation is poorly studied. We aim to study the clinical and radiological outcome of patients with coexistent dAVF and CVST based on different treatment…

Major advances have been made in obesity treatment, focusing on restoring disturbances along the gut-brain axis. The endocannabinoid system (ECS) is a neuromodulatory signaling system, present along the entire gut-brain axis, that plays a critical role in central and peripheral regulation of food intake and body weight…

OBJECTIVE: This work aims to examine the latest evidence on the impact of pre-biopsy MRI, in addition to prostate-specific antigen (PSA) testing, on health outcomes and quality of life. METHODS: We conducted a literature search including PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) databases, wi…

BACKGROUND: Functional gastrointestinal disorders (FGIDs) are closely related to disorders of brain-gut interaction. FGIDs are the dominant disease of acupuncture treatment, which can improve the symptoms and emotional state. AIM: To evaluate the results and quality of the available clinical evidence and to summarize…

The utilization of negative pressure wound therapy (NPWT) in lowering the incidence of infections in closed colorectal surgical incisions has not been thoroughly established, and recent trials have had conflicting results. This meta-analysis was conducted to synthesize the findings of available trial data and carefully…

INTRODUCTION: Spinal cord injury (SCI) is a significant and transforming event, with an estimated annual incidence of 40 cases per million individuals in North America. Considering the significance of accurate diagnosis and effective therapy in managing SCI, Machine Learning (ML) and Robot-Assisted Gait Training (RAGT)…

PURPOSE: The aim of this review was to compare the currently available root canal filling materials for primary teeth to zinc oxide eugenol (ZOE) to find a suitable alternative. The search question was: which root canal filling materials used in pulpectomy for primary teeth give better clinical and radiograph…

One of the common challenges in oral surgery is dealing with patients who are taking oral anticoagulant/antiaggregant drugs. Several local hemostatic agents have been proposed as an alternative to conventional suturing. Among these, autologous platelet concentrates (APCs) have been widely used to decrease the risk of h…

BACKGROUND: Pets offer significant health benefits, from decreased cardiovascular risks to anxiety and post-traumatic stress improvements. Animal-assisted interventions (AAI) are not frequently practiced in the intensive care unit (ICU) for fear of health risk for critical patients because there is a hypothetical risk…

Irritable bowel syndrome is a typical gastrointestinal disease that causes bloating, flatulence, abdominal pain, diarrhoea, constipation, or alteration of the last two in adults and children. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is one of the potential treatme…

BACKGROUND: Bariatric surgery has been reported to improve degeneration, inflammation, and fibrosis in nonalcoholic fatty liver disease, but the effects of bariatric surgery on the associated clinical outcomes is not known. OBJECTIVES: This work aimed to assess the impacts of bariatric surgery on adverse liver outcome…