376,015 papers found

To determine if chemotherapy dose intensity (DI) influences treatment outcome, 60 published studies in limited- and extensive-stage small-cell carcinoma of the lung (SCCL) were retrospectively analyzed for relationship between intended DI and response (complete response [CR] or partial response [PR]) or median survival…

We examined the effects of past use of oral contraceptives on risks of cardiovascular diseases prospectively in the Nurses' Health Study cohort. The 119,061 participants were 30 to 55 years old and free of coronary disease or stroke in 1976. They provided information on biennial questionnaires and were followed for 8 y…

The aim of coordinate-based meta-analysis is to provide valid quantitative summaries of the literature, while taking into account the specificities of neuroimaging data. Neuroimaging findings are usually reported as coordinates of effects surviving multiple comparison correction through statistical thresholding. Differ…

PURPOSE: Laparoscopic varicocelectomy has gained popularity in recent years. The aim of this study was to identify clinical evidence about the reliability of this technique in the recent literature. METHODS: We performed a Medline search for articles published during the last 10 years, using the key words "varicocele,…

BACKGROUND: Inguinal nodes dissection is associated with high rates of morbidity, lymphedema in particular is a chronic disabling condition which is a common complication following this operation. Prevention or minimization of this condition is an important aim when considering this procedure. Many technical modificati…

Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density for adult patients with cystic fibrosis. Fracture complications were also described. The objective of this study was to determine the prevalence of osteoporosis, osteopenia, and fractures among adult patients with cysti…

The influence of body composition, resting metabolic rate (RMR), and sex on variation in total energy expenditure (TEE) was examined by using meta-analysis (13 published studies in a total of 162 adults). TEE (10.9 +/- 3.2 MJ/d) was significantly correlated with body mass (BM; weighted mean converted r = 0.68, P < 0.05…

To appraise the effectiveness of the pneumonia case-management strategy in improving child survival, we have done a meta-analysis of six published intervention trials. The results of a seventh published study and two unpublished studies were also reviewed. The six published studies satisfied our criteria for methodolog…

Low-molecular-weight heparins (LMWHs) have theoretical advantages over standard heparin as postoperative thromboprophylactic agents. We conducted a meta-analysis of studies reported between 1984 and April, 1991, in which LMWHs were compared with standard heparin for postoperative prophylaxis. We included only randomise…

OBJECTIVE: To quantitatively assess the efficacy and safety of published randomized trials comparing subcutaneous heparin with continuous intravenous heparin for the initial treatment of deep vein thrombosis. DATA IDENTIFICATION: Studies published between January 1986 and April 1991 were identified through computer se…

A statistical overview of published results on correlations between various prognostic factors in breast cancer was undertaken. A distinction was made between clinical (or anatomical) prognostic factors--namely, axillary lymph node status and tumour size--and eight different biological prognostic factors. The latter in…

Controversy about gastric cancer risk after partial gastrectomy exists, especially in the United States. Therefore, we performed a meta-analysis to determine overall relative risk and weighted mean relative risk for subsets of postgastrectomy patients, define possible high risk patients suitable for surveillance, and a…

BACKGROUND AND AIM: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver condition and a major cause of cirrhosis, hepatocellular carcinoma, and liver transplantation. Resmetirom, a thyroid hormone receptor &#x3b2; agonist, and Efruxifermin, a fibroblast growth factor 21 analogue, have shown p…

BACKGROUND: Children with ADHD frequently face social dysfunction hindering neurodevelopment. While exercise shows promise, the relative efficacy of specific modalities and precise dose-response relationships remain undefined. This study compares exercise modalities to identify the optimal dose for enhancing social fun…

Lofepramine is a tricyclic antidepressant related to imipramine. Meta-analyses were carried out with respect to efficacy and tolerability by combining outcome and adverse reaction from over 20 controlled trials comparing lofepramine with other tricyclic antidepressants. Lofepramine was at least as effective as the comp…

BACKGROUND: With almost a million people dying by suicide worldwide each year, reducing the rate of suicidal behaviour is a priority in many countries. AIMS: To examine whether additional psychosocial interventions following an episode of self-harm reduce the likelihood of subsequent suicide. METHOD: We conducted a s…

Photoparoxysmal responses (PPRs) are generalized epileptiform abnormalities occurring during photic stimulation. Prolonged PPRs, which outlast the stimulus, can be distinguished from self-limited PPRs, which cease spontaneously or when the flashes stop. Reilly and Peters (1973) found a higher incidence of seizures in p…

We conducted a meta-analytic study to measure the risk of uterine cervical cancer in former and current smokers. A literature search from 1966 to 1988 identified 139 MEDLINE citations. Of these, five studies reported appropriate and complete data for meta-analysis. A recent study conducted by the authors was also inclu…