42,398 papers found

BACKGROUND AND OBJECTIVE: Malignant grade and death rate are very high for non-small cell lung cancer, and gefitinib is a new molecule target anticancer drug. The aim of this meta analysis is to evaluate the clinical efficacy and safety of gefitinib for non-small cell lung cancer. METHODS: We searched the Cochrane Cen…

There is evidence from animal studies that repeated exposure to methylphenidate (MPH), a widely used psychostimulant for the treatment of attention deficit hyperactivity disorder (ADHD), produces behavioural, structural and neurochemical changes that persist long after drug administration has ended. However, the transl…

BACKGROUND: Synchronized ventilation of neonates is standard care in industrialized countries. Both flow-cycled and time-cycled modes of synchronized ventilation are in widespread use for assisted ventilation of neonates. OBJECTIVES: To determine the effect of flow-cycled versus time-cycled synchronized ventilation on…

AIMS: The escalating global prevalence of childhood and adolescent overweight and obesity constitutes a pressing public health issue. This network meta-analysis aimed to compare the efficacy and safety of pharmacologic interventions as adjuncts to lifestyle therapy in this population. MATERIALS AND METHODS: Randomized…

PURPOSE: This study systematically reviewed the fatigue mechanisms that constrain trail running performance and examined the influence of sex and event distance on these responses. PRISMA guidelines were followed. PubMed, Web of Science, and Dimensions AI databases were searched up to August 10, 2025 for studies involv…

BACKGROUND: Inhibitory control is a key component of executive function, influencing academic achievement, behavior, and long-term outcomes in children and adolescents. Physical activity (PA) has been identified as a potential intervention to improve inhibitory control, but the optimal type and dosage remain uncertain.…

BACKGROUND AND AIMS: The use of supraglottic airway devices (SGADs) is still controversial in paediatric otorhinolaryngological surgeries. We conducted this review and analysis to compare SGADs to endotracheal tubes (ETTs) regarding the feasibility of their use in children. METHODS: Randomised controlled trials (RCTs)…

OBJECTIVES: To evaluate the long-term clinical efficacy of dentin desensitizing agents with mechanisms of action by tubular occlusion, neural effect or both, for the treatment of dentin hypersensitivity (DH). DATA AND SOURCES: Following electronic databases: Pubmed (MEDLINE), Cochrane Central Register of Controlled Tr…

BACKGROUND: In this study, we aim to evaluate the effects of hyaluronic acid and its derivatives on wound healing in diabetic foot ulcer. METHODS: The electronic databases included PubMed, BIOSIS, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar internet. The final search was update…

BACKGROUND: Tibial eminence fractures are common injuries that can cause significant functional limitations and require timely and effective treatment. Arthroscopic screw fixation and suture fixation are the primary methods used for managing displaced fractures. This study aimed to compare the functional and clinical o…

Left ventricular thrombus (LVT) is a serious complication associated with myocardial infarction and cardiomyopathy. While vitamin K antagonists (VKAs) have been the standard treatment, direct oral anticoagulants (DOACs) offer potential advantages. This meta-analysis compares the efficacy and safety of DOACs versus VKAs…

INTRODUCTION: The reported incidence of pediatric facial fractures is relatively low, within age limits of up to 5 years, whereas prevalence increases in children and adolescents. Considering the active growth that takes place in children, maxillofacial trauma can have deleterious effects if it involves growth cen…

Pulmonary hypertension (PH) is associated with the outcomes of mitral valve transcatheter edge-to-edge repair (M-TEER) in patients with severe mitral regurgitation (MR). However, the prognosis of baseline PH on MR patients after M-TEER has been controversial. This meta-analysis aimed to determine the prognostic value o…

BACKGROUND: To determine and review the currently available literature behind the staging capabilities of 18F-PSMA-1007 PET/CT in the setting of initial staging and detection of recurrent disease for patients with prostate cancer. Prostate cancer (PCa), one of the most diagnosed malignancies affecting adult men worldwi…

Effects of sleep on procedural (implicit) memory consolidation in children remain controversial. The aim of this systematic review was to synthesise the evidence on the influence of sleep on motor skills acquisition in children. Four electronic databases were searched: PubMed, Cochrane Central Register of Controlled Tr…

BACKGROUND: Considerable interindividual variability for the pharmacokinetics of caffeine in preterm infants has been demonstrated, emphasizing the importance of personalized dosing. This study aimed to develop and apply a repository of currently published population pharmacokinetic (PopPK) models of caffeine in preter…

Herbal medicine is widely used for dermatological diseases, particularly atopic dermatitis. This study aims to systematically review existing literature on the efficacy of both topical and systemic herbal interventions for atopic dermatitis across various age groups. Conducting a comprehensive search on MEDLINE/PubMed,…

INTRODUCTION: Alcoholic liver disease (ALD) encompasses a spectrum of liver conditions, including liver steatosis, alcoholic hepatitis (AH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). microRNAs (miRNAs) have garnered significant interest as potential biomarkers for ALD. METHODS: We searched PubMed, Embas…

Several studies have indicated that miRNAs play crucial roles in adipogenesis, insulin resistance, and inflammatory pathways associated with obesity and change after metabolic bariatric surgery (MBS). This systematic review explores and maps the existing literature on how miRNAs are expressed and investigates the uniqu…

OBJECTIVE: The aim of this study was to evaluate the amount of external apical root resorption in patients who had undergone orthodontic treatment with clear aligners evaluated using cone beam computed tomography. METHODS: Studies that evaluated external apical root resorption before and after comprehensive orthodonti…