376,015 papers found

Photoparoxysmal responses (PPRs) are generalized epileptiform abnormalities occurring during photic stimulation. Prolonged PPRs, which outlast the stimulus, can be distinguished from self-limited PPRs, which cease spontaneously or when the flashes stop. Reilly and Peters (1973) found a higher incidence of seizures in p…

We conducted a meta-analytic study to measure the risk of uterine cervical cancer in former and current smokers. A literature search from 1966 to 1988 identified 139 MEDLINE citations. Of these, five studies reported appropriate and complete data for meta-analysis. A recent study conducted by the authors was also inclu…

UNLABELLED: While previous meta-analyses have established a link between vitamin A supplementation and outcomes in children with pneumonia, the efficacy and safety of different dosing regimens remain unclear. Existing evidence is predominantly based on single-dose trials, creating a critical knowledge gap. We systemati…

OBJECTIVE: The present Bayesian network meta-analysis (NMA) aims to evaluate and compare the efficacy of aerobic training (AT), resistance training (RT), high-intensity interval training (HIIT), and combined training (CT) on biomarkers of chronic low-grade systemic inflammation (CLGSI) in postmenopausal women with over…

BACKGROUND: Pregnancy-related mental health disorders are an increasingly important global public health concern. Exercise interventions have gained attention as safe, non-pharmacological strategies for improving maternal psychological and neurophysiological well-being. However, comparative evidence regarding different…

Nausea and vomiting in pregnancy affects up to 80% of pregnant women and may progress to hyperemesis gravidarum, leading to maternal morbidity and adverse pregnancy outcomes. Despite numerous pharmacological and non-pharmacological options, the comparative efficacy and safety of these interventions remain unclear.We co…

BACKGROUND: Auriculotherapy has been used extensively for insomnia in traditional Chinese medicine due to its high effectiveness and few adverse effects. However, there are several auriculotherapy approaches, and it's still uncertain which is best for treating primary insomnia (PI). The purpose of this study is to dete…

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely linked to obesity and insulin resistance, and sustained weight loss is associated with histological improvement. Whether different obesity-management modalities exert weight-independent hepatic effects remains uncertain. METHODS: W…

BACKGROUND AND AIMS: Exercise is key to ameliorating sleep disorders in obese populations; however, the relative benefits of different exercise modes and the optimal dosage remain unclear. This study aims to systematically evaluate the relative efficacy and dose-response characteristics of seven exercise interventions…

BACKGROUND: Nutritional supplementation is increasingly regarded as a potential strategy to preserve or enhance cognitive function in individuals with healthy aging and mild cognitive impairment (MCI). However, its overall efficacy remains uncertain due to inconsistent findings across clinical trials. METHODS: In acco…

BACKGROUND: The global prevalence of type 2 diabetes mellitus (T2DM) is rising, significantly increasing the risk of cognitive impairment and dementia. Although exercise improves cognitive function in T2DM, few studies have compared different exercise modalities. This network meta-analysis assessed their effects on glo…

INTRODUCTION: The promise of faster, simpler restorations has driven the rise of bulk-fill composites, but do speed and simplicity come at the cost of longevity and marginal integrity? OBJECTIVE: To compare and rank the clinical performance of bulk-fill and conventional incremental layering restoration techniques in C…

OBJECTIVES: To compare the effectiveness of various endotracheal tube (ETT) cuff materials, shapes, and antimicrobial coatings in preventing ventilator-associated pneumonia (VAP) through a network meta-analysis. METHODS: Six databases were searched up to February 2025 for relevant randomized controlled trials (RCTs).…

PURPOSE: To systematically evaluate and compare the efficacy and safety profiles of various immunomodulatory therapies for Behçet's Disease-associated uveitis (BDU) through network meta-analysis, providing evidence-based guidance for clinical practice. METHODS: We conducted a comprehensive systematic review follo…

BACKGROUND: Dysfunction of the autonomic nervous system (characterized by excessive sympathetic activation and reduced parasympathetic activity) is regarded as 1 of the primary mechanisms of heart failure. Theoretically, nerve stimulation or modulation targeting this autonomic imbalance could improve outcomes in heart…

OBJECTIVES: Few head-to-head comparisons of cocaine dependence medications exist, and combining data from different randomized controlled trials (RCTs) is fraught with methodological challenges including limited generalizability of the RCT findings. This study applied a novel meta-analytic approach to data of cocaine d…

This study reviews the available evidence on the efficacy of antibiotic prophylaxis in cesarean sections. The study included a detailed analysis of the quality of design and performance and the clinical heterogeneity of selected clinical trials. Meta-analysis of placebo-controlled trials estimated an efficacy of some 6…

Since the first report of an association between asymptomatic bacteriuria and low birth weight (less than 2,500 g) in 1962, greater than 30 other studies on the same subject have been published. Some of these confirmed this association while others disputed it. Now, however, by using meta-analysis (a technique consider…

The literature concerning mortality after a diagnosis of choroidal melanoma was reviewed to identify relevant articles published from 1966 through 1988 and to select those with mortality rates presented separately by tumor size for inclusion in a pooled analysis (meta-analysis) of 5-year mortality after enucleation for…

BACKGROUND: This paper is the first of two reports that together review the scientific evidence regarding the inverse relation between physical activity and cardiovascular fitness and coronary heart disease (CHD). METHODS: In Part I, the evidence suggesting a causal link between physical activity and CHD protection in…