11,356,787 papers found

A potent growth inhibitor for normal mammary epithelial cells is transforming growth factor beta 1 (TGF-β1). When breast tissues lose the anti-proliferative activity of this factor, invasion and bone metastases increase. Human breast cancer (hBC) cells express more activating transcription factor 3 (ATF3) when ex…

Anthrax is more prevalent in impoverished nations and those without veterinarian public health initiatives. A comprehensive strategy was pursued to build an anthrax-free model in which there would be no anthrax. The strategy included routine vaccination, increased public awareness, rapid confirmation, and prompt dispos…

OBJECTIVES/BACKGROUND: This study was undertaken to assess the prevalence of primary stabbing headache (PSH) among adult patients seeking medical attention for headache in a clinic-based setting. PSH is a primary headache disorder and is one of the representatives of indomethacin-responsive cephalalgias. The epidemiolo…

OBJECTIVE: To study the demographic and clinical features of infantile hemangioma in Uzbekistan; to learn in more detail the risk factors for developing this disease; and to identify clinical characteristics associated with complications, associated risks, and the need for systemic treatment. MATERIAL AND METHODS: A c…

BACKGROUND: Ungraded extracapsular spread (ECS) has been found non-prognostic in p16-positive, surgically-treated oropharynx squamous cell carcinoma (OPSCC). However, soft tissue metastasis (STM), the highest ECS grade, is reported prognostic. Our study's objective is to explore STM relative to distant metastasis (DM),…

This study's objective is to understand distally-referred surface electrical nerve stimulation (DR-SENS) and evaluates the effects of electrode placement, polarity, and stimulation intensity on the location of elicited sensations in non-disabled individuals.A two-phased human experiment was used to characterize DR-SENS…

BACKGROUND: The complex configuration of the thumb carpometacarpal (CMC-1) joint relies on musculotendinous and ligamentous support for precise circumduction. Ligament innervation contributes to joint stability and proprioception. Evidence suggests abnormal ligament innervation is associated with osteoarthritis (OA) in…

Lithium, a therapeutic agent for bipolar disorder, can induce G2/M arrest in various cells, but the mechanism is unclear. In this article, we demonstrated that lithium arrested hepatocellular carcinoma cell SMMC-7721 at G2/M checkpoint by inducing the phosphorylation of cdc2 (Tyr-15). This effect was p53 independent an…

This study examined the presence and strengths of determinants associated with consultation of an in-house expert on child abuse and neglect (CAN) by preventive child health care professionals who suspect CAN. This study also assessed the relationship between in-house CAN expert consultation and professionals' performa…

BACKGROUND: Intracytoplasmic sperm injection (ICSI) has revolutionized the treatment of couples with male factor infertility but results remain suboptimal and suggest the need for further investigation into the molecular biology of spermatozoa. Vitamin D has been implicated in spermatogenesis and sperm function. Hypovi…

The amount of solid waste generated in developing countries is rising over time due to economic growth, change inconsumer behavior, and lifestyles of people. But it is hard to manage and handle the increase of solid waste with existing waste management infrastructure. Thus, the management system of solid waste is very…

Despite their important role in security, little is known about the energy requirements of working dogs such as odor, explosive and human detection dogs. Previous researchers have evaluated the energy requirements of individual canine breeds as well as dogs in exercise roles such as sprint racing. This study is the fir…

Pancreatic ductal adenocarcinoma (PDAC) is recognized for its aggressive nature, dismal prognosis, and a notably low five-year survival rate, underscoring the critical need for early detection methods and more effective therapeutic approaches. This research rigorously investigates the molecular mechanisms underlying PD…

AIM: To systematically explore the existing literature by examining nursing approaches to home chemotherapy treatment. BACKGROUND: With the rising number of patients with cancer, home chemotherapy has gained prominence. Nurses play a crucial role in this process and bear significant responsibilities. INTRODUCTION: Ho…

Hookah (water pipe) smoking, an old method of tobacco smoking, is regaining widespread popularity all over the world. Although the research in this field is still deficient, it has been proven for its harmful effect on human's health by increasing the risk of cardiovascular disease, infection and lung, oral and bladder…

AIM: Complex regional pain syndrome type I (CRPS-I) is a specific type of persistent pain which is often caused by fracture and surgery. There is no effective curative therapy available. However some studies have indicated that Vitamin C (VC) can reduce the incidence of CRPS-I. This study's objective is to investigate…

It has been reported that patients undergoing orthodontic treatment present a high risk of caries. Recently, an immediate chair-side test was proposed, displaying the intra-oral lactic acid production of cariogenic bacteria. The aim of this 12-month follow-up prospective cohort study was to evaluate the association bet…

Fibrocytes are bone marrow hematopoietic-derived cells that also express a mesenchymal cell marker (commonly collagen I) and participate in fibrotic diseases of multiple organs. Given their origin, they or their precursors must be circulating cells before recruitment into target tissues. While most previous studies foc…

AIMS: This article reports the study of a group of United Kingdom health visitors' interactions with their changing practice context, focusing on role identity and influences on its stability. BACKGROUND: United Kingdom policies have urged health visitors to refocus their role as key public health nurses. Reduced role…