376,015 papers found

It is hypothesized that in depressed patients diurnal variation in mood (DV) is a daily recurring phenomenon, which fails to achieve expression on all days (showing a random distribution of DVs). From this perspective a meta-analysis was performed on the raw data of earlier presented studies. The effect of total sleep…

To compare radiotherapy alone to chemotherapy plus radiotherapy in the treatment of early stage Hodgkin's disease, the English language medical literature was searched for reports on randomized clinical trials in Stages I and II Hodgkin's disease from 1975 through 1986. Twenty-three reports with 2999 patients were ente…

Network Meta-analysis was conducted to evaluate the efficacy and safety of different TCM injections combined with conventional western medicine in the treatment of viral pneumonia. A comprehensive computerized search was performed in CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science, EMbase, and Cochrane Library. The…

BACKGROUND: Optimal antithrombotic management for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) or coronary artery disease (CAD) remains challenging because bleeding and ischemic risks compete. We compared five strategies: de-escalation (sho…

BACKGROUND: Although single-agent chemotherapy is the most common approach for treating platinum-resistant or refractory ovarian cancer (PROC), there is growing evidence that combining molecular targeted agents with chemotherapy is beneficial, especially for certain patient groups. However, the most effective combinati…

BACKGROUND: Thyrotoxicosis refers to a condition where there is an excess of thyroid hormone production by the thyroid gland itself, leading to a form of hyperthyroidism. OBJECTIVE: This study is based on systematic review and network meta-analysis methods, aiming to provide a more reliable basis for the selection of…

OBJECTIVE: Executive function (EF) is a critical component of healthy aging, and its decline represents a fundamental challenge to neurological health. This network meta-analysis (NMA) systematically compared and ranked the effects of a spectrum of non-pharmacological interventions on overall EF and its key subdomains-…

BACKGROUND: Vestibular migraine causes recurrent vertigo attacks that significantly impact quality of life. While various preventive medications are used, their comparative effectiveness was unknown. Previous systematic reviews have been limited by pairwise comparisons only or exclusion of newer treatments. The lack of…

OBJECTIVES: This study aimed to compare the impacts of different nutritional supplements and drugs on older adults with sarcopenia. DESIGN: Systematic review and network meta-analysis. SETTING AND PARTICIPANTS: Participants with sarcopenia receiving nutritional and pharmacological interventions targeting sarcopenia i…

OBJECTIVES: Optimizing chest drainage management after lung cancer surgery plays a pivotal role in minimizing drainage time and shortening length of hospital stay (LOHS). Currently, a universally acceptable standard is lacking, and a wide range of drain management strategies are practiced. Therefore, the aim of this sy…

The study aimed to compare the efficacy and safety of netarsudil (NET), alone or in fixed-dose combinations (FDC), in comparison with prostaglandin analogues (PGAs: bimatoprost [BIM], latanoprost [LAT], travoprost [TRA], and tafluprost [TAF]) for the treatment of primary open-angle glaucoma (POAG) or ocular hypertensio…

OBJECTIVES: This economic evaluation aimed to identify a cost-effective first-line treatment for unresectable hepatocellular carcinoma (uHCC) within China's healthcare system, specifically focusing on immune checkpoint inhibitor (ICI)-based regimens relevant to clinical practice, including newly approved options. METH…

OBJECTIVE: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of different interventions in preventing gestational hypertension (GHT). METHODS: A comprehensive search of English databases was performed from database inception to March 1st, 2025 to identify randomized…

BACKGROUND: Surgical site infection (SSI) is one of the most frequent complications after stoma closure. It is associated with prolonged recovery, increased healthcare costs and impaired quality of life. Several skin closure techniques have been proposed to reduce SSI. However, most previous studies relied on pairwise…

BackgroundCerebral venous thrombosis (CVT) is a rare but severe type of stroke, typically treated with vitamin K antagonists (VKAs). This study compares different direct oral anticoagulants (DOACs) with VKAs for the management of CVT.MethodsPubMed, Cochrane Central, and ScienceDirect were searched up to May 2025. A net…

BACKGROUND: Hypertensive disorders of pregnancy (HDP), including gestational hypertension (GH) and preeclampsia (PE), are common pregnancy complications with potential long-term cardiovascular consequences. Evidence suggests an association between HDP and future cardiomyopathy, including dilated cardiomyopathy. OBJECT…

OBJECTIVES: To evaluate the accuracy of static, dynamic, and robotic computer-assisted protocols in immediate implant placement (IIP), compared to freehand (FH) techniques. MATERIALS AND METHODS: A systematic search was conducted for studies published through March 2025. Clinical studies on Computer-Aided Implant Surg…

AIM: This network meta-analysis of randomized controlled trials (RCTs) aimed to investigate which hypnotics are associated with the most favorable sleep architecture and respiratory outcomes in adults with obstructive sleep apnea. METHODS: Primary outcomes included total sleep time (TST) and apnea-hypopnea index (AHI)…

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent adverse effect linked to neurotoxic chemotherapeutic agents. Current pharmacological treatments exhibit limited efficacy and notable adverse effects. The clinical effectiveness of non-pharmacological therapies, like acupuncture, physical exerc…