42,378 papers found

BACKGROUND: Older individuals experience physiologic changes in organ function related to aging or to specific disease processes. These changes can affect drug pharmacodynamics in older adults. OBJECTIVE: The goal of this article was to review age-related changes in pharmacodynamics and their clinical relevance. METH…

BACKGROUND: The cardiovascular safety of testosterone replacement therapy (TRT) in older men with hypogonadism has been debated for over a decade, largely on the basis of underpowered trials and conflicting observational data. The TRAVERSE trial, published in 2023, provided the first adequately powered, placebo-control…

() infection has been extensively studied for its potential association with irritable bowel syndrome (IBS), with prior meta-analyses reporting inconsistent findings. This study aimed to perform a systematic review and meta-analysis of observational studies restricted to those providing reconstructable 2×2 conting…

Occlusal splints are widely used as a conservative treatment modality for temporomandibular disorders (TMD). With the increasing integration of digital technologies in dentistry, computer-aided design and manufacturing (CAD/CAM) workflows have emerged. Although digital splints are increasingly adopted in clinical pract…

Boron neutron capture therapy (BNCT) is a biologically targeted, high-linear energy transfer radiotherapy that selectively delivers cytotoxic α-particles to boron-loaded tumor cells and has re-emerged with the development of hospital-compatible accelerator neutron sources and improved boron carriers. We performed…

PURPOSE: To systematically review the anatomical and functional outcomes of vitreoretinal surgery for familial exudative vitreoretinopathy (FEVR)-associated retinal detachment (RD). METHODS: A systematic review and meta-analysis were conducted following a PROSPERO-registered protocol. The Cochrane Central Register of…

BACKGROUND: Giant cell arteritis (GCA) is a chronic inflammatory vasculopathy associated with an increased risk of cardiovascular and thromboembolic complications, including acute coronary syndrome (ACS). Early identification of high-risk subgroups is essential for targeted prevention. This scoping review summarizes th…

BACKGROUND: Hemodialysis is a common renal replacement therapy for patients with end-stage renal disease (ESRD). The common types of vascular access mainly include arteriovenous fistula (AVF), arteriovenous graft (AVG), and central venous catheter (CVC). However, the association between different access types and all-c…

BACKGROUND: Dysfunctional glutamatergic neurotransmission has been implicated in the underlying pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD). The psychostimulant methylphenidate (MPH), which is used as a first line treatment for ADHD, has been shown to have both acute and chronic effects on prefronta…

The COVID-19 global pandemic affected every human on earth, and we are still currently feeling the repercussions. The unprecedented transmission of the virus and the response as well as the mobilization of the major health authorities internationally resulted in one of the largest-scale immunization drives in modern hi…

Mindfulness-based interventions have been receiving growing attention in cancer care. This study was performed to determine the effect of a mindfulness-based stress reduction program on depression and quality of life in cancer patients. The screenings in the study were performed in January to May 2023 through the Cochr…

Patients with advanced cancer frequently have a wide range of mental and physical symptoms, making it difficult for them to communicate and make informed decisions. Necessitating the incorporation of palliative care in this population to meet their supportive care requirements.To investigate the effects of integrating…

Evidence for reducing cardiovascular and renal events with sotagliflozin is uncertain among type 2 diabetes mellitus (T2DM) patients. To gather more evidence, this meta-analysis assesses the beneficial effects of sotagliflozin, a dual sodium-glucose cotransporter 1 and 2 inhibitor, in reducing the cardiovascular and re…

OBJECTIVE: To critically appraise and assess the currently observed evidence about the difference in orthodontic treatment duration between clear aligners and fixed appliances in crowding cases. MATERIALS AND METHODS: An electronic search without limitations was conducted from inception to June 2023 covering nine data…

BACKGROUND: Staff in residential long-term care (RLTC) experience significant physical and mental work demands. However, research on specific interventions to promote staff health and well-being in RLTC facilities is limited. This systematic review aimed to synthesize the current evidence on health promotion interventi…

: Respectful maternity care promotes practices that acknowledge women's preferences and women and newborns' needs. It is an individual-centered strategy founded on ethical and human rights principles. The objective of this systematic review is to identify the impact of income on maternal care and respectful maternity c…

BACKGROUND AND PURPOSE: To determine the effects of resistance training (RT) on symptoms, function, and lower limb muscle strength in patients with knee osteoarthritis (KOA), and to determine the optimal dose-response relationships. DATA SOURCES: We searched the PubMed, MEDLINE, Embase, Cochrane Central Register of Co…

Vertical bone augmentation procedures are increasingly necessary in daily practice. However, it has been reported that vertical ridge augmentation is one of the least predictable techniques in terms of complications. The aim of this systematic review was to evaluate and compare complications in relation to the differen…

BACKGROUND AND OBJECTIVE: A highly nuanced relationship exists between obesity and lung cancer. The association between obesity and lung cancer risk/prognosis varies depending on age, gender, race, and the metric used to quantify adiposity. Increased body mass index (BMI) is counterintuitively associated with decreased…

BACKGROUND: Endotracheal intubation in neonates is challenging and requires a high level of precision, due to narrow and short airways, especially in preterm newborns. The current gold standard for endotracheal tube (ETT) verification is chest X-ray (CXR); however, this method presents some limitations, such as ionizin…