44,688 papers found

BACKGROUND: A number of observational studies have found an association between low vitamin D levels and risk of sepsis. We conducted a systematic review and meta-analysis to determine the overall estimate of risk. METHODS: This was a systematic review and meta-analysis conducted by online searches (CENTRAL, PubMed/ME…

BACKGROUND: The utility of acupuncture in managing osteoarthritis symptoms is uncertain. Trial results are conflicting and previous systematic reviews may have overestimated the benefits of acupuncture. METHODS: Two reviewers independently identified randomized controlled trials (up to May 2014) from multiple electron…

Age-related macular degeneration (AMD) is the leading cause of permanent, irreversible, central blindness (scotoma in the central visual field that makes reading and writing impossible, stereoscopic vision, recognition of colors and details) in patients over the age of 50 years in European and North America countries,…

OBJECTIVE: Evaluate content and educational delivery methods of preoperative education in total joint arthroplasties of the hip and knee (THA and TKA) addressing postoperative pain. DATA SOURCES: Systematic searches conducted on Biomed Central, BMJ.com, CINAHL, the Cochrane Library, NLM Central Gateway, OVID, ProQuest…

AIMS: To examine the literature pertaining to the diversion and misuse of pharmaceutical stimulants. METHODS: Relevant literature was identified through comprehensive MEDLINE, EMBASE and PubMed searches. RESULTS: The evidence to date suggests that the prevalence of diversion and misuse of pharmaceutical stimulants va…

BACKGROUND: The local and systemic humoral response after colorectal surgery is thought to affect postoperative recovery. It is commonly claimed that laparoscopic surgery elicits a diminished inflammatory response than equivalent open surgery. Despite these claims, the evidence is conflicting. Therefore, we aimed to sy…

BACKGROUND: Systematic review and meta-analysis to evaluate the effect of bevacizumab (Avastin) in diabetic macular edema (DME) METHODS: Pertinent publications were identified through systematic searches of PUBMED and Cochrane Central Register of Controlled Trials. Change in central subfield macular thickness (CSMT) in…

OBJECTIVES: To review the findings of structural and functional neuroimaging studies in attention-deficit hyperactivity disorder (ADHD), with a focus on abnormalities reported in brain regions that lie outside the frontostriatal circuitry, which is currently believed to play a central role in the pathophysiology of ADH…

BACKGROUND: Autism is a severe neurodevelopmental disorder known to have many different etiologies. In the last few years, significant progresses have been made in comprehending the causes of autism and their multiple impacts on the developing brain. This article aims to review the current understanding of the etiologi…

OBJECTIVE: The use of wearable motion-sensing technology offers important advantages over conventional methods for obtaining measures of physical activity and/or physical functioning in aged individuals. This review aims to identify the actual state of applying wearable systems for monitoring mobility-related activity…

PURPOSE: To describe adult attention-deficit/hyperactivity disorder (ADHD) in relation to gender-based differences in symptom expression with particular emphasis on disparities concerning women, psychiatric comorbidities that affect assessment and detection, and evidenced-based treatment approaches for nurse practition…

Interest in glucagon-like peptide-1 receptor agonists (GLP-1RAs) has expanded beyond obesity and diabetes, with growing preclinical and clinical evidence supporting potential applications in psychiatric and neurodegenerative disorders. However, the central nervous system (CNS) mechanisms engaged by GLP-1RAs remain poor…

CONTEXT: Letrozole, a third-generation aromatase inhibitor, has been increasingly investigated as an off-label treatment to improve growth outcomes in paediatric boys, whereas its use in girls has remained limited because of concerns regarding safety and efficacy, given the critical role of oestrogens in female physiol…

The main characteristic of point-of-care testing (PoCT) is to provide rapid test results. It remains uncertain whether faster PoCT results truly improve patient management in the emergency department (ED), and how robust the supporting evidence is. This systematic review aimed to summarize the impact of PoCT in ED on t…

OBJECTIVE: This review will map the use of the Fundamentals of Care (FoC) Framework in health care. INTRODUCTION: Health care systems are increasingly complex, but person-centered care remains central to nursing, and the FoC Framework provides a structured approach to embedding this principle in practice. It emphasize…

OBJECTIVE: To evaluate the predictive value of the R.E.N.A.L., PADUA, and (MC)scoring systems for complications after renal tumor ablation. METHOD: This systematic review and meta-analysis was reported in accordance with PRISMA and registered in PROSPERO. PubMed, Embase, the Cochrane Library, and Web of Science were s…

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a major subtype of secondary HLH and is increasingly recognized as a heterogeneous entity. However, the clinical differences between acute EBV-HLH (AEBV-HLH) and chronic active EBV infection-associated HLH (CAEBV-HLH) have not been systematic…

BACKGROUND: Exercise-induced leg pain is a common and often disabling complaint in young and physically active individuals. Chronic exertional compartment syndrome (CECS) remains one of the most debated diagnoses within this spectrum due to persistent uncertainty regarding its pathophysiology, diagnostic criteria, and…

BACKGROUND: Total hip arthroplasty (THA) is the optimal surgical procedure for treating end-stage hip diseases. However, ipsilateral knee pain after THA, as a relatively insidious and not yet fully recognized complication, affects patient satisfaction and functional recovery. Its etiology is complex, involving the inte…

BACKGROUND: Silicosis is a progressive fibrotic lung disease caused by chronic inhalation of crystalline silica. Increasing evidence indicates that oxidative stress plays a central role in linking silica exposure to inflammation, tissue injury, and fibrosis. We conducted a systematic review to critically appraise the c…