44,707 papers found

Occlusal splints are widely used as a conservative treatment modality for temporomandibular disorders (TMD). With the increasing integration of digital technologies in dentistry, computer-aided design and manufacturing (CAD/CAM) workflows have emerged. Although digital splints are increasingly adopted in clinical pract…

Boron neutron capture therapy (BNCT) is a biologically targeted, high-linear energy transfer radiotherapy that selectively delivers cytotoxic α-particles to boron-loaded tumor cells and has re-emerged with the development of hospital-compatible accelerator neutron sources and improved boron carriers. We performed…

PURPOSE: To systematically review the anatomical and functional outcomes of vitreoretinal surgery for familial exudative vitreoretinopathy (FEVR)-associated retinal detachment (RD). METHODS: A systematic review and meta-analysis were conducted following a PROSPERO-registered protocol. The Cochrane Central Register of…

BACKGROUND: Giant cell arteritis (GCA) is a chronic inflammatory vasculopathy associated with an increased risk of cardiovascular and thromboembolic complications, including acute coronary syndrome (ACS). Early identification of high-risk subgroups is essential for targeted prevention. This scoping review summarizes th…

BACKGROUND: Hemodialysis is a common renal replacement therapy for patients with end-stage renal disease (ESRD). The common types of vascular access mainly include arteriovenous fistula (AVF), arteriovenous graft (AVG), and central venous catheter (CVC). However, the association between different access types and all-c…

OBJECTIVE: To perform a systematic review of the effect of preoperative teaching methods on outcomes for adult patients undergoing major head and neck surgery. DATA SOURCES: OVID Medline, CINAHL, Cochrane, Pubmed, and Embase databases were queried. REVIEW METHODS: A comprehensive literature search was conducted in Ja…

OBJECTIVE: This study aimed to summarize and analyze the current literature related to calcitonin gene-related peptide (CGRP), the vestibular system, and vestibular migraine. BACKGROUND: CGRP is a neuropeptide that has been implicated in the pathophysiology of migraine. Vestibular migraine (VM) is a subtype of migrain…

BACKGROUND: We performed this meta-analysis to evaluate the effects of effectiveness of silver-based dressings for the treatment of diabetic foot ulcer (DFU). METHODS: In the study, we searched electronic databases including PubMed, EMBASE, BIOSIS, Web of Science, Cochrane Central Register of Controlled Trials (CENTRA…

We evaluated the effect of phacoemulsification on intraocular pressure (IOP) and the reduction of glaucoma medications in patients with glaucoma. Our protocol was registered in PROSPERO (CRD42024533437). We conducted a systematic search in PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), and We…

BACKGROUND: Dysfunctional glutamatergic neurotransmission has been implicated in the underlying pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD). The psychostimulant methylphenidate (MPH), which is used as a first line treatment for ADHD, has been shown to have both acute and chronic effects on prefronta…

INTRODUCTION: Brain and spine metastases are a major cause of morbidity and mortality in patients with malignancy. Aside from advancements in medical, surgical, and radiation therapies, patient workflow optimization augments care. Here, we present the first systematic review to identify opportunities in workflow optimi…

Evidence linking diet and ocular diseases is growing, yet variations persist, with a paucity of data in sub-Saharan Africa. The proposed review will systematically synthesize evidence on dietary factors associated with predominant eye disorders (cataracts, refractive error, glaucoma, diabetic retinopathy, age-related m…

The COVID-19 global pandemic affected every human on earth, and we are still currently feeling the repercussions. The unprecedented transmission of the virus and the response as well as the mobilization of the major health authorities internationally resulted in one of the largest-scale immunization drives in modern hi…

High-flow nasal oxygen therapy (HFNO) is highly versatile and employed in varied situations, including after extubation, in cases of respiratory failure, and at the end of life. However, its impact on swallowing function is not yet elucidated. Therefore, this scoping review aimed to clarify how HFNO affects swallowing…

Mindfulness-based interventions have been receiving growing attention in cancer care. This study was performed to determine the effect of a mindfulness-based stress reduction program on depression and quality of life in cancer patients. The screenings in the study were performed in January to May 2023 through the Cochr…

Alendronate, a second-generation bisphosphonate, remains the first-line therapeutic option for postmenopausal osteoporosis. It acts on the bone resorbing osteoclasts causing their apoptosis. This is achieved by producing toxic adenosine triphosphate (ATP) analogues and interfering with the mevalonate pathway. Teriparat…

AIM: This systematic review and meta-analysis was undertaken to identify the risk factors of long coronavirus disease 2019 (COVID-19) to provide insight for selecting cases for more aggressive monitoring and treatment after COVID-19 infection and reduce morbidity due to long COVID-19. MATERIALS AND METHODS: All releva…

AIM: We conducted a meta-analysis comparing the invasiveness of automatic lancet devices, which can collect adequate amount of blood at shallow puncture depths, with conventional manual lance devices (lancet or needle) to statistically identify less invasive instruments for neonatal heel lance. METHODS: We searched Pu…

Evidence for reducing cardiovascular and renal events with sotagliflozin is uncertain among type 2 diabetes mellitus (T2DM) patients. To gather more evidence, this meta-analysis assesses the beneficial effects of sotagliflozin, a dual sodium-glucose cotransporter 1 and 2 inhibitor, in reducing the cardiovascular and re…

OBJECTIVE: To critically appraise and assess the currently observed evidence about the difference in orthodontic treatment duration between clear aligners and fixed appliances in crowding cases. MATERIALS AND METHODS: An electronic search without limitations was conducted from inception to June 2023 covering nine data…