97,465 papers found

To summarize the long-term efficacy of nicotinamide in treating pediatric early-onset progressive encephalopathy with brain edema and (or) leukoencephalopathy-2 (PEBEL2) caused by NAXD gene variationThis was a case report conducted from February 2019 to January 2025. The long-term efficacy of nicotinamide was observed…

OBJECTIVE: Spinal pathologies are prevalent in Nigeria, though epidemiological data remains sparse. This systematic review used pooled patient-level data from across the country to generate a standardized epidemiological reference. METHODS: Four research databases and gray literature sources were searched. Risk of bia…

BACKGROUND: Previous studies reported decreased volumes of acute stroke admissions during the COVID-19 pandemic. We aimed to examine whether aneurysmal subarachnoid hemorrhage (aSAH) volumes demonstrated similar declines in our department. Furthermore, the impact of the pandemic on disease progression should be analyze…

The risk stratification and early interventions are necessary in patients with hypertrophic cardiomyopathy (HCM), as life-threatening arrhythmia (LTA) is a leading cause of death. This study aimed to explore whether an interval between the peak of the T wave to the end terminal of the T wave (Tp-e), which represents ve…

This study aimed at analysing the causes and predictors of acute hospitalization and mortality in a cohort of SSc. Retrospective analysis of all acute hospital admissions of SSc patients fulfilling the 2013 EULAR/ACR Classification Criteria, from a single-centre cohort of 95 patients, between 2010 and 2020. The total n…

OBJECTIVE: To investigate the effectiveness of anterolateral femoral flap in combination with fascia lata grafting in repair of large Achilles tendon and skin defects. METHODS: The clinical data of 18 patients with large Achilles tendon and skin defects repaired with anterolateral femoral flap in combination with fasc…

PURPOSE: We sought to determine long-term outcomes after deferred radical prostatectomy. MATERIALS AND METHODS: The study population consisted of all 132 men with screening detected prostate cancer who underwent deferred radical prostatectomy from January 1, 1995 to December 31, 2014 after active surveillance in the G…

BACKGROUND: To examine the results of myectomy and mitral valve surgery for systolic anterior motion (SAM) of the mitral valve and left ventricular outflow tract obstruction (LVOTO) with a relatively thin interventricular septum. METHODS: The subjects were 12 patients with SAM and LVOTO. Eight had hypertrophic obstruc…

PURPOSE: To report our clinical experience and 12-month results of small-incision Descemet-stripping endothelial keratoplasty (DSEK). METHODS: Prospective study of 11 eyes of 9 patients who had DSEK. The DSEK technique consisted of stripping the Descemet membrane and endothelium from the recipient cornea. The donor bu…

PURPOSE: This study was designed to evaluate pregnancy, delivery, and functional outcome in females before and after ileal pouch-anal anastomosis for chronic ulcerative colitis. METHODS: From a prospective database of 1,454 patients who underwent ileal pouch-anal anastomosis for chronic ulcerative colitis between 1981…

One hundred and sixty-eight years lie between the first description of mitochondria as "pale roundish granules" and their eventual recognition as the "chief executive organelle" of the cell. Booming mitochondrial research during the last three decades has revealed that being the "powerhouse of the cell" is just one of…

Over the last ten years, zoos and aquariums around the world have been coming to grips with the "sustainability crisis" - the realization that most of our collaboratively managed animal populations are not viable for the long-term. Many initiatives have been launched at the regional, zoological association, program, an…

Wuchereria bancrofti and Mansonella ozzardi are both endemic in Haiti. Over the last hundred years, these human parasites have been by turn investigated and disregarded. Between 1894 and 1914, Haitian physicians encouraged by Dr. Léon AUDAIN studied the clinical and biological impact of W. bancrofti in the numerou…

For the last years we have witnessed and increasing awareness of the part of doctors and teachers who by means of the education for the health (EpS) promote the acquisition of healthy habits among students at schools. One of those educational contents is the smoking prevention. The participation of pneumologists in tho…

Continent urinary diversion has become increasingly popular in the last few years and there are now several situations in which ileal conduit diversion, continent diversion and orthotopic reconstruction of the lower urinary tract are equally valid options. This review was intended to determine specific indications for…

Background Anterior cervical discectomy and fusion (ACDF) is a common surgical procedure that patients undergo for cervical disc herniations and degenerative disc disease, aimed at relieving radicular symptoms and restoring cervical alignment. The impact of preoperative kyphotic cervical imbalance versus preoperative l…

Approximately one in four patients experiences nausea and/or vomiting in anticipation of a chemotherapy treatment by the time of their fourth treatment cycle. Anticipatory nausea and vomiting is a prevalent problem of clinical significance in the total management of chemotherapy side effects. While refractory to standa…

IntroductionReal-world behavioural interventions are required that support long-term weight loss maintenance. This study evaluates the most recent weight and body mass index (BMI) outcomes of adults who first joined a community weight management programme in 2016 and accessed support >two years later.MethodsElectronic…

BACKGROUD: Osteoporotic vertebral compression fractures (OVCF) cascades (OVCFcs) repeatedly cause vertebral compression to involve multiple vertebra. This study aimed to introduce an accelerated form of OVCFcs: acute multiple OVCF (amOVCF). METHODS: OVCF patients with multiple vertebral augmentations in a spine center…

BACKGROUND: Childhood cancers are known to cause significant morbidity and mortality, and the incidence has been increasing exponentially in developing countries. Two studies performed in Namibia in 1988 and 2010 have shown changes in the pattern of paediatric cancers over the years. There is a constant need to have up…