392,304 papers found

In a meta-analysis of clinical trials, an important issue is whether the treatment benefit varies according to the underlying risk of the patients in the different trials. The usual naive analyses employed to investigate this question use either the observed risk of events in the control groups, or the average risk in…

Neonatal jaundice is one of the most common problems leading to prolonged hospitalization of the newborn. Therefore, an effective low-risk, low-cost therapy reducing hospitalization is highly desirable. Plain dried agar, an extract of seaweed, is low cost and low risk; it can bind bilirubin in the gut, decreasing its e…

Tobacco and alcohol use among adolescents continue at historically high rates, and school-based interventions designed to deter students from smoking and drinking are increasingly being implemented. This study reports a meta-analysis of 47 smoking and 29 alcohol school-based intervention programs published after 1970.…

The exponential growth of secondary literature has created an imperative for researchers to identify credible and methodologically sound studies within an increasingly complex information landscape. In light of the growing emphasis on evidence-based medicine in both domestic and international contexts, umbrella reviews…

Often both aggregate data (AD) studies and individual participant data (IPD) studies are available for specific treatments. Combining these two sources of data could improve the overall meta-analytic estimates of treatment effects. Moreover, often for some studies with AD, the associated IPD maybe available, albeit at…

To extend use of the recently described 'likelihood to be diagnosed or misdiagnosed' (LDM) metric for test accuracy studies through application to recent meta-analytic data of commonly used cognitive screening instruments.Raw data (true positives and negatives, false positives and negatives) were extracted from meta-an…

Although many researchers have discussed replication as a means to facilitate self-correcting science, in this article, we identify meta-analyses and evaluating the validity of correlational and causal inferences as additional processes crucial to self-correction. We argue that researchers have a duty to describe sampl…

In this commentary, we add to the spirit of the articles appearing in the special series devoted to meta- and statistical analysis of single-case intervention-design data. Following a brief discussion of historical factors leading to our initial involvement in statistical analysis of such data, we discuss: (a) the valu…

OBJECTIVE: Published meta-analytic results should be reproducible from information available to readers. We assessed the numerical reproducibility of pairwise meta-analytic estimates of acupuncture for irritable bowel syndrome (IBS). METHODS: We searched six English- and Chinese-language databases. Eligible systematic…

BACKGROUND: Evidence synthesis refers to structured literature reviews that follow established guidelines and are reproducible, such as systematic reviews, scoping reviews, and meta-analyses. The methodological expectations for evidence synthesis, and especially systematic reviews, have evolved and become more rigorous…

The systematic review by Mevissen et al. (2025, Environment International) evaluated the evidence on the carcinogenicity of radiofrequency electromagnetic fields (RF-EMF) in laboratory animals and concluded with a high certainty of evidence (CoE) that exposure to RF-EMF increases the risk of malignant glioma and malign…

Growing evidence has suggested that probiotic consumption can decrease the incidence of Atopic dermatitis (AD) in infants and children. However, even meta-analyses have reported uncertain findings. The current umbrella meta-analysis aimed to assess the findings of multiple meta-analyses on the efficacy of probiotic sup…