382,193 papers found

The exponential growth of secondary literature has created an imperative for researchers to identify credible and methodologically sound studies within an increasingly complex information landscape. In light of the growing emphasis on evidence-based medicine in both domestic and international contexts, umbrella reviews…

Often both aggregate data (AD) studies and individual participant data (IPD) studies are available for specific treatments. Combining these two sources of data could improve the overall meta-analytic estimates of treatment effects. Moreover, often for some studies with AD, the associated IPD maybe available, albeit at…

OBJECTIVE: The connection between personality traits and performance has fascinated scholars in a variety of disciplines for over a century. The present research synthesizes results from 54 meta-analyses (k = 2028, N = 554,778) to examine the association of Big Five traits with overall performance.…

To extend use of the recently described 'likelihood to be diagnosed or misdiagnosed' (LDM) metric for test accuracy studies through application to recent meta-analytic data of commonly used cognitive screening instruments.Raw data (true positives and negatives, false positives and negatives) were extracted from meta-an…

Although many researchers have discussed replication as a means to facilitate self-correcting science, in this article, we identify meta-analyses and evaluating the validity of correlational and causal inferences as additional processes crucial to self-correction. We argue that researchers have a duty to describe sampl…

In this commentary, we add to the spirit of the articles appearing in the special series devoted to meta- and statistical analysis of single-case intervention-design data. Following a brief discussion of historical factors leading to our initial involvement in statistical analysis of such data, we discuss: (a) the valu…

BACKGROUND: Hearing loss is one of the leading causes of disability worldwide, with greater than 20% of Canadian adults having measurable hearing loss in at least one ear. Patients with hearing loss experience impaired quality of life, and emotional and financial consequences that affect themselves and their families.…

Neurosurgeons are inundated with the Herculean task to keep abreast with the rapid pace at which clinical research is proliferating. Systematic reviews and meta-analyses (SRMAs) have consequently surged in popularity because when executed properly, they constitute the highest level of evidence, and may save busy neuros…

Systematic reviews (SRs) are a form of research methodology that addresses a specific research question by collecting, appraising and summarising all empirical evidence that fits pre-specified eligibility criteria. Systematic reviews have grown exponentially since their emergence in the late 1970 s as evidence-b…

The Cochrane risk of bias tool (RoB) is a widely used measure for methodological quality of randomized controlled trials. This paper discusses RoB's rationale and risk of bias domains, reports on its application in current psychotherapy meta-analyses, and offers comments regarding the application of RoB in the context…

The analysis of count data is commonly done using Poisson models. Negative binomial models are a straightforward and readily motivated generalization for the case of overdispersed data, that is, when the observed variance is greater than expected under a Poissonian model. Rate and overdispersion parameters then need to…

Cell migration research has recently become both a high content and a high throughput field thanks to technological, computational, and methodological advances. Simultaneously, however, urgent bioinformatics needs regarding data management, standardization, and dissemination have emerged. To address these concerns, we…