42,378 papers found

This network meta-analysis was conducted to obtain the relative effectiveness of different pharmacotherapy of macular edema secondary to retinal vein occlusion (RVO) by summarizing all available evidences.PubMed, Embase, and Cochrane Library databases were searched for all relevant randomized controlled trials. The out…

BACKGROUND AND OBJECTIVES: To facilitate and improve the diagnostic and therapeutic process by systematically reviewing studies on patients with primary angiitis of the CNS (PACNS). METHODS: We searched PubMed, looking at the period between 1988 and February 2020. Studies with adult patients with PACNS were included.…

BACKGROUND: Percutaneous catheterization is a frequently-used technique to gain access to the central venous circulation. Inadvertent arterial puncture is often without consequence, but can lead to devastating complications if it goes unrecognized and a large-bore dilator or catheter is inserted. The present study revi…

BACKGROUND: Suspicion of a CNS tumour is classically raised by symptoms of raised intracranial pressure, focal deficits (including seizures), or papilloedema. Development of guidelines is needed for the identification and referral of children who might have a CNS tumour. We did a systematic literature review and meta-a…

BACKGROUND AND OBJECTIVE: Chronic low back pain (CLBP) is clinically heterogeneous and generates substantial symptom burden, functional limitation, psychological distress, work disability, and health-care utilization. Existing phenotyping approaches often describe subgroups but do not specify how subgroup assignment ch…

BACKGROUND: Cannabidiol (CBD) has emerged as a promising adjunctive therapy for drug-resistant epilepsy, yet clinical findings remain heterogeneous across trials. This meta-analysis aimed to evaluate the efficacy, safety, and formulation-dependent performance of CBD in patients with treatment-resistant epilepsies. MET…

INTRODUCTION: Energy drinks are widely marketed to enhance alertness and performance, making them a rapidly growing industry valued at $73.99 billion. These beverages typically contain caffeine and other stimulants, but their consumption has raised concerns about potential cardiovascular risks, including arrhythmi…

INTRODUCTION: This review aims to systematically investigate the existing research on the effects of anthocyanins on cognitive functions and their underlying mechanisms involved. It provides detailed insights into their development and potential applications. METHOD: An extensive review and analysis of various animal…

The objective of this study is to compare the pathological complete response (pCR) and survival rates of different neoadjuvant chemoradiotherapy modalities (NACRT) for locally advanced rectal cancer, which is defined as rectal cancer with T3-4/N + and without distant metastasis. We searched PubMed, Web of…

Allergic rhinitis (AR) affects millions of people worldwide, impacting quality of life and causing economic burden. Intranasal corticosteroids (INCs) are the mainstay treatment for AR, delivered via aerosol or aqueous sprays.This systematic review and meta-analysis investigate the comparative efficacy and safety of aer…

BACKGROUND: Thymectomy is indicated in the presence of primary thymic diseases such as thymoma. However, there is no clear conclusion which is the best surgical approach for thymectomy. We performed this network meta-analysis (NMA) to compare the outcomes of different surgical approaches for thymectomy. METHODS: An ex…

BACKGROUND: This systematic review and meta-analysis is an update to prior research to evaluate the effects of yoga for managing prehypertension and hypertension. METHODS: Medline/PubMed, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from their inception until April 5th 2024. Ra…

Dupilumab, a monoclonal antibody, acts as a dual-action inhibitor that effectively suppresses interleukin-4 (IL-4) and interleukin-13 (IL-13) secretion, which plays an important role in type 2 inflammation. Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin disorder that affects both adults an…

BACKGROUND: Fatigue is commonly experienced amongst persons with multiple sclerosis (PwMS), decreasing quality of life and increasing the economic burden of care. Several pharmacologic treatments have been studied in randomized clinical trials (RCTs) for fatigue in MS, with conflicting results. METHODS: We performed a…

INTRODUCTION: Aedes-borne arboviral infections, both imported and autochthonous, are reported in Europe. We evaluated the landscape of these infections in Europe over 23 years and attempted to pre-empt the trajectory of impact of these infections in the climatic context of Aedes mosquito expansion in Europe. METHODS:…

BACKGROUND: Pulmonary embolism (PE) survivors frequently experience persistent dyspnea and diminished quality of life (QoL). Evidence suggests that rehabilitation exercise has a positive impact on QoL, physical fitness, and dyspnea in patients with heart disease and chronic obstructive pulmonary disease. However, the e…

Nonalcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic liver disease (MASLD), is a common chronic liver condition characterized by hepatic steatosis and inflammation, with an increased risk of developing fibrosis and cirrhosis. This systematic review aims to evaluate…

The aim of this paper is to summarize the available evidence in the literature regarding the effects generated by exposure to an enriched environment (EE) on the modulation of epigenetic processes in the central nervous system under adverse environmental conditions. Searches were conducted in three databases: PubMed/Me…

BACKGROUND: Pancreaticoduodenectomy is a complex intra-abdominal operation used for the treatment of benign and malignant disease of the pancreatic head or periampullary region. Despite developments in surgical techniques, pancreaticoduodenectomy is still associated with high rate of postoperative complications. We per…

INTRODUCTION: Armodafinil is a psychostimulant that promotes alertness, and it has been shown to improve attention, memory, and fatigue in healthy adults and adults with neurodevelopmental conditions that share symptoms with Attention Deficit Hyperactivity Disorder (ADHD). It is generally well tolerated and safe, and m…